We are analyzing https://link.springer.com/article/10.1007/s10072-021-05835-6.

Title:
The role of efferocytosis in neuro-degenerative diseases | Neurological Sciences
Description:
Efferocytosis has a critical role in maintaining tissues and organs’ homeostasis by removing apoptotic cells. It is essential for human health, and disturbances in efferocytosis may result indifferent illnesses. In case of inadequate clearance of the dead cells, the content in the cells would be released. In fact, it induces some damages to the tissue and leads to the prolonged inflammation, so unsuitable phagocytosis of the apoptotic cells is involved in occurrence as well as expansion of numerous human chronic inflammatory diseases. Studies have shown age dependence of the neuro-degenerative diseases, which are largely due to the neuro-inflammation and the loss of neurons and thus cause the brain’s functional disorders. Efferocytosis is coupled to anti-inflammatory responses that contribute to the elimination of the dying neurons in neuro-degenerative diseases, so its disruption may make a risk factor in numerous human chronic inflammatory diseases such as multiple sclerosis, Alzheimer’s disease, glioblastoma, and Rett syndrome. This study is a review of the efferocytosis molecular pathways and their role in neuro-degenerative diseases in order to discover a new treatment option to cure patients.
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pubmed, article, google, scholar, cas, central, disease, cells, cell, apoptotic, diseases, microglia, neurodegenerative, clearance, alzheimers, biol, efferocytosis, phagocytosis, immunol, role, neurol, sclerosis, microglial, huntingtons, neurosci, mouse, sciences, human, neurodegeneration, parkinsons, receptor, exp, nature, model, medical, function, factor, access, amyotrophic, lateral, nat, front, content, research, neuroinflammation, molecular, rev, apoptosis, activation, macrophages,

Topics {✒️}

seyed mohammad gheibihayat activating axl/hsp90/pparγ pathway alpha-synuclein oligomers—neurotoxic molecules month download article/chapter pro-inflammatory cytokines released n-terminal tail domain elmo/dock180/rac module peripheral tgf-β1 depend neuro-degenerative diseases neonatal brain hypoxia-ischemia brain-resident microglia predominate lyso-phosphatidyl-choline cx3cl1 myeloid lineage-determining factors anti-inflammatory mechanisms triggered central nervous system molecular research center vitronectin receptor-mediated phagocytosis xk-related protein 8 α-synuclein wave2 full article pdf chronic inflammatory diseases appsw transgenic mice privacy choices/manage cookies jamshid gholizadeh navashenaq related subjects ameliorates cognitive deficiency author correspondence triggering receptor expressed amyotrophic lateral sclerosis promotes aβ clearance membrane-binding property monocytes-derived macrophages spinal cord cd8 article taheri cns neurodegenerative diseases mitochondrial fission promotes phagocyte receptor g2a plasma inflammatory biomarkers immune cell function additional information publisher apoptotic cell clearance efferocytosis mediated modulation central player neurotoxic microglial phenotype anti-inflammatory responses apoptotic cell sensing check access instant access stimulate macrophage chemotaxis wave2 complex stabilization

Questions {❓}

Chauhan A, Jeans AF (2015) Is Parkinson’s disease truly a prion-like disorder?

Schema {🗺️}

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