We are analyzing https://link.springer.com/article/10.1007/s10495-006-0022-z.

Title:
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells | Apoptosis
Description:
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of caspase-3, although we found this caspase critical for ovarian granulosa cell death. Because of the mutual interdependence of germ cells and granulosa cells, herein we generated caspase-2 and -3 double-mutant (DKO) mice to evaluate how these two caspases functionally relate to each other in orchestrating oocyte apoptosis. No difference was observed in the rate of spontaneous oocyte apoptosis between DKO and wildtype (WT) females. In contrast, the oocytes from DKO females were more susceptible to apoptosis induced by DNA damaging agents, compared with oocytes from WT females. This increased sensitivity to death of DKO oocytes appears to be a specific response to DNA damage, and it was associated with a compensatory upregulation of caspase-12. Interestingly, DKO oocytes were more resistant to apoptosis induced by methotrexate (MTX) than WT oocytes. These results revealed that in female germ cells, insults that directly interfere with their metabolic status (e.g. MTX) require caspase-2 and caspase-3 as obligatory executioners of the ensuing cell death cascade. However, when DNA damage is involved, and in the absence of caspase-2 and -3, caspase-12 becomes upregulated and mediates apoptosis in oocytes.
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article, google, scholar, cas, pubmed, caspase, cell, apoptosis, death, tilly, cells, oocytes, germ, perez, research, jurisicova, human, department, flavell, access, differ, mol, university, matikainen, yuan, dko, reed, bcl, nature, usa, privacy, cookies, content, takai, mice, endoplasmic, reticulum, korsmeyer, family, bax, nat, gene, biology, data, information, publish, search, momoi, role, ovarian,

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month download article/chapter parental age-related aneuploidy female germ cells human germ cells aß-induced cell death full article pdf endoplasmic reticulum stress harvard medical school article apoptosis aims germ cells tunicamycin-treated cells privacy choices/manage cookies bcl-2 gene family chemotherapy-induced apoptosis related subjects massachusetts general hospital vincent research funds age-related decline doxorubicin-mediated death orchestrating oocyte apoptosis spontaneous oocyte apoptosis acid sphingomyelinase gene harakiri gene product mount sinai hospital caspase-3 activation correlates dna damaging agents granulosa cell apoptosis caspases functionally relate check access instant access critical control points ovarian cancer models apoptosis-related genes yale university school michigan state university apoptosis-based therapies european economic area scope submit manuscript basic biological phenomenon wide-ranging implications prenatal oogenesis advanced chronological age sphingosine-1-phosphate therapy porter ga jr acquired deleterious mutations investigator salary award ontario cancer institute conditions privacy policy granulosa cells analyzed mice lacking

Questions {❓}

Lim AST, Tsakok MFH (1997) Age-related decline in fertility: a link to degenerative oocytes?

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