We are analyzing https://link.springer.com/article/10.1007/s10067-014-2569-3.

Title:
In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up | Clinical Rheumatology
Description:
This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n = 90) were included prospectively and followed up for 1 year, and a comparison group of RA cases (n = 70) was also included. At study entry in all patients in both groups, RF and anti-CCP antibodies were tested, and the findings were compared and correlated. In the PR group at presentation, RF was positive in 30 patients (33.3 %) and, in the RA group, in 45 patients (64.3 %). Anti-CCP antibodies were positive in 35 patients (38.9 %) with PR and in 58 patients (82.9 %) with RA. In the PR group, positive correlations were observed between RF and C-reactive protein (CRP) (p = 0.036), while anti-CCP positively correlated with disease duration (p = 0.015) and CRP (p < 0.001). At 1-year follow-up, 25 cases (27.5 %) had progressed to RA, 3 (3.3 %) cases had developed systemic lupus, 43 cases had responded to hydroxychloroquine with complete remission, five cases had developed other rheumatic diseases, and 14 cases had progressed to undifferentiated arthritis. After regression analysis, the involvement of hand joints and positive anti-CCP were the only predictors that determined progression into RA within a year (p < 0.001 and p = 0.02, respectively). Early hand joint involvement and positive anti-CCP at disease onset are good predictors for progression to RA in this domain.
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Keywords {🔍}

arthritis, article, google, scholar, pubmed, rheumatoid, rheumatism, palindromic, patients, antibodies, citrullinated, rheumatol, peptide, cas, anticcp, anticyclic, clinical, positive, cases, van, cairo, rheumatology, emad, study, disease, rheum, joint, year, progression, undifferentiated, medicine, department, university, privacy, cookies, content, involvement, development, factor, egypt, publish, search, hand, followup, yasser, aboelyoun, group, protein, early, access,

Topics {✒️}

understanding gene/environment/immunity interactions month download article/chapter anti-cyclic citrullinated peptide van der horst-bruinsma anti-modified citrullinated vimentin cyclic citrullinated peptide hla-drb1 shared epitope anti-ccp positively correlated hadeel al-hanafi van der woude rheumatic diseases ihab abo-elyoun nashwa el-shaarawy full article pdf anti-ccp antibodies connective tissue diseases positive anti-ccp privacy choices/manage cookies original article published rheumatology/european league van venrooij wj c-reactive protein related subjects chemical pathology department vimentin-derived acpa ccp high sensitive article emad cytokine gene polymorphisms roret gene family hand joint involvement european economic area linn-rasker sp genetic background implies familial mediterranean fever bagedo general hospital yasser emad juvenile idiopathic arthritis de jong ba suez canal university cañete jd conditions privacy policy de koning mh long term outcomes gómez-puerta ja international fmf consortium gamez-nava ji rheumatism collaborative initiative onset rheumatoid arthritis distinct disease entity mefv gene mutations

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An abortive form of rheumatoid arthritis?

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         headline:In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up
         description:This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n = 90) were included prospectively and followed up for 1 year, and a comparison group of RA cases (n = 70) was also included. At study entry in all patients in both groups, RF and anti-CCP antibodies were tested, and the findings were compared and correlated. In the PR group at presentation, RF was positive in 30 patients (33.3 %) and, in the RA group, in 45 patients (64.3 %). Anti-CCP antibodies were positive in 35 patients (38.9 %) with PR and in 58 patients (82.9 %) with RA. In the PR group, positive correlations were observed between RF and C-reactive protein (CRP) (p = 0.036), while anti-CCP positively correlated with disease duration (p = 0.015) and CRP (p < 0.001). At 1-year follow-up, 25 cases (27.5 %) had progressed to RA, 3 (3.3 %) cases had developed systemic lupus, 43 cases had responded to hydroxychloroquine with complete remission, five cases had developed other rheumatic diseases, and 14 cases had progressed to undifferentiated arthritis. After regression analysis, the involvement of hand joints and positive anti-CCP were the only predictors that determined progression into RA within a year (p < 0.001 and p = 0.02, respectively). Early hand joint involvement and positive anti-CCP at disease onset are good predictors for progression to RA in this domain.
         datePublished:2014-03-13T00:00:00Z
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            Palindromic rheumatism (PR)
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            Rheumatology
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      headline:In palindromic rheumatism, hand joint involvement and positive anti-CCP antibodies predict RA development after 1 year of follow-up
      description:This study aimed to determine the frequency of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies in a cohort of patients with palindromic rheumatism (PR) and to find determinants for progression to rheumatoid arthritis (RA). All new cases of PR (n = 90) were included prospectively and followed up for 1 year, and a comparison group of RA cases (n = 70) was also included. At study entry in all patients in both groups, RF and anti-CCP antibodies were tested, and the findings were compared and correlated. In the PR group at presentation, RF was positive in 30 patients (33.3 %) and, in the RA group, in 45 patients (64.3 %). Anti-CCP antibodies were positive in 35 patients (38.9 %) with PR and in 58 patients (82.9 %) with RA. In the PR group, positive correlations were observed between RF and C-reactive protein (CRP) (p = 0.036), while anti-CCP positively correlated with disease duration (p = 0.015) and CRP (p < 0.001). At 1-year follow-up, 25 cases (27.5 %) had progressed to RA, 3 (3.3 %) cases had developed systemic lupus, 43 cases had responded to hydroxychloroquine with complete remission, five cases had developed other rheumatic diseases, and 14 cases had progressed to undifferentiated arthritis. After regression analysis, the involvement of hand joints and positive anti-CCP were the only predictors that determined progression into RA within a year (p < 0.001 and p = 0.02, respectively). Early hand joint involvement and positive anti-CCP at disease onset are good predictors for progression to RA in this domain.
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      dateModified:2014-03-13T00:00:00Z
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      name:Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
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