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Title:
Nanotechnology for Cell–Substrate Interactions | Annals of Biomedical Engineering
Description:
In the pursuit to understand the interaction between cells and their underlying substrates, the life sciences are beginning to incorporate micro- and nanotechnology-based tools to probe and measure cells. The development of these tools portends endless possibilities for new insights into the fundamental relationships between cells and their surrounding microenvironment that underlie the physiology of human tissue. Here, we review techniques and tools that have been used to study how a cell responds to the physical factors in its environment. We also discuss unanswered questions that could be addressed by these approaches to better elucidate the molecular processes and mechanical forces that dominate the interactions between cells and their physical scaffolds.
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google, scholar, cas, pubmed, article, cell, cells, biol, wang, whitesides, ingber, sci, focal, chen, forces, biophys, usa, res, science, adhesion, force, natl, proc, acad, physiol, control, mechanical, dembo, adhesions, sheetz, matrix, monolayers, gradients, traction, substrates, fibroblasts, chem, langmuir, nature, human, exp, mechanotransduction, rev, mol, substrata, shape, endothelial, mrksich, content, research,
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month download article/chapter alpha5beta1 integrin-fibronectin interaction single vinculin-deficient cells micropatterning tractional forces rho-stimulated contractility drives initial integrin-cytoskeleton bonds sami alom ruiz & christopher rgd-derivatized polyacrylamide substrata nano-structured surface features surface-bound fibronectin gradients flow-mediated endothelial mechanotransduction extracellular matrix geometry studying actin-dependent processes full article pdf smooth muscle cells privacy choices/manage cookies extracellular matrix rigidity related subjects van de water adherent cells probed patterned protein layers single-molecule afm single cell mechanotransduction matrix adhesion molecules engineering cell shape cell-matrix adhesions biomedical engineering aims nanotechnology-based tools atomic force microscope undergo rearward translocation nascent focal adhesions constraining cell shape focal adhesion assembly focal adhesion sites focal adhesion kinase rgd-modified substrata epithelial contact guidance human endothelium orientation basement membrane underlying cyclic amp signalling adhesion ligands varied integrin-cytoskeleton linkages actin filament bundles polymer imprint lithography collagen surface density force-dependent reinforcement nerve growth factor atomic force microscopy protein nanoarrays generated protein-protein dynamics
Questions {❓}
- Patterning self-assembled monolayers using microcontact printing: A new technology for biosensors?
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headline:Nanotechnology for Cell–Substrate Interactions
description:In the pursuit to understand the interaction between cells and their underlying substrates, the life sciences are beginning to incorporate micro- and nanotechnology-based tools to probe and measure cells. The development of these tools portends endless possibilities for new insights into the fundamental relationships between cells and their surrounding microenvironment that underlie the physiology of human tissue. Here, we review techniques and tools that have been used to study how a cell responds to the physical factors in its environment. We also discuss unanswered questions that could be addressed by these approaches to better elucidate the molecular processes and mechanical forces that dominate the interactions between cells and their physical scaffolds.
datePublished:2006-03-09T00:00:00Z
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Cell shape
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Focal Adhesions
Integrins
Mechanotransduction
Micropatterning
Nanotopology
Self-Assembled Monolayers (SAMs)
Traction Forces
Biomedicine
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Biological and Medical Physics
Biophysics
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Biochemistry
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headline:Nanotechnology for Cell–Substrate Interactions
description:In the pursuit to understand the interaction between cells and their underlying substrates, the life sciences are beginning to incorporate micro- and nanotechnology-based tools to probe and measure cells. The development of these tools portends endless possibilities for new insights into the fundamental relationships between cells and their surrounding microenvironment that underlie the physiology of human tissue. Here, we review techniques and tools that have been used to study how a cell responds to the physical factors in its environment. We also discuss unanswered questions that could be addressed by these approaches to better elucidate the molecular processes and mechanical forces that dominate the interactions between cells and their physical scaffolds.
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Cell shape
Extracellular Matrix
Focal Adhesions
Integrins
Mechanotransduction
Micropatterning
Nanotopology
Self-Assembled Monolayers (SAMs)
Traction Forces
Biomedicine
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Biological and Medical Physics
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