We are analyzing https://link.springer.com/article/10.1007/s10059-013-2159-2.

Title:
A competitive peptide inhibitor KIDARI negatively regulates HFR1 by forming nonfunctional heterodimers in Arabidopsis photomorphogenesis | Molecules and Cells
Description:
Dynamic dimer formation is an elaborate means of modulating transcription factor activities in diverse cellular processes. The basic helix-loop-helix (bHLH) transcription factor LONG HYPOCOTYL IN FAR-RED 1 (HFR1), for example, plays a role in plant photomorphogenesis by forming non-DNA binding heterodimers with PHYTOCHROMEINTERACTING FACTORS (PIFs). Recent studies have shown that a small HLH protein KIDARI (KDR) negatively regulates the HFR1 activity in the process. However, molecular mechanisms underlying the KDR control of the HFR1 activity are unknown. Here, we demonstrate that KDR attenuates the HFR1 activity by competitively forming nonfunctional heterodimers, causing liberation of PIF4 from the transcriptionally inactive HFR1-PIF4 complex. Accordingly, the photomorphogenic hypocotyl growth of the HFR1-overexpres-sing plants can be suppressed by KDR coexpression, as observed in the HFR1-deficient hfr1-201 mutant. These results indicate that the PIF4 activity is modulated through a double layer of competitive inhibition by HFR1 and KDR, which could in turn ensure fine-tuning of the PIF4 activity under fluctuating light conditions.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, google, scholar, cas, pubmed, plant, arabidopsis, hfr, light, signaling, cell, transcription, phytochrome, park, factor, biol, seo, factors, dev, fankhauser, competitive, hong, bhlh, binding, protein, kdr, plants, access, kim, privacy, cookies, content, kidari, regulates, heterodimers, hypocotyl, activity, curr, quail, information, publish, research, search, cells, negatively, forming, photomorphogenesis, chungmo, pif, growth,

Topics {✒️}

elf4-elf3-lux complex links month download article/chapter basic helix-loop-helix je-chang woo hfr1-deficient hfr1-201 mutant cross-dimer salt bridges turn ensure fine-tuning carboxy-terminal output module competitive peptide inhibitor apical-basal pattern formation light-regulated nucleocytoplasmic partitioning hfr1-overexpres-sing plants helix-loop-helix chung-mo park light-regulated plant growth cells shin-young hong diurnal light-dark conditions shin-hae cho pistillata negatively regulate full article pdf related subjects zhd5 transcription factor dna binding heterodimers atypical bhlh protein transcription factor essential privacy choices/manage cookies authors contributed equally circadian-clock control negatively regulates photomorphogenic hypocotyl growth blue light receptors pil joon seo molecular mechanisms underlying tryptophan-mediated disruption agrobacterium-mediated transformation siz1-mediated sumoylation cop1 e3 ligase fluctuating light conditions reveals topological small interfering peptides forming nonfunctional heterodimers phytochrome interacting factors phytochrome-interacting factors perceive blue light versatile cell system article molecules conditions privacy policy european economic area diverse cellular processes shade avoidance response

Questions {❓}

Interactions of coiled coils in transcription factors: where is the specificity?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A competitive peptide inhibitor KIDARI negatively regulates HFR1 by forming nonfunctional heterodimers in Arabidopsis photomorphogenesis
         description:Dynamic dimer formation is an elaborate means of modulating transcription factor activities in diverse cellular processes. The basic helix-loop-helix (bHLH) transcription factor LONG HYPOCOTYL IN FAR-RED 1 (HFR1), for example, plays a role in plant photomorphogenesis by forming non-DNA binding heterodimers with PHYTOCHROMEINTERACTING FACTORS (PIFs). Recent studies have shown that a small HLH protein KIDARI (KDR) negatively regulates the HFR1 activity in the process. However, molecular mechanisms underlying the KDR control of the HFR1 activity are unknown. Here, we demonstrate that KDR attenuates the HFR1 activity by competitively forming nonfunctional heterodimers, causing liberation of PIF4 from the transcriptionally inactive HFR1-PIF4 complex. Accordingly, the photomorphogenic hypocotyl growth of the HFR1-overexpres-sing plants can be suppressed by KDR coexpression, as observed in the HFR1-deficient hfr1-201 mutant. These results indicate that the PIF4 activity is modulated through a double layer of competitive inhibition by HFR1 and KDR, which could in turn ensure fine-tuning of the PIF4 activity under fluctuating light conditions.
         datePublished:2012-12-04T00:00:00Z
         dateModified:2012-12-04T00:00:00Z
         pageStart:25
         pageEnd:31
         sameAs:https://doi.org/10.1007/s10059-013-2159-2
         keywords:
             Arabidopsis
            competitive inhibition
            KIDARI (KDR)
            light signaling
            LONG HYPOCOTYL IN FAR-RED 1 (HFR1)
            PHYTOCHROMEINTERACTING FACTOR (PIF)
            Cell Biology
            Biochemistry
            general
            Biomedicine
            Biotechnology
         image:
         isPartOf:
            name:Molecules and Cells
            issn:
               0219-1032
               1016-8478
            volumeNumber:35
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Korean Society for Molecular and Cellular Biology
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Shin-Young Hong
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pil Joon Seo
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Korea
                        type:PostalAddress
                     type:Organization
                     name:Chonbuk National University
                     address:
                        name:Department of Chemistry, Chonbuk National University, Jeonju, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jae Yong Ryu
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shin-Hae Cho
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Je-Chang Woo
               affiliation:
                     name:Mokpo National University
                     address:
                        name:Department of Biological Science, Mokpo National University, Muan, Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Chung-Mo Park
               affiliation:
                     name:Seoul National University
                     address:
                        name:Department of Chemistry, Seoul National University, Seoul, Korea
                        type:PostalAddress
                     type:Organization
                     name:Seoul National University
                     address:
                        name:Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A competitive peptide inhibitor KIDARI negatively regulates HFR1 by forming nonfunctional heterodimers in Arabidopsis photomorphogenesis
      description:Dynamic dimer formation is an elaborate means of modulating transcription factor activities in diverse cellular processes. The basic helix-loop-helix (bHLH) transcription factor LONG HYPOCOTYL IN FAR-RED 1 (HFR1), for example, plays a role in plant photomorphogenesis by forming non-DNA binding heterodimers with PHYTOCHROMEINTERACTING FACTORS (PIFs). Recent studies have shown that a small HLH protein KIDARI (KDR) negatively regulates the HFR1 activity in the process. However, molecular mechanisms underlying the KDR control of the HFR1 activity are unknown. Here, we demonstrate that KDR attenuates the HFR1 activity by competitively forming nonfunctional heterodimers, causing liberation of PIF4 from the transcriptionally inactive HFR1-PIF4 complex. Accordingly, the photomorphogenic hypocotyl growth of the HFR1-overexpres-sing plants can be suppressed by KDR coexpression, as observed in the HFR1-deficient hfr1-201 mutant. These results indicate that the PIF4 activity is modulated through a double layer of competitive inhibition by HFR1 and KDR, which could in turn ensure fine-tuning of the PIF4 activity under fluctuating light conditions.
      datePublished:2012-12-04T00:00:00Z
      dateModified:2012-12-04T00:00:00Z
      pageStart:25
      pageEnd:31
      sameAs:https://doi.org/10.1007/s10059-013-2159-2
      keywords:
          Arabidopsis
         competitive inhibition
         KIDARI (KDR)
         light signaling
         LONG HYPOCOTYL IN FAR-RED 1 (HFR1)
         PHYTOCHROMEINTERACTING FACTOR (PIF)
         Cell Biology
         Biochemistry
         general
         Biomedicine
         Biotechnology
      image:
      isPartOf:
         name:Molecules and Cells
         issn:
            0219-1032
            1016-8478
         volumeNumber:35
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Korean Society for Molecular and Cellular Biology
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Shin-Young Hong
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pil Joon Seo
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
                  name:Chonbuk National University
                  address:
                     name:Department of Chemistry, Chonbuk National University, Jeonju, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jae Yong Ryu
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shin-Hae Cho
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Je-Chang Woo
            affiliation:
                  name:Mokpo National University
                  address:
                     name:Department of Biological Science, Mokpo National University, Muan, Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Chung-Mo Park
            affiliation:
                  name:Seoul National University
                  address:
                     name:Department of Chemistry, Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
                  name:Seoul National University
                  address:
                     name:Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Molecules and Cells
      issn:
         0219-1032
         1016-8478
      volumeNumber:35
Organization:
      name:Korean Society for Molecular and Cellular Biology
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Korea
         type:PostalAddress
      name:Chonbuk National University
      address:
         name:Department of Chemistry, Chonbuk National University, Jeonju, Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Korea
         type:PostalAddress
      name:Mokpo National University
      address:
         name:Department of Biological Science, Mokpo National University, Muan, Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Department of Chemistry, Seoul National University, Seoul, Korea
         type:PostalAddress
      name:Seoul National University
      address:
         name:Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Shin-Young Hong
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Pil Joon Seo
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Korea
               type:PostalAddress
            type:Organization
            name:Chonbuk National University
            address:
               name:Department of Chemistry, Chonbuk National University, Jeonju, Korea
               type:PostalAddress
            type:Organization
      name:Jae Yong Ryu
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Shin-Hae Cho
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Je-Chang Woo
      affiliation:
            name:Mokpo National University
            address:
               name:Department of Biological Science, Mokpo National University, Muan, Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Chung-Mo Park
      affiliation:
            name:Seoul National University
            address:
               name:Department of Chemistry, Seoul National University, Seoul, Korea
               type:PostalAddress
            type:Organization
            name:Seoul National University
            address:
               name:Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Chemistry, Seoul National University, Seoul, Korea
      name:Department of Chemistry, Seoul National University, Seoul, Korea
      name:Department of Chemistry, Chonbuk National University, Jeonju, Korea
      name:Department of Chemistry, Seoul National University, Seoul, Korea
      name:Department of Chemistry, Seoul National University, Seoul, Korea
      name:Department of Biological Science, Mokpo National University, Muan, Korea
      name:Department of Chemistry, Seoul National University, Seoul, Korea
      name:Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(150)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4s.

LINK . SPRINGER . COM {}