We are analyzing https://link.springer.com/article/10.1007/s10495-006-9527-8.

Title:
Clearance of apoptotic and necrotic cells and its immunological consequences | Apoptosis
Description:
The ultimate and most favorable fate of almost all dying cells is engulfment by neighboring or specialized cells. Efficient clearance of cells undergoing apoptotic death is crucial for normal tissue homeostasis and for the modulation of immune responses. Engulfment of apoptotic cells is finely regulated by a highly redundant system of receptors and bridging molecules on phagocytic cells that detect molecules specific for dying cells. Recognition of necrotic cells by phagocytes is less well understood than recognition of apoptotic cells, but an increasing number of recent studies, which are discussed here, are highlighting its importance. New observations indicate that the interaction of macrophages with dying cells initiates internalization of the apoptotic or necrotic targets, and that internalization can be preceded by “zipper”-like and macropinocytotic mechanisms, respectively. We emphasize that clearance of dying cells is an important fundamental process serving multiple functions in the regulation of normal tissue turnover and homeostasis, and is not just simple anti- or pro-inflammatory responses. Here we review recent findings on genetic pathways participating in apoptotic cell clearance, mechanisms of internalization, and molecules involved in engulfment of apoptotic versus necrotic cells, as well as their immunological consequences and relationships to disease pathogenesis.
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Keywords {🔍}

google, scholar, pubmed, cas, cells, apoptotic, cell, biol, phagocytosis, death, immunol, phosphatidylserine, macrophages, clearance, necrotic, engulfment, receptor, exp, apoptosis, med, recognition, protein, macrophage, article, elegans, activation, differ, nature, fadok, neutrophils, krysko, chem, human, factor, growth, induces, dying, phagocytes, mol, henson, tumor, vandenabeele, mechanisms, ced, binds, mice, cancer, nat, exposure, surface,

Topics {✒️}

unc-73/trio-mig-2/rhog signaling module mannose-binding lectin engagement conserved crkii/dock180/rac pathway month download article/chapter heat-shock protein receptors crkii-dock180-rac1 complex transforming growth factor-beta dna-dependent protein kinase phosphatidylserine-dependent beta2-glycoprotein caspase-dependent pkr activation antigen-presenting dendritic cells fc receptor-mediated phagocytosis apoptotic jurkat cells–existence mfg-e8-deficient mice innate anti-inflammatory recognition tissue-repair gene expression early primary necrosis radiation-induced bystander effects ps-dependent phagocytic clearance monoclonal anti-phosphatidylserine antibody cd91 initiates macropinocytosis hepatocyte growth factors mediate hypoxia-initiated angiogenesis caspase-independent pathway serum-derived protein atp-induced maturation privacy choices/manage cookies tgf-beta released cytokine-independent survival neutrophils undergoing apoptosis proinflammatory macrophage transcription molecular biomedical research interleukin-12 gene expression monocyte-derived macrophages c-reactive protein p2y11 receptor mediates article apoptosis aims full article pdf programmed vascular regression marelli-berg fm protein synthesis persists cultured endothelial cells immunostimulatory dendritic cells dendritic cells charged gemcitabine strongly inhibits programmed cell death innate immune discrimination charnock-jones ds phosphatidylserine receptor protein induces autoantibody production

Questions {❓}

Berden JH (2003) Lupus nephritis:consequence of disturbed removal of apoptotic cells?
Giles KM, Hart SP, Haslett C, Rossi AG, Dransfield I (2000) An appetite for apoptotic cells?
Gregory CD, Devitt A (2004) The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?
Lorimore SA, Coates PJ, Scobie GE, Milne G, Wright EG (2001) Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?
Munoz LE, Gaipl US, Franz S, et al (2005) SLE-a disease of clearance deficiency?
Rittig MG, Wilske B, Krause A (1999) Phagocytosis of microorganisms by means of overshooting pseudopods: where do we stand?

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         description:The ultimate and most favorable fate of almost all dying cells is engulfment by neighboring or specialized cells. Efficient clearance of cells undergoing apoptotic death is crucial for normal tissue homeostasis and for the modulation of immune responses. Engulfment of apoptotic cells is finely regulated by a highly redundant system of receptors and bridging molecules on phagocytic cells that detect molecules specific for dying cells. Recognition of necrotic cells by phagocytes is less well understood than recognition of apoptotic cells, but an increasing number of recent studies, which are discussed here, are highlighting its importance. New observations indicate that the interaction of macrophages with dying cells initiates internalization of the apoptotic or necrotic targets, and that internalization can be preceded by “zipper”-like and macropinocytotic mechanisms, respectively. We emphasize that clearance of dying cells is an important fundamental process serving multiple functions in the regulation of normal tissue turnover and homeostasis, and is not just simple anti- or pro-inflammatory responses. Here we review recent findings on genetic pathways participating in apoptotic cell clearance, mechanisms of internalization, and molecules involved in engulfment of apoptotic versus necrotic cells, as well as their immunological consequences and relationships to disease pathogenesis.
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            Phosphatidylserine receptor
            Anticancer vaccines
            Cancer Research
            Cell Biology
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         Macropinocytosis
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         Phosphatidylserine receptor
         Anticancer vaccines
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         Biochemistry
         general
         Virology
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