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  2. Matching Content Categories
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  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
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We are analyzing https://link.springer.com/article/10.1007/s10067-008-0942-9.

Title:
Chilblain lupus erythematosus—a review of literature | Clinical Rheumatology
Description:
Chilblain lupus erythematosus (CHLE) is a rare, chronic form of cutaneous lupus erythematosus. Sporadic cases and two families with autosomal dominant-inherited CHLE have been reported. In familial CHLE, two missense mutations in TREX1 encoding the 3′–5′ repair exonuclease 1 were described in affected individuals. The pathogenesis of sporadic CHLE remains unknown. Up to 20% of patients develop systemic lupus erythematosus (SLE). An association with anorexia is discussed. In many cases, there is good response to symptomatic therapy. SLE therapeutics have good effects on SLE-typical symptoms but not on chilblains themselves. This article reviews the clinical presentation, pathogenesis, diagnosis and treatment of CHLE. As an index patient with unique features, we report a 13-year-old boy developing CHLE after anorexia nervosa. Sequencing of TREX1 was normal. With psychotherapeutic support for anorexia and after antibiotic therapy, topical steroids, physical warming and calcium channel blockers, the patient experienced significant relief. Improvement of phalangeal perfusion was demonstrated by angio-MRI.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Health & Fitness
  • Science

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,794,403 visitors per month in the current month.

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How Does Link.springer.com Make Money? {šŸ’ø}

We're unsure if the website is profiting.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {šŸ”}

lupus, article, google, scholar, erythematosus, pubmed, cas, chilblain, dermatol, trex, chle, systemic, syndrome, clinical, access, university, privacy, cookies, content, hedrich, patients, med, dresden, information, publish, search, rheumatology, review, fiebig, hauck, cutaneous, familial, exonuclease, sle, anorexia, treatment, study, open, dna, antigen, hutchinson, clin, hospital, germany, data, log, journal, research, published, sallmann,

Topics {āœ’ļø}

dominant aicardi–goutieres syndrome antiphospholipid antibody syndrome systemic lupus erythematosus min ae lee-kirsch month download article/chapter t-cell ligand activity aicardi–goutiĆØres syndrome cutaneous lupus erythematosus familial chilblain lupus bollain-y-goytia jj chilblain lupus erythematosus chilblain lupus erythematosus autosomal dominant-inherited chle adult-onset sle ro/ssa antigen expression chronic myelomonocytic leukemia chilblain lupus erythematodes syndrome access full article pdf keratinocyte cell membrane privacy choices/manage cookies 1007/s10067-008-0975-0 rights lupus erythematosus uncommon clinical manifestations phalangeal perfusion endothelial receptor expression anti-ro/ss european economic area scope submit manuscript chronic form calcium channel blockers mayo clinic experience van den maagdenberg c-terminal truncations phorbol 12-myristate 13-acetate familial chle conditions privacy policy technical university dresden ribonucleoproteins ro/ssa sle-typical symptoms boy developing chle check access instant access accepting optional cookies article log symptomatic therapy antibiotic therapy article reviews journal finder publish books a

Questions {ā“}

  • Childhood-Onset Systemic Lupus Erythematosus (cSLE): Is It Really Different Than Adult-Onset SLE?

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:Chilblain lupus erythematosus—a review of literature
         description:Chilblain lupus erythematosus (CHLE) is a rare, chronic form of cutaneous lupus erythematosus. Sporadic cases and two families with autosomal dominant-inherited CHLE have been reported. In familial CHLE, two missense mutations in TREX1 encoding the 3′–5′ repair exonuclease 1 were described in affected individuals. The pathogenesis of sporadic CHLE remains unknown. Up to 20% of patients develop systemic lupus erythematosus (SLE). An association with anorexia is discussed. In many cases, there is good response to symptomatic therapy. SLE therapeutics have good effects on SLE-typical symptoms but not on chilblains themselves. This article reviews the clinical presentation, pathogenesis, diagnosis and treatment of CHLE. As an index patient with unique features, we report a 13-year-old boy developing CHLE after anorexia nervosa. Sequencing of TREX1 was normal. With psychotherapeutic support for anorexia and after antibiotic therapy, topical steroids, physical warming and calcium channel blockers, the patient experienced significant relief. Improvement of phalangeal perfusion was demonstrated by angio-MRI.
         datePublished:2008-06-10T00:00:00Z
         dateModified:2008-06-10T00:00:00Z
         pageStart:949
         pageEnd:954
         sameAs:https://doi.org/10.1007/s10067-008-0942-9
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            Cutaneous lupus erythematosus
            Lupus therapy
            Phalangeal vasoconstriction
            Raynaud’s syndrome
            Rheumatology
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      headline:Chilblain lupus erythematosus—a review of literature
      description:Chilblain lupus erythematosus (CHLE) is a rare, chronic form of cutaneous lupus erythematosus. Sporadic cases and two families with autosomal dominant-inherited CHLE have been reported. In familial CHLE, two missense mutations in TREX1 encoding the 3′–5′ repair exonuclease 1 were described in affected individuals. The pathogenesis of sporadic CHLE remains unknown. Up to 20% of patients develop systemic lupus erythematosus (SLE). An association with anorexia is discussed. In many cases, there is good response to symptomatic therapy. SLE therapeutics have good effects on SLE-typical symptoms but not on chilblains themselves. This article reviews the clinical presentation, pathogenesis, diagnosis and treatment of CHLE. As an index patient with unique features, we report a 13-year-old boy developing CHLE after anorexia nervosa. Sequencing of TREX1 was normal. With psychotherapeutic support for anorexia and after antibiotic therapy, topical steroids, physical warming and calcium channel blockers, the patient experienced significant relief. Improvement of phalangeal perfusion was demonstrated by angio-MRI.
      datePublished:2008-06-10T00:00:00Z
      dateModified:2008-06-10T00:00:00Z
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         Cutaneous lupus erythematosus
         Lupus therapy
         Phalangeal vasoconstriction
         Raynaud’s syndrome
         Rheumatology
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                  address:
                     name:Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
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               name:Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
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            name:University Medical Center Ulm
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               name:Department of Dermatology and Allergology, University Medical Center Ulm, Ulm, Germany
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      affiliation:
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            address:
               name:Children’s Hospital Freital, Freital, Germany
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      affiliation:
            name:University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden
            address:
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      name:Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
      name:Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
      name:Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
      name:Department of Radiology, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
      name:Department of Dermatology and Allergology, University Medical Center Ulm, Ulm, Germany
      name:Children’s Hospital Freital, Freital, Germany
      name:Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Dresden, University Hospital ā€œCarl Gustav Carusā€, Technical University Dresden, Dresden, Germany
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External Links {šŸ”—}(117)

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