We are analyzing https://link.springer.com/article/10.1007/s10495-010-0503-y.

Title:
Phosphatidylserine targeting for diagnosis and treatment of human diseases | Apoptosis
Description:
Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the plasma membrane. These features have made PS-externalization a well-explored phenomenon to image cell death for diagnostic purposes. In addition, it was demonstrated that under certain conditions viable cells express PS at their surface such as endothelial cells of tumor blood vessels, stressed tumor cells and hypoxic cardiomyocytes. Hence, PS has become a potential target for therapeutic strategies aiming at Targeted Drug Delivery. In this review we highlight the biomarker PS and various PS-binding compounds that have been employed to target PS for diagnostic purposes. We emphasize the 35 kD human protein annexin A5, that has been developed as a Molecular Imaging agent to measure cell death in vitro, and non-invasively in vivo in animal models and in patients with cardiovascular diseases and cancer. Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their surface.
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Keywords {🔍}

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Topics {✒️}

low-density-lipoprotein receptor-deficient mice vitamin k-dependent proteins ca2+-dependent phospholipid-binding protein unilateral mca occlusion/reperfusion annexin a5-functionalized liposomes soluble tissue factor-annexin focal hypoxic-ischemic injury annexin super-gene family article download pdf porcine ischemia-reperfusion model radiation-enhanced vascular targeting 99mtc-recombinant human annexin ca2+-binding sites protrude ca2+/phospholipid-binding fold anti-fas ligand antibody ca2+-ions bind imaging beta-cell death whilst scott b-cells 99mtc-hynic-rh-annexin universal ca2+-binding domain anti-idiotypic monoclonal antibody cell surface-expressed phosphatidylserine image cell death 99mtc-labeled annexin a5 targeted contrast agent blood-brain barrier permeability lovo tumour-bearing mice membrane-binding protein annexin phosphatidylserine-specific binding sites targeting phosphatidylserine-exposing membranes minimal detrimental side-effects related subjects ultrasmall protein-coupled probes lipid transfer protein target-specific molecular probe early treatment-induced apoptosis site-directed chemical linkage targeted drug delivery annexin a5 open c2a-gst depicts feasibility article schutters privacy choices/manage cookies programmed cell loss calcium-independent membrane binding kristof schutters 99mtc-labeled c2a domain full access specific biochemical reactions complex structure/function relationship fusion protein c2a-gst

Schema {🗺️}

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         headline:Phosphatidylserine targeting for diagnosis and treatment of human diseases
         description:Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the plasma membrane. These features have made PS-externalization a well-explored phenomenon to image cell death for diagnostic purposes. In addition, it was demonstrated that under certain conditions viable cells express PS at their surface such as endothelial cells of tumor blood vessels, stressed tumor cells and hypoxic cardiomyocytes. Hence, PS has become a potential target for therapeutic strategies aiming at Targeted Drug Delivery. In this review we highlight the biomarker PS and various PS-binding compounds that have been employed to target PS for diagnostic purposes. We emphasize the 35 kD human protein annexin A5, that has been developed as a Molecular Imaging agent to measure cell death in vitro, and non-invasively in vivo in animal models and in patients with cardiovascular diseases and cancer. Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their surface.
         datePublished:2010-05-04T00:00:00Z
         dateModified:2010-05-04T00:00:00Z
         pageStart:1072
         pageEnd:1082
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         keywords:
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            Phosphatidylserine
            Annexin A5
            Molecular Imaging
            Targeted Drug Delivery
            Cancer Research
            Cell Biology
            Oncology
            Biochemistry
            general
            Virology
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ScholarlyArticle:
      headline:Phosphatidylserine targeting for diagnosis and treatment of human diseases
      description:Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the plasma membrane. These features have made PS-externalization a well-explored phenomenon to image cell death for diagnostic purposes. In addition, it was demonstrated that under certain conditions viable cells express PS at their surface such as endothelial cells of tumor blood vessels, stressed tumor cells and hypoxic cardiomyocytes. Hence, PS has become a potential target for therapeutic strategies aiming at Targeted Drug Delivery. In this review we highlight the biomarker PS and various PS-binding compounds that have been employed to target PS for diagnostic purposes. We emphasize the 35 kD human protein annexin A5, that has been developed as a Molecular Imaging agent to measure cell death in vitro, and non-invasively in vivo in animal models and in patients with cardiovascular diseases and cancer. Recently focus has shifted from diagnostic towards therapeutic applications employing annexin A5 in strategies to deliver drugs to cells that express PS at their surface.
      datePublished:2010-05-04T00:00:00Z
      dateModified:2010-05-04T00:00:00Z
      pageStart:1072
      pageEnd:1082
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s10495-010-0503-y
      keywords:
         Apoptosis
         Phosphatidylserine
         Annexin A5
         Molecular Imaging
         Targeted Drug Delivery
         Cancer Research
         Cell Biology
         Oncology
         Biochemistry
         general
         Virology
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-010-0503-y/MediaObjects/10495_2010_503_Fig3_HTML.gif
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                     type:PostalAddress
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            affiliation:
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      name:Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands

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