We are analyzing https://link.springer.com/article/10.1007/s10059-010-0122-z.

Title:
The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells | Molecules and Cells
Description:
A growing body of evidence indicates that deregulation of stem cell fate determinants is a hallmark of many types of malignancies. The neural stem cell fate determinant TLX plays a pivotal role in neurogenesis in the adult brain by maintaining neural stem cells. Here, we report a tumorigenic role of TLX in brain tumor initiation and progression. Increased TLX expression was observed in a number of glioma cells and glioma stem cells, and correlated with poor survival of patients with gliomas. Ectopic expression of TLX in the U87MG glioma cell line and Ink4a/Arf-deficient mouse astrocytes (Ink4a/Arf-/- astrocytes) induced cell proliferation with a concomitant increase in cyclin D expression, and accelerated foci formation in soft agar and tumor formation in in vivo transplantation assays. Furthermore, overexpression of TLX in Ink4a/Arf-/- astrocytes inhibited cell migration and invasion and promoted neurosphere formation and Nestin expression, which are hallmark characteristics of glioma stem cells, under stem cell culture conditions. Our results indicate that TLX is involved in glioma stem cell genesis and represents a potential therapeutic target for this type of malignancy.
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article, cell, stem, google, scholar, cas, pubmed, cells, cancer, neural, tlx, glioma, kim, park, brain, nature, nat, fate, receptor, tumor, expression, access, nuclear, privacy, cookies, content, research, genesis, jeon, human, biol, korea, information, publish, search, progression, mouse, astrocytes, cyclin, formation, rev, shi, data, log, journal, determinant, tumorigenesis, published, soeda, nam,

Topics {✒️}

month download article/chapter ink4a/arf-deficient mouse astrocytes epithelial stem-cell compartments orphan nuclear receptor neural stem cell neural stem cells nuclear receptor tlx ink4a/arf-independent manner regulates cell numbers p53-deficient mouse astrocytes glial cells glioma stem cells cells hyo-jung park embryonic stem cell stem cell traits cancer stem cells wnt signalling pathways induced cell proliferation ink4a/arf-/- astrocytes sung-hak kim brain cancer stem related subjects full article pdf pten control neural privacy choices/manage cookies glioblastoma formation declines brain tumor initiation stem cells cells article increased tlx expression core regulatory circuit cyclin d1 mouse patched mutants jun-kyum kim glioma cells malignant tumour progression lineage-survival oncogenes conditions privacy policy european economic area potential therapeutic target double-edged sword mice lacking tcf-4 samsung medical center myung-jin park radiation molecular cancer hye-min jeon article molecules accelerated foci formation promoted neurosphere formation check access

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         headline:The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells
         description:A growing body of evidence indicates that deregulation of stem cell fate determinants is a hallmark of many types of malignancies. The neural stem cell fate determinant TLX plays a pivotal role in neurogenesis in the adult brain by maintaining neural stem cells. Here, we report a tumorigenic role of TLX in brain tumor initiation and progression. Increased TLX expression was observed in a number of glioma cells and glioma stem cells, and correlated with poor survival of patients with gliomas. Ectopic expression of TLX in the U87MG glioma cell line and Ink4a/Arf-deficient mouse astrocytes (Ink4a/Arf-/- astrocytes) induced cell proliferation with a concomitant increase in cyclin D expression, and accelerated foci formation in soft agar and tumor formation in in vivo transplantation assays. Furthermore, overexpression of TLX in Ink4a/Arf-/- astrocytes inhibited cell migration and invasion and promoted neurosphere formation and Nestin expression, which are hallmark characteristics of glioma stem cells, under stem cell culture conditions. Our results indicate that TLX is involved in glioma stem cell genesis and represents a potential therapeutic target for this type of malignancy.
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      headline:The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells
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