We are analyzing https://link.springer.com/article/10.1007/s10151-013-1106-8.

Title:
Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome | Techniques in Coloproctology
Description:
Background Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal discomfort, pain and changes in bowel habits, often associated with psychological/psychiatric disorders. It has been suggested that the development of IBS may be related to the body’s response to stress, which is one of the main factors that can modulate motility and visceral perception through the interaction between brain and gut (brain–gut axis). The present review will examine and discuss the role of serotonin (5-hydroxytryptamine, 5-HT) receptor subtypes in the pathophysiology and therapy of IBS. Methods Search of the literature published in English using the PubMed database. Results Several lines of evidence indicate that 5-HT and its receptor subtypes are likely to have a central role in the pathophysiology of IBS. 5-HT released from enterochromaffin cells regulates sensory, motor and secretory functions of the digestive system through the interaction with different receptor subtypes. It has been suggested that pain signals originate in intrinsic primary afferent neurons and are transmitted by extrinsic primary afferent neurons. Moreover, IBS is associated with abnormal activation of central stress circuits, which results in altered perception during visceral stimulation. Conclusions Altered 5-HT signaling in the central nervous system and in the gut contributes to hypersensitivity in IBS. The therapeutic effects of 5-HT agonists/antagonists in IBS are likely to be due also to the ability to modulate visceral nociception in the central stress circuits. Further studies are needed in order to develop an optimal treatment.
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pubmed, google, scholar, cas, bowel, receptor, irritable, syndrome, serotonin, central, receptors, pharmacol, brain, human, gut, hydroxytryptamine, gastroenterology, article, visceral, patients, rat, role, pain, sci, res, review, ibs, gastrointestinal, subtypes, antagonist, camilleri, hta, stasi, functional, effects, gastroenterol, ther, search, sensory, physiol, neurogastroenterol, motil, clinical, italy, privacy, cookies, content, bellini, disorders, modulate,

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alpha-[11c]methyl-l-tryptophan altered neuro-endocrine-immune pathways central nervous system month download article/chapter digestive system gastrointestinal sensory disorders spinal c-fos expression interdigestive gastrointestinal motility irritable bowel syndrome 5-ht1b/1d receptor agonists brain–gut axis gastrointestinal tract characterized gastrointestinal disorders central stress circuits rat stomach fundus privacy choices/manage cookies increased gut permeability psychological/psychiatric disorders colonic mucosal 5-ht 5-ht4 receptor agonist constipation predominant subjects basic pathophysiologic mechanisms full article pdf acute campilobacter enteris altered 5-hydroxytryptamine signaling physiology antidepressant drug action van heuven-nolsen gut pacemaker cells express 5-hydroxytryptamine1a receptors 5-ht7 serotonin receptors human serotonin receptor gershon md 5-ht4 agonists developed selective 5-hydroxytryptamine receptor pubmed database rat spinal cord spinal cord injury brain serotonin synthesis exaggerated sensory component delays colonic transit slowing colonic transit european economic area scope submit manuscript bovine cerebral arteries phos-phoinositide turnover tracheal smooth muscle cardiovascular safety profile noxious colorectal distension positron emission tomography

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         description:Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal discomfort, pain and changes in bowel habits, often associated with psychological/psychiatric disorders. It has been suggested that the development of IBS may be related to the body’s response to stress, which is one of the main factors that can modulate motility and visceral perception through the interaction between brain and gut (brain–gut axis). The present review will examine and discuss the role of serotonin (5-hydroxytryptamine, 5-HT) receptor subtypes in the pathophysiology and therapy of IBS. Search of the literature published in English using the PubMed database. Several lines of evidence indicate that 5-HT and its receptor subtypes are likely to have a central role in the pathophysiology of IBS. 5-HT released from enterochromaffin cells regulates sensory, motor and secretory functions of the digestive system through the interaction with different receptor subtypes. It has been suggested that pain signals originate in intrinsic primary afferent neurons and are transmitted by extrinsic primary afferent neurons. Moreover, IBS is associated with abnormal activation of central stress circuits, which results in altered perception during visceral stimulation. Altered 5-HT signaling in the central nervous system and in the gut contributes to hypersensitivity in IBS. The therapeutic effects of 5-HT agonists/antagonists in IBS are likely to be due also to the ability to modulate visceral nociception in the central stress circuits. Further studies are needed in order to develop an optimal treatment.
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