We are analyzing https://link.springer.com/article/10.1007/s10495-006-5881-9.

Title:
Bioenergetic aspects of apoptosis, necrosis and mitoptosis | Apoptosis
Description:
In this review I summarize interrelations between bioenergetic processes and such programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial suicide (mitoptosis). The following conclusions are made. (I) ATP and rather often mitochondrial hyperpolarization (i.e. an increase in membrane potential, ΔΨ) are required for certain steps of apoptosis and necrosis. (II) Apoptosis, even if it is accompanied by ΔΨ and [ATP] increases at its early stage, finally results in a ΔΨ collapse and ATP decrease. (III) Moderate (about three-fold) lowering of [ATP] for short and long periods of time induces apoptosis and necrosis, respectively. In some types of apoptosis and necrosis, the cell death is mediated by a ΔΨ-dependent overproduction of ROS by the initial (Complex I) and the middle (Complex III) spans of the respiratory chain. ROS initiate mitoptosis which is postulated to rid the intracellular population of mitochondria from those that are ROS overproducing. Massive mitoptosis can result in cell death due to release to cytosol of the cell death proteins normally hidden in the mitochondrial intermembrane space.
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Topics {✒️}

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Questions {❓}

Apoptotic pathways: ten minutes to dead?
ROS production by mitochondria: function or dysfunction?
Sub-lethal signals in the mitochondrial apoptosis apparatus: pernicious by-product or physiological event?
To what end does nature produce superoxide?
Tumor necrosis factor: An apoptosis JuNKie?
Why are mitochondria involved in apoptosis?

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