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Title[redir]:
Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190 562 genetic variations in the human genome | Journal of Human Genetics
Description:
To construct an infrastructure for genome-wide association studies of common diseases or drug sensitivities, we have been systematically exploring common variants by resequencing genomic regions containing genes in DNA from 24 Japanese individuals. We have analyzed a total of 154 Mb, corresponding to approximately 5% of the human genome, and so far have identified 174 269 single-nucleotide polymorphisms and 16 293 insertion/deletion polymorphisms within gene regions, i.e., one polymorphism in 807 bp on average. Our data are freely available via our web site (http://snp.ims.u-tokyo.ac.jp) and will facilitate studies to identify genes associated with susceptibility to common diseases and genes involved in sensitivity to therapeutic drugs.
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nature, article, human, genome, content, genetics, cookies, data, journal, japanese, privacy, analysis, information, snp, genetic, association, common, genes, disease, molecular, advertising, november, discovery, millennium, project, haga, yamada, ohnishi, nakamura, tanaka, studies, diseases, polymorphisms, gene, open, japan, permissions, research, site, optional, media, personal, parties, policy, journals, original, published, genebased, part, identification,
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nature portfolio permissions reprints privacy policy nature advertising social media genome-wide association studies gene-based snp discovery gwas summary data permissions heritability analysis reveal japanese millennium project japan identify disease genes personal data privacy data protection human genome center integrated genome sizing snp discovery team journals search log gene linking strategies explore content similar content european economic area neural progenitor cells soluble starch synthase accepting optional cookies tanakaΒ journal resequencing genomic regions usage analysis molecular genetics manage preferences common diseases data article cite nucleotide diversity article haga 1007/s100380200092 share content human genetics drug sensitivities 24 japanese individuals human genome risk journal publish article host genetics polymorphism molecular medicine
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headline:Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190 562 genetic variations in the human genome
description: To construct an infrastructure for genome-wide association studies of common diseases or drug sensitivities, we have been systematically exploring common variants by resequencing genomic regions containing genes in DNA from 24 Japanese individuals. We have analyzed a total of 154 Mb, corresponding to approximately 5% of the human genome, and so far have identified 174 269 single-nucleotide polymorphisms and 16 293 insertion/deletion polymorphisms within gene regions, i.e., one polymorphism in 807 bp on average. Our data are freely available via our web site (http://snp.ims.u-tokyo.ac.jp) and will facilitate studies to identify genes associated with susceptibility to common diseases and genes involved in sensitivity to therapeutic drugs.
datePublished:2002-11-01T00:00:00Z
dateModified:2002-11-01T00:00:00Z
pageStart:605
pageEnd:610
sameAs:https://doi.org/10.1007/s100380200092
keywords:
Key words Single-nucleotide polymorphism (SNP)
Japanese population
Genetic marker
Association study
Common diseases
Human Genetics
Molecular Medicine
Gene Function
Gene Expression
Gene Therapy
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1435-232X
1434-5161
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author:
name:H. Haga
affiliation:
name:Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. [email protected]
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ScholarlyArticle:
headline:Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190 562 genetic variations in the human genome
description: To construct an infrastructure for genome-wide association studies of common diseases or drug sensitivities, we have been systematically exploring common variants by resequencing genomic regions containing genes in DNA from 24 Japanese individuals. We have analyzed a total of 154 Mb, corresponding to approximately 5% of the human genome, and so far have identified 174 269 single-nucleotide polymorphisms and 16 293 insertion/deletion polymorphisms within gene regions, i.e., one polymorphism in 807 bp on average. Our data are freely available via our web site (http://snp.ims.u-tokyo.ac.jp) and will facilitate studies to identify genes associated with susceptibility to common diseases and genes involved in sensitivity to therapeutic drugs.
datePublished:2002-11-01T00:00:00Z
dateModified:2002-11-01T00:00:00Z
pageStart:605
pageEnd:610
sameAs:https://doi.org/10.1007/s100380200092
keywords:
Key words Single-nucleotide polymorphism (SNP)
Japanese population
Genetic marker
Association study
Common diseases
Human Genetics
Molecular Medicine
Gene Function
Gene Expression
Gene Therapy
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1435-232X
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