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Title:
An Introductory Review of Cell Mechanobiology | Biomechanics and Modeling in Mechanobiology
Description:
Mechanical loads induce changes in the structure, composition, and function of living tissues. Cells in tissues are responsible for these changes, which cause physiological or pathological alterations in the extracellular matrix (ECM). This article provides an introductory review of the mechanobiology of load-sensitive cells in vivo, which include fibroblasts, chondrocytes, osteoblasts, endothelial cells, and smooth muscle cells. Many studies have shown that mechanical loads affect diverse cellular functions, such as cell proliferation, ECM gene and protein expression, and the production of soluble factors. Major cellular components involved in the mechanotransduction mechanisms include the cytoskeleton, integrins, G proteins, receptor tyrosine kinases, mitogen-activated protein kinases, and stretch-activated ion channels. Future research in the area of cell mechanobiology will require novel experimental and theoretical methodologies to determine the type and magnitude of the forces experienced at the cellular and sub-cellular levels and to identify the force sensors/receptors that initiate the cascade of cellular and molecular events
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Keywords {🔍}

google, scholar, pubmed, article, cell, mechanical, cells, matrix, res, biol, smooth, muscle, physiol, strain, extracellular, tissue, growth, endothelial, vascular, collagen, human, mechanotransduction, expression, cyclic, wang, fibroblasts, cartilage, synthesis, response, regulation, stress, biochem, cellular, metalloproteinases, mechanobiology, vitro, cardiac, molecular, signaling, stretch, orthop, biomech, eng, dynamic, review, protein, role, rev, transduction, curr,

Topics {✒️}

gbeta/gamma-dependent signaling pathways tyrosine-kinase dependent tgf-beta month download article/chapter n-terminal jun kinase chick limb-bud cells mitogen-activated protein kinases fluid-induced shear stress integrin-mediated echanotransduction requires protein-serine/threonine kinases shear stress-induced release growth factor-binding protein-3 stretch-activated ion channels stretch-activated cation channel stress-activated protein kinases platelet-derived growth factor tissue-cultured chick heart transforming growth factor-beta stretch-sensitive ion channels vascular smooth muscle extracellular signal-regulated kinase mechanical strain-induced proliferation stretch-induced collagen synthesis chondrocyte-seeded agarose hydrogels tumor necrosis factor-alpha protein tyrosine phosphorylation extracellular signal-regulated kinases chondrocyte-seeded agarose gels smooth muscle cells local renin-angiotensin system bi-directional signal transduction collagen superfamily–diverse structures integrin-cytoskeletal interactions mechanical stretch activates mapk signaling pathways fluid shear stress agarose constructs subjected receptor tyrosine kinases human-derived osteoblast flow-mediated endothelial mechanotransduction human endothelial cells full article pdf repetitive mechanical stretching cyclic uniaxial stretching pulmonary artery tissue cyclic substrate strains vascular endothelial cells cyclic mechanical stretching growth factor signaling cyclic strain-mediated regulation time-dependent increases

Questions {❓}

Chao MV (1992) Growth factor signaling: where is the specificity?

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            Biological and Medical Physics
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