We are analyzing https://link.springer.com/article/10.1007/s10495-008-0240-7.

Title:
JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins | Apoptosis
Description:
UVB irradiation induced phosphorylation of JNK and subsequent apoptosis in human melanocytes. Depletion of both JNK1 and JNK2 expression using siRNA transfection, protected against apoptosis, as detected by decreased nuclear fragmentation and caspase-3 activity, as well as reduced translocation of Bax to mitochondria. Moreover, release of cathepsin B and D from lysosomes to the cytosol was reduced when JNK expression was suppressed by siRNA, demonstrating a JNK dependent regulation of lysosomal membrane permeabilization. In unirradiated control melanocytes, coimmunoprecipitation showed that Bim was sequestered by Mcl-1, which had a pro-survival function. After UVB irradiation, a significant decrease in Mcl-1 protein level was found, which was prevented by addition of a proteasome inhibitor. The interaction between Bim and Mcl-1 was reduced in response to UVB irradiation and Bim was phosphorylated in a JNK dependent manner. In conclusion, these findings suggest JNK to have an important pro-apoptotic function following UVB irradiation in human melanocytes, by acting upstream of lysosomal membrane permeabilization and Bim phosphorylation.
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Keywords {🔍}

article, pubmed, google, scholar, apoptosis, jnk, cas, cell, biol, bcl, mcl, proteins, human, chem, lysosomal, melanocytes, bim, death, doijbcm, membrane, family, bivik, phosphorylation, proapoptotic, bhonly, privacy, cookies, content, permeabilization, irradiation, differ, pathway, function, publish, research, search, öllinger, uvb, caspase, activity, bax, cathepsin, access, doisjcdd, linköping, data, information, log, journal, mediates,

Topics {✒️}

c-jun n-terminal kinase lysosomal membrane permeabilization month download article/chapter uva/b-induced apoptosis uvb-induced apoptosis outer mitochondrial membrane important pro-apoptotic function n-acetyl-beta-glucosaminidase related subjects article apoptosis aims receptor-mediated apoptosis bim-related members swedish research council full article pdf article bivik privacy choices/manage cookies jnk dependent manner cecilia bivik pro-apoptotic activity proteins induce apoptosis induced apoptosis acting upstream bcl-2 family proteins findings suggest jnk stress-induced activation bcl-2 family members jnk dependent regulation bid-mediated caspase-9 beta-carotene uptake cultured human fibroblasts pro-survival function cathepsin protease pathways jnk phosphorylation european economic area decreased nuclear fragmentation post-translational control mouse embryonic fibroblasts dynein motor complex johnson em jr van delft mf keratinocyte rescue effects k2005-31x-15318-01a conditions privacy policy bcl-2/bax expression photo-oxidative disruption wavelength-specific effects uvb irradiation lysosomal pathway unirradiated control melanocytes accepting optional cookies

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         headline:JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins
         description:UVB irradiation induced phosphorylation of JNK and subsequent apoptosis in human melanocytes. Depletion of both JNK1 and JNK2 expression using siRNA transfection, protected against apoptosis, as detected by decreased nuclear fragmentation and caspase-3 activity, as well as reduced translocation of Bax to mitochondria. Moreover, release of cathepsin B and D from lysosomes to the cytosol was reduced when JNK expression was suppressed by siRNA, demonstrating a JNK dependent regulation of lysosomal membrane permeabilization. In unirradiated control melanocytes, coimmunoprecipitation showed that Bim was sequestered by Mcl-1, which had a pro-survival function. After UVB irradiation, a significant decrease in Mcl-1 protein level was found, which was prevented by addition of a proteasome inhibitor. The interaction between Bim and Mcl-1 was reduced in response to UVB irradiation and Bim was phosphorylated in a JNK dependent manner. In conclusion, these findings suggest JNK to have an important pro-apoptotic function following UVB irradiation in human melanocytes, by acting upstream of lysosomal membrane permeabilization and Bim phosphorylation.
         datePublished:2008-07-24T00:00:00Z
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      headline:JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins
      description:UVB irradiation induced phosphorylation of JNK and subsequent apoptosis in human melanocytes. Depletion of both JNK1 and JNK2 expression using siRNA transfection, protected against apoptosis, as detected by decreased nuclear fragmentation and caspase-3 activity, as well as reduced translocation of Bax to mitochondria. Moreover, release of cathepsin B and D from lysosomes to the cytosol was reduced when JNK expression was suppressed by siRNA, demonstrating a JNK dependent regulation of lysosomal membrane permeabilization. In unirradiated control melanocytes, coimmunoprecipitation showed that Bim was sequestered by Mcl-1, which had a pro-survival function. After UVB irradiation, a significant decrease in Mcl-1 protein level was found, which was prevented by addition of a proteasome inhibitor. The interaction between Bim and Mcl-1 was reduced in response to UVB irradiation and Bim was phosphorylated in a JNK dependent manner. In conclusion, these findings suggest JNK to have an important pro-apoptotic function following UVB irradiation in human melanocytes, by acting upstream of lysosomal membrane permeabilization and Bim phosphorylation.
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         Cancer Research
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         Virology
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