We are analyzing https://link.springer.com/article/10.1007/s10495-009-0315-0.

Title:
NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy | Apoptosis
Description:
It has become increasingly clear that deregulation of the NFκB signaling cascade is a common underlying feature of many human ailments including cancers. The past two decades of intensive research on NFκB has identified the basic mechanisms that govern the functioning of this pathway but uncovering the details of why this pathway works differently in different cellular contexts or how it interacts with other signaling pathways remains a challenge. A thorough understanding of these processes is needed to design better and more efficient therapeutic approaches to treat complex diseases like cancer. In this review, we summarize the literature documenting the involvement of NFκB in cancer, and then focus on the approaches that are being undertaken to develop NFκB inhibitors towards treatment of human cancers.
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Keywords {🔍}

google, scholar, pubmed, cas, article, cancer, nfkappab, cell, cells, apoptosis, human, nuclear, activation, death, biol, mol, inhibition, res, signaling, factorkappab, kinase, tumor, therapy, tergaonkar, pathway, skin, autophagy, inhibitor, shen, rev, necrosis, ther, molecular, oncogene, proteasome, role, factor, activity, karin, immunol, nature, clin, reactive, oxygen, potential, target, inflammation, regulation, tcell, nfκb,

Topics {✒️}

c-jun n-terminal kinase htlv-i-infected t-cell lines adult t-cell leukemia/lymphoma nuclear factor-kappab-regulated antiapoptotic tnfalpha-induced nf-kappab activation adult t-cell leukemia receptor-interacting protein nf-kappab inhibitor dehydroxymethyl-epoxyquinomicin nf-kappab signalling cascade integrating cell-signalling pathways month download article/chapter death receptor-induced apoptotic uv-mediated nf-kappab activation mtor/s6k1 signalling pathway death receptor-mediated apoptosis autophagy-mediated proteasome-independent degradation cytokine-driven compensatory proliferation tnf-alpha-induced apoptosis nuclear factor-kappab inhibitors suppressing nuclear factor-kappab constitutively active nf-kappab induce tnfalpha-dependent apoptosis nuclear factor-kappab activation starvation-induced cell death tumor necrosis factor nf-kappab-inducing kinase nf-kappab-induced junb transcription factor nf-kappab han-ming shen nuclear factor-kappab inhibition enhances anti-tumor activity akt serine-threonine kinase serine/threonine kinase akt reactive oxygen species high-risk myelodysplastic syndrome smac-mimetic-induced apoptosis nf-kappab signaling module caspase-independent cell death uvb-induced skin cancer inhibits nf-kappab activation nf-kappab inhibition sensitizes hepatocyte necrosis induced functional nf-kappab activity sequential dna damage-independent ikk/nf-kappab signaling nf-kappab-mediated control r-roscovitine simultaneously targets uvb-induced skin carcinogenesis p52 nf-kappab subunit nuclear factor-kappab

Questions {❓}

Ang HL, Tergaonkar V (2007) Notch and NFkappaB signaling pathways: do they collaborate in normal vertebrate brain development and function?
NF-κB signaling in cancer stem cells: a promising therapeutic target?
Olivier S, Robe P, Bours V (2006) Can NF-kappaB be a target for novel and efficient anti-cancer agents?
Srinivasula SM, Ashwell JD (2008) IAPs: what’s in a name?

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