We are analyzing https://link.springer.com/article/10.1007/s10120-010-0554-3.

Title:
High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer | Gastric Cancer
Description:
Background The neutrophil-lymphocyte ratio (NLR) reflects inflammatory status. An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer. Methods A total of 709 men and 319 women, with a mean age of 64.4 years, who underwent gastrectomy were included. The numbers of patients in each pathological stage were as follows: stage I, 584; stage II, 132; stage III, 153; and stage IV, 159. The mean NLR was 2.62 ± 1.68. A total of 127 patients (12.4%) with an NLR of 4.0 or more were classified as high NLR individuals in this study. The prognostic significance of a high NLR, together with various clinicopathological factors, was evaluated by multivariate analysis. Results The 5-year survival of patients with a high NLR was significantly worse than that of patients with a low NLR (57% vs 82%, P < 0.001). Univariate and multivariate analyses of clinicopathological factors affecting survival revealed that high NLR, depth of tumor, positive lymph nodes, distant metastasis, peritoneal metastasis, poorly differentiated type, and high platelet count were significant risk factors for reduced survival. On multivariate analysis, after adjusting for tumor stage, a high NLR was an independent risk factor for reduced survival (P = 0.003; adjusted hazard ratio, 1.845; 95% confidence interval, 1.236–2.747). Conclusion A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for primary gastric cancer.
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small-cell lung cancer lymphokine-activated killer induction neutrophil-lymphocyte ratio neutrophil/lymphocyte ratio elevated preoperative neutrophil primary gastric cancer early gastric cancer advanced gastric cancer independent prognostic factor gastric cancer patients search search high preoperative nlr privacy choices/manage cookies related subjects independent risk factor pretreatment neutrophil count preoperative neutrophil long-term survival gastric cancer gastric cancer 1998 gastric cancer 13 adjusted hazard ratio advanced colorectal cancer chiba cancer center article shimada high nlr individuals significant risk factors prognostic factor postoperative neutrophil high platelet count european economic area reflects inflammatory status positive lymph nodes poorly differentiated type von der maase torp madsen hh american joint committee toho university school lymphocyte ratio poor prognosis conditions privacy policy colorectal liver metastases alpha fetoprotein levels accepting optional cookies stage ii tumour biol 1999 tumour biol 1998 article cite lymphocyte count journal finder publish

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         headline:High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer
         description:The neutrophil-lymphocyte ratio (NLR) reflects inflammatory status. An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer. A total of 709 men and 319 women, with a mean age of 64.4 years, who underwent gastrectomy were included. The numbers of patients in each pathological stage were as follows: stage I, 584; stage II, 132; stage III, 153; and stage IV, 159. The mean NLR was 2.62 ± 1.68. A total of 127 patients (12.4%) with an NLR of 4.0 or more were classified as high NLR individuals in this study. The prognostic significance of a high NLR, together with various clinicopathological factors, was evaluated by multivariate analysis. The 5-year survival of patients with a high NLR was significantly worse than that of patients with a low NLR (57% vs 82%, P < 0.001). Univariate and multivariate analyses of clinicopathological factors affecting survival revealed that high NLR, depth of tumor, positive lymph nodes, distant metastasis, peritoneal metastasis, poorly differentiated type, and high platelet count were significant risk factors for reduced survival. On multivariate analysis, after adjusting for tumor stage, a high NLR was an independent risk factor for reduced survival (P = 0.003; adjusted hazard ratio, 1.845; 95% confidence interval, 1.236–2.747). A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for primary gastric cancer.
         datePublished:2010-09-05T00:00:00Z
         dateModified:2010-09-05T00:00:00Z
         pageStart:170
         pageEnd:176
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            Gastric cancer
            Survival
            Surgical Oncology
            Oncology
            Abdominal Surgery
            Gastroenterology
            Cancer Research
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      headline:High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer
      description:The neutrophil-lymphocyte ratio (NLR) reflects inflammatory status. An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer. A total of 709 men and 319 women, with a mean age of 64.4 years, who underwent gastrectomy were included. The numbers of patients in each pathological stage were as follows: stage I, 584; stage II, 132; stage III, 153; and stage IV, 159. The mean NLR was 2.62 ± 1.68. A total of 127 patients (12.4%) with an NLR of 4.0 or more were classified as high NLR individuals in this study. The prognostic significance of a high NLR, together with various clinicopathological factors, was evaluated by multivariate analysis. The 5-year survival of patients with a high NLR was significantly worse than that of patients with a low NLR (57% vs 82%, P < 0.001). Univariate and multivariate analyses of clinicopathological factors affecting survival revealed that high NLR, depth of tumor, positive lymph nodes, distant metastasis, peritoneal metastasis, poorly differentiated type, and high platelet count were significant risk factors for reduced survival. On multivariate analysis, after adjusting for tumor stage, a high NLR was an independent risk factor for reduced survival (P = 0.003; adjusted hazard ratio, 1.845; 95% confidence interval, 1.236–2.747). A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for primary gastric cancer.
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      dateModified:2010-09-05T00:00:00Z
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      pageEnd:176
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         Neutrophil-lymphocyte ratio
         Gastric cancer
         Survival
         Surgical Oncology
         Oncology
         Abdominal Surgery
         Gastroenterology
         Cancer Research
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      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
      name:Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan

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