We are analyzing https://link.springer.com/article/10.1007/s10147-021-02074-9.

Title:
Key promoters of tumor hallmarks | International Journal of Clinical Oncology
Description:
Evolution of tumor hallmarks is a result of accommodation of tumor cells with their nearby milieu called tumor microenvironment (TME). Accommodation or adaptive responses is highly important for a cell to survive, without which no cell is allowed to take any further steps in tumorigenesis. Metabolism of cancer cells is largely depended on stroma. Composition and plasticity of cells within the stroma is highly affected from inflammatory setting of TME. Hypoxia which is a common event in many solid cancers, is known as one of the key hallmarks of chronic inflammation and the master regulator of metastasis. Transforming growth factor (TGF)-β is produced in the chronic inflammatory and chronic hypoxic settings, and it is considered as a cardinal factor for induction of all tumor hallmarks. Aging, obesity and smoking are the main predisposing factors of cancer, acting mainly through modulation of TME.
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Keywords {🔍}

pubmed, google, scholar, article, cancer, cas, central, cell, tumor, nat, rev, trends, mortezaee, metastasis, cells, microenvironment, growth, mol, therapy, biol, immunol, immunity, oncol, cancerassociated, breast, clin, immune, progression, fibroblasts, majidpoor, tgfβ, tumour, signaling, targeting, commun, plasticity, sci, metabolic, pancreatic, res, med, reprogramming, hypoxia, inflammation, target, review, angiogenesis, najafi, nature, carcinoma,

Topics {✒️}

bifunctional anti-pd-l1/tgf-βrii agent c-met/fra1/hey1 signaling month download article/chapter exploring anti-tgf-β therapies transforming growth factor myeloid-derived suppressor cells ar-independent prostate carcinoma vegf-induced vascular permeability effective anti-metastatic agents drive poor-prognosis subtypes inducing macrophage polarization tgf-β1 receptor type cxcr4/sdf-1 axis immunomodulatory tgf-β signaling registry-based 20-year data yap-mediated transcriptional reprogramming metastasis-initiating cells induce crispr/cas9 targeting telomeres pd-1/pd-l1 blockade article international journal aid hypoxia-targeted therapy full article pdf treatment-induced tumor dormancy cancer-acquired drug resistance mir-155 harnesses phf19 solid tumors-clinical perspectives tumor immunology chronic hypoxic settings tumour growth privacy choices/manage cookies cxcl5/cxcr2 axis article mortezaee de groot ae cancer immunotherapy-clinical perspectives targeting cancer-related inflammation tumor–stroma metabolic crosstalk hypoxia induces core gut–brain axis colon cancer growth keywan mortezaee doxorubicin-induced cardiotoxicity induced synthetic lethality cancer stem cell fuel malignant colonization tumour dormancy de visser ke pas de deux breast cancer malignancy human colorectal cancer tumour hypoxia

Questions {❓}

Diepenbruck M, Christofori G (2016) Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?
Hermann PC, Sainz Jr B (2018) Pancreatic cancer stem cells: a state or an entity?
Reinehr T (2020) Obesity in adolescents and cancer risk: causal relationship or epiphenomenon?
Wolter K, Zender L (2020) Therapy-induced senescence—an induced synthetic lethality in liver cancer?

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