We are analyzing https://link.springer.com/article/10.1007/s10456-015-9474-5.

Title:
Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer | Angiogenesis
Description:
Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro- or anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, roles of tumor-derived microRNAs in regulating tumor vascularization remain to be elucidated. In this study, we found that delivery of miR-494 into human vascular endothelial cells (ECs) enhanced the EC migration and promoted angiogenesis. The angiogenic effect of miR-494 was mediated by the targeting of PTEN and the subsequent activation of Akt/eNOS pathway. Importantly, co-culture experiments demonstrated that a lung cancer cell line, A549, secreted and delivered miR-494 into ECs via a microvesicle-mediated route. In addition, we found that the expression of miR-494 was induced in the tumor cells in response to hypoxia, likely via a HIF-1α-mediated mechanism. Furthermore, a specific miR-494 antagomiR effectively inhibited angiogenesis and attenuated the growth of tumor xenografts in nude mice. Taken together, these results demonstrated that miR-494 is a novel tumor-derived paracrine signal to promote angiogenesis and tumor growth under hypoxic condition.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, angiogenesis, wang, central, cell, liu, microrna, cells, tumor, chen, lung, endothelial, res, expression, zhang, fang, access, angiogenic, targeting, microvesicles, privacy, cookies, content, tumorderived, nonsmall, growth, human, doican, publish, research, search, promotes, mao, nanping, micrornas, vascular, pten, induced, hypoxia, open, sci, stem, science, china, data,

Topics {✒️}

ischemia/reperfusion-induced cardiac injury month download article/chapter small-cell lung cancer tumor-derived paracrine signal balloon-injured rat arteries c-jun triggers apoptosis hif-1α-mediated mechanism article angiogenesis aims modulates trail-induced apoptosis mir-200b targets ets-1 micro-rna expression profiles full article pdf hypoxia-induced microrna-424 expression related subjects microrna-1246 promote angiogenesis nuclear receptor pxr lung premetastatic niche privacy choices/manage cookies tumor-derived microvesicles targeting c-myc tumor suppressor phosphatase hif-1alpha expression tumor-endothelial cell vitro angiogenesis induced endothelial cells create endothelial cells exposed promotes angiogenesis tumor-derived micrornas microvesicle-mediated route toxicol environ health stem cell niche prospective cancer biomarkers mir-21 induced angiogenesis article mao transformed beas2b cells lung cancer modulate angiogenic processes critical angiogenic factors radon-induced alterations article log european economic area lianjun lin classical hodgkin lymphoma hydrogel bioengineered tumors tissue eng part providing notch ligands antiapoptotic proteins protects microenvironment modulators mediates mitochondrial alterations national science foundation

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer
         description:Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro- or anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, roles of tumor-derived microRNAs in regulating tumor vascularization remain to be elucidated. In this study, we found that delivery of miR-494 into human vascular endothelial cells (ECs) enhanced the EC migration and promoted angiogenesis. The angiogenic effect of miR-494 was mediated by the targeting of PTEN and the subsequent activation of Akt/eNOS pathway. Importantly, co-culture experiments demonstrated that a lung cancer cell line, A549, secreted and delivered miR-494 into ECs via a microvesicle-mediated route. In addition, we found that the expression of miR-494 was induced in the tumor cells in response to hypoxia, likely via a HIF-1α-mediated mechanism. Furthermore, a specific miR-494 antagomiR effectively inhibited angiogenesis and attenuated the growth of tumor xenografts in nude mice. Taken together, these results demonstrated that miR-494 is a novel tumor-derived paracrine signal to promote angiogenesis and tumor growth under hypoxic condition.
         datePublished:2015-06-04T00:00:00Z
         dateModified:2015-06-04T00:00:00Z
         pageStart:373
         pageEnd:382
         sameAs:https://doi.org/10.1007/s10456-015-9474-5
         keywords:
            miR-494
            Angiogenesis
            Non-small cell lung cancer
            Microvesicle
            Cancer Research
            Biomedicine
            general
            Cell Biology
            Cardiology
            Ophthalmology
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig6_HTML.gif
         isPartOf:
            name:Angiogenesis
            issn:
               1573-7209
               0969-6970
            volumeNumber:18
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Guangmei Mao
               affiliation:
                     name:Peking University Health Science Center
                     address:
                        name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yan Liu
               affiliation:
                     name:Peking University Health Science Center
                     address:
                        name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xi Fang
               affiliation:
                     name:Peking University Health Science Center
                     address:
                        name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yahan Liu
               affiliation:
                     name:Peking University Health Science Center
                     address:
                        name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li Fang
               affiliation:
                     name:Peking University Health Science Center
                     address:
                        name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lianjun Lin
               affiliation:
                     name:Peking University First Hospital
                     address:
                        name:Geriatric Department, Peking University First Hospital, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xinmin Liu
               affiliation:
                     name:Peking University First Hospital
                     address:
                        name:Geriatric Department, Peking University First Hospital, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nanping Wang
               affiliation:
                     name:Peking University Health Science Center
                     address:
                        name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Xi’an Jiaotong University
                     address:
                        name:Cardiovascular Research Center, Xi’an Jiaotong University, Xi’an, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer
      description:Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro- or anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, roles of tumor-derived microRNAs in regulating tumor vascularization remain to be elucidated. In this study, we found that delivery of miR-494 into human vascular endothelial cells (ECs) enhanced the EC migration and promoted angiogenesis. The angiogenic effect of miR-494 was mediated by the targeting of PTEN and the subsequent activation of Akt/eNOS pathway. Importantly, co-culture experiments demonstrated that a lung cancer cell line, A549, secreted and delivered miR-494 into ECs via a microvesicle-mediated route. In addition, we found that the expression of miR-494 was induced in the tumor cells in response to hypoxia, likely via a HIF-1α-mediated mechanism. Furthermore, a specific miR-494 antagomiR effectively inhibited angiogenesis and attenuated the growth of tumor xenografts in nude mice. Taken together, these results demonstrated that miR-494 is a novel tumor-derived paracrine signal to promote angiogenesis and tumor growth under hypoxic condition.
      datePublished:2015-06-04T00:00:00Z
      dateModified:2015-06-04T00:00:00Z
      pageStart:373
      pageEnd:382
      sameAs:https://doi.org/10.1007/s10456-015-9474-5
      keywords:
         miR-494
         Angiogenesis
         Non-small cell lung cancer
         Microvesicle
         Cancer Research
         Biomedicine
         general
         Cell Biology
         Cardiology
         Ophthalmology
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10456-015-9474-5/MediaObjects/10456_2015_9474_Fig6_HTML.gif
      isPartOf:
         name:Angiogenesis
         issn:
            1573-7209
            0969-6970
         volumeNumber:18
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Guangmei Mao
            affiliation:
                  name:Peking University Health Science Center
                  address:
                     name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan Liu
            affiliation:
                  name:Peking University Health Science Center
                  address:
                     name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xi Fang
            affiliation:
                  name:Peking University Health Science Center
                  address:
                     name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yahan Liu
            affiliation:
                  name:Peking University Health Science Center
                  address:
                     name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li Fang
            affiliation:
                  name:Peking University Health Science Center
                  address:
                     name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lianjun Lin
            affiliation:
                  name:Peking University First Hospital
                  address:
                     name:Geriatric Department, Peking University First Hospital, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xinmin Liu
            affiliation:
                  name:Peking University First Hospital
                  address:
                     name:Geriatric Department, Peking University First Hospital, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nanping Wang
            affiliation:
                  name:Peking University Health Science Center
                  address:
                     name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Xi’an Jiaotong University
                  address:
                     name:Cardiovascular Research Center, Xi’an Jiaotong University, Xi’an, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Angiogenesis
      issn:
         1573-7209
         0969-6970
      volumeNumber:18
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Peking University Health Science Center
      address:
         name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
         type:PostalAddress
      name:Peking University Health Science Center
      address:
         name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
         type:PostalAddress
      name:Peking University Health Science Center
      address:
         name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
         type:PostalAddress
      name:Peking University Health Science Center
      address:
         name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
         type:PostalAddress
      name:Peking University Health Science Center
      address:
         name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
         type:PostalAddress
      name:Peking University First Hospital
      address:
         name:Geriatric Department, Peking University First Hospital, Beijing, China
         type:PostalAddress
      name:Peking University First Hospital
      address:
         name:Geriatric Department, Peking University First Hospital, Beijing, China
         type:PostalAddress
      name:Peking University Health Science Center
      address:
         name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
         type:PostalAddress
      name:Xi’an Jiaotong University
      address:
         name:Cardiovascular Research Center, Xi’an Jiaotong University, Xi’an, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Guangmei Mao
      affiliation:
            name:Peking University Health Science Center
            address:
               name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yan Liu
      affiliation:
            name:Peking University Health Science Center
            address:
               name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
               type:PostalAddress
            type:Organization
      name:Xi Fang
      affiliation:
            name:Peking University Health Science Center
            address:
               name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yahan Liu
      affiliation:
            name:Peking University Health Science Center
            address:
               name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
               type:PostalAddress
            type:Organization
      name:Li Fang
      affiliation:
            name:Peking University Health Science Center
            address:
               name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
               type:PostalAddress
            type:Organization
      name:Lianjun Lin
      affiliation:
            name:Peking University First Hospital
            address:
               name:Geriatric Department, Peking University First Hospital, Beijing, China
               type:PostalAddress
            type:Organization
      name:Xinmin Liu
      affiliation:
            name:Peking University First Hospital
            address:
               name:Geriatric Department, Peking University First Hospital, Beijing, China
               type:PostalAddress
            type:Organization
      name:Nanping Wang
      affiliation:
            name:Peking University Health Science Center
            address:
               name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
               type:PostalAddress
            type:Organization
            name:Xi’an Jiaotong University
            address:
               name:Cardiovascular Research Center, Xi’an Jiaotong University, Xi’an, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
      name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
      name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
      name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
      name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
      name:Geriatric Department, Peking University First Hospital, Beijing, China
      name:Geriatric Department, Peking University First Hospital, Beijing, China
      name:Institute of Cardiovascular Science, Peking University Health Science Center, Beijing, China
      name:Cardiovascular Research Center, Xi’an Jiaotong University, Xi’an, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(211)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.63s.

LINK . SPRINGER . COM {}