We began analyzing https://www.nature.com/articles/jhg2008207, but it redirected us to https://www.nature.com/articles/jhg2008207. The analysis below is for the second page.

Title[redir]:
Mutational analysis of 65 Wilson disease patients in Hong Kong Chinese: Identification of 17 novel mutations and its genetic heterogeneity | Journal of Human Genetics
Description:
Wilson disease (WD), an autosomal recessive disorder of copper transport, is the most common inherited liver disorder in Hong Kong Chinese. This was the first local study to elucidate the molecular basis and establish an effective DNA-based diagnostic protocol. The ATP7B genes of 65 patients were amplified by polymerase chain reaction (PCR) and sequenced. Haplotype analysis was performed using D13S301, D13S314, and D13S316. The p.L770L/p.R778L status in 660 subjects was determined to estimate WD prevalence. Allele age of p.R778L was determined by the smallest homozygosity region between D13S301 and D13S270. We identified 42 different mutations with 17 being novel. p.R778L (17.3%) was the most prevalent. Exons 2, 8, 12, 13, and 16 harbored 70% mutations. Thirty-two haplotypes were associated with WD chromosomes. The estimated prevalence rate was 1 in 5,400. Three out of 660 normal subjects had p.L770L/p.R778L. In the remaining 657 individuals, neither p.L770L nor p.R778L was found. We characterized a Hong Kong Chinese-specific ATP7B mutation spectrum with great genetic diversity. Exons 2, 8, 12, 13, and 16 should be screened first. The perfect linkage disequilibrium suggested that p.R778L and its private polymorphism p.L770L originated from a single ancestor. This East-Asian-specific mutation p.R778L/p.L770L is aged at least 5,500 years.

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

disease, kong, hong, mutations, article, patients, chinese, prl, mutation, google, scholar, cas, atpb, wilson, analysis, china, gene, hum, han, genet, allele, nature, genetic, exons, department, study, haplotypes, hospital, data, microsatellite, pcr, prevalence, pll, wilsons, population, region, lee, common, loudianos, populations, identification, mak, copper, molecular, pubmed, content, published, haplotype, identified, found,

Topics {✒️}

nature portfolio research grants council permissions reprints privacy policy nature advertising social media regional distribution author information authors solutions japan auto-seq g-50 columns east-asian-specific mutation wild-type dna sequence author correspondence ka-ming cheung ka-sing wong chun-cheung fu lik-yuen chan chun-hung ko full size image sui-fan tong yiu-ki chan permissions previously published data informative family data sheung-tat fan jak-yiu lai complete family data ching-lung lai ancient han chinese tai-nin chau east-asian countries east-asian populations wing-lai mak genome search strategies ancient han carrying estonian biobank data privacy han chinese originating yu-lung lau parental data confirmed hong kong chinese systemic copper accumulation urinary copper excretion previously published primers larger sample size large population size atp7b mutant alleles pre-symptomatic wilson

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Mutational analysis of 65 Wilson disease patients in Hong Kong Chinese: Identification of 17 novel mutations and its genetic heterogeneity
         description:Wilson disease (WD), an autosomal recessive disorder of copper transport, is the most common inherited liver disorder in Hong Kong Chinese. This was the first local study to elucidate the molecular basis and establish an effective DNA-based diagnostic protocol. The ATP7B genes of 65 patients were amplified by polymerase chain reaction (PCR) and sequenced. Haplotype analysis was performed using D13S301, D13S314, and D13S316. The p.L770L/p.R778L status in 660 subjects was determined to estimate WD prevalence. Allele age of p.R778L was determined by the smallest homozygosity region between D13S301 and D13S270. We identified 42 different mutations with 17 being novel. p.R778L (17.3%) was the most prevalent. Exons 2, 8, 12, 13, and 16 harbored 70% mutations. Thirty-two haplotypes were associated with WD chromosomes. The estimated prevalence rate was 1 in 5,400. Three out of 660 normal subjects had p.L770L/p.R778L. In the remaining 657 individuals, neither p.L770L nor p.R778L was found. We characterized a Hong Kong Chinese-specific ATP7B mutation spectrum with great genetic diversity. Exons 2, 8, 12, 13, and 16 should be screened first. The perfect linkage disequilibrium suggested that p.R778L and its private polymorphism p.L770L originated from a single ancestor. This East-Asian-specific mutation p.R778L/p.L770L is aged at least 5,500Â years.
         datePublished:2008-01-01T00:00:00Z
         dateModified:2008-01-01T00:00:00Z
         pageStart:55
         pageEnd:63
         sameAs:https://doi.org/10.1007/s10038-007-0218-2
         keywords:
             ATP7B
            p.R778L founder mutation
            Genotype
            Haplotype
            Hong Kong Chinese
            Novel mutation
            Wilson disease
            Human Genetics
            Molecular Medicine
            Gene Function
            Gene Expression
            Gene Therapy
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10038-007-0218-2/MediaObjects/10038_2007_218_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10038-007-0218-2/MediaObjects/10038_2007_218_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10038-007-0218-2/MediaObjects/10038_2007_218_Fig3_HTML.gif
         isPartOf:
            name:Journal of Human Genetics
            issn:
               1435-232X
               1434-5161
            volumeNumber:53
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Japan
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Chloe Miu Mak
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
                     name:Queen Mary Hospital
                     address:
                        name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ching-Wan Lam
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Sidney Tam
               affiliation:
                     name:Queen Mary Hospital
                     address:
                        name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ching-Lung Lai
               affiliation:
                     name:The University of Hong Kong, Queen Mary Hospital
                     address:
                        name:Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lik-Yuen Chan
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sheung-Tat Fan
               affiliation:
                     name:The University of Hong Kong, Queen Mary Hospital
                     address:
                        name:Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yu-Lung Lau
               affiliation:
                     name:The University of Hong Kong, Queen Mary Hospital
                     address:
                        name:Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jak-Yiu Lai
               affiliation:
                     name:Princess Margaret Hospital
                     address:
                        name:Department of Medicine, Princess Margaret Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Patrick Yuen
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Joannie Hui
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chun-Cheung Fu
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ka-Sing Wong
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wing-Lai Mak
               affiliation:
                     name:Tuen Mun Hospital
                     address:
                        name:Department of Pathology, Tuen Mun Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kong Tze
               affiliation:
                     name:Tuen Mun Hospital
                     address:
                        name:Department of Pediatrics, Tuen Mun Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sui-Fan Tong
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Abby Lau
               affiliation:
                     name:The Chinese University of Hong Kong, Prince of Wales Hospital
                     address:
                        name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nancy Leung
               affiliation:
                     name:Alice Ho Miu Ling Nethersole Hospital
                     address:
                        name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Aric Hui
               affiliation:
                     name:Alice Ho Miu Ling Nethersole Hospital
                     address:
                        name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ka-Ming Cheung
               affiliation:
                     name:Caritas Medical Center
                     address:
                        name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chun-Hung Ko
               affiliation:
                     name:Caritas Medical Center
                     address:
                        name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yiu-Ki Chan
               affiliation:
                     name:Caritas Medical Centre
                     address:
                        name:Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Oliver Ma
               affiliation:
                     name:Queen Mary Hospital
                     address:
                        name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tai-Nin Chau
               affiliation:
                     name:United Christian Hospital
                     address:
                        name:Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexander Chiu
               affiliation:
                     name:Queen Mary Hospital
                     address:
                        name:Department of Adult Intensive Care Unit, Queen Mary Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yan-Wo Chan
               affiliation:
                     name:Princess Margaret Hospital
                     address:
                        name:Department of Pathology, Princess Margaret Hospital, Hong Kong, China
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Mutational analysis of 65 Wilson disease patients in Hong Kong Chinese: Identification of 17 novel mutations and its genetic heterogeneity
      description:Wilson disease (WD), an autosomal recessive disorder of copper transport, is the most common inherited liver disorder in Hong Kong Chinese. This was the first local study to elucidate the molecular basis and establish an effective DNA-based diagnostic protocol. The ATP7B genes of 65 patients were amplified by polymerase chain reaction (PCR) and sequenced. Haplotype analysis was performed using D13S301, D13S314, and D13S316. The p.L770L/p.R778L status in 660 subjects was determined to estimate WD prevalence. Allele age of p.R778L was determined by the smallest homozygosity region between D13S301 and D13S270. We identified 42 different mutations with 17 being novel. p.R778L (17.3%) was the most prevalent. Exons 2, 8, 12, 13, and 16 harbored 70% mutations. Thirty-two haplotypes were associated with WD chromosomes. The estimated prevalence rate was 1 in 5,400. Three out of 660 normal subjects had p.L770L/p.R778L. In the remaining 657 individuals, neither p.L770L nor p.R778L was found. We characterized a Hong Kong Chinese-specific ATP7B mutation spectrum with great genetic diversity. Exons 2, 8, 12, 13, and 16 should be screened first. The perfect linkage disequilibrium suggested that p.R778L and its private polymorphism p.L770L originated from a single ancestor. This East-Asian-specific mutation p.R778L/p.L770L is aged at least 5,500Â years.
      datePublished:2008-01-01T00:00:00Z
      dateModified:2008-01-01T00:00:00Z
      pageStart:55
      pageEnd:63
      sameAs:https://doi.org/10.1007/s10038-007-0218-2
      keywords:
          ATP7B
         p.R778L founder mutation
         Genotype
         Haplotype
         Hong Kong Chinese
         Novel mutation
         Wilson disease
         Human Genetics
         Molecular Medicine
         Gene Function
         Gene Expression
         Gene Therapy
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10038-007-0218-2/MediaObjects/10038_2007_218_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10038-007-0218-2/MediaObjects/10038_2007_218_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10038-007-0218-2/MediaObjects/10038_2007_218_Fig3_HTML.gif
      isPartOf:
         name:Journal of Human Genetics
         issn:
            1435-232X
            1434-5161
         volumeNumber:53
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Japan
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Chloe Miu Mak
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
                  name:Queen Mary Hospital
                  address:
                     name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ching-Wan Lam
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Sidney Tam
            affiliation:
                  name:Queen Mary Hospital
                  address:
                     name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ching-Lung Lai
            affiliation:
                  name:The University of Hong Kong, Queen Mary Hospital
                  address:
                     name:Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lik-Yuen Chan
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sheung-Tat Fan
            affiliation:
                  name:The University of Hong Kong, Queen Mary Hospital
                  address:
                     name:Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yu-Lung Lau
            affiliation:
                  name:The University of Hong Kong, Queen Mary Hospital
                  address:
                     name:Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jak-Yiu Lai
            affiliation:
                  name:Princess Margaret Hospital
                  address:
                     name:Department of Medicine, Princess Margaret Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Patrick Yuen
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joannie Hui
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chun-Cheung Fu
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ka-Sing Wong
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wing-Lai Mak
            affiliation:
                  name:Tuen Mun Hospital
                  address:
                     name:Department of Pathology, Tuen Mun Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kong Tze
            affiliation:
                  name:Tuen Mun Hospital
                  address:
                     name:Department of Pediatrics, Tuen Mun Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sui-Fan Tong
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Abby Lau
            affiliation:
                  name:The Chinese University of Hong Kong, Prince of Wales Hospital
                  address:
                     name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nancy Leung
            affiliation:
                  name:Alice Ho Miu Ling Nethersole Hospital
                  address:
                     name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aric Hui
            affiliation:
                  name:Alice Ho Miu Ling Nethersole Hospital
                  address:
                     name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ka-Ming Cheung
            affiliation:
                  name:Caritas Medical Center
                  address:
                     name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chun-Hung Ko
            affiliation:
                  name:Caritas Medical Center
                  address:
                     name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yiu-Ki Chan
            affiliation:
                  name:Caritas Medical Centre
                  address:
                     name:Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Oliver Ma
            affiliation:
                  name:Queen Mary Hospital
                  address:
                     name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tai-Nin Chau
            affiliation:
                  name:United Christian Hospital
                  address:
                     name:Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander Chiu
            affiliation:
                  name:Queen Mary Hospital
                  address:
                     name:Department of Adult Intensive Care Unit, Queen Mary Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan-Wo Chan
            affiliation:
                  name:Princess Margaret Hospital
                  address:
                     name:Department of Pathology, Princess Margaret Hospital, Hong Kong, China
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Human Genetics
      issn:
         1435-232X
         1434-5161
      volumeNumber:53
Organization:
      name:Springer Japan
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:Queen Mary Hospital
      address:
         name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:Queen Mary Hospital
      address:
         name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:The University of Hong Kong, Queen Mary Hospital
      address:
         name:Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:The University of Hong Kong, Queen Mary Hospital
      address:
         name:Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:The University of Hong Kong, Queen Mary Hospital
      address:
         name:Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:Princess Margaret Hospital
      address:
         name:Department of Medicine, Princess Margaret Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:Tuen Mun Hospital
      address:
         name:Department of Pathology, Tuen Mun Hospital, Hong Kong, China
         type:PostalAddress
      name:Tuen Mun Hospital
      address:
         name:Department of Pediatrics, Tuen Mun Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:The Chinese University of Hong Kong, Prince of Wales Hospital
      address:
         name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
         type:PostalAddress
      name:Alice Ho Miu Ling Nethersole Hospital
      address:
         name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
         type:PostalAddress
      name:Alice Ho Miu Ling Nethersole Hospital
      address:
         name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
         type:PostalAddress
      name:Caritas Medical Center
      address:
         name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
         type:PostalAddress
      name:Caritas Medical Center
      address:
         name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
         type:PostalAddress
      name:Caritas Medical Centre
      address:
         name:Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong, China
         type:PostalAddress
      name:Queen Mary Hospital
      address:
         name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:United Christian Hospital
      address:
         name:Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China
         type:PostalAddress
      name:Queen Mary Hospital
      address:
         name:Department of Adult Intensive Care Unit, Queen Mary Hospital, Hong Kong, China
         type:PostalAddress
      name:Princess Margaret Hospital
      address:
         name:Department of Pathology, Princess Margaret Hospital, Hong Kong, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Chloe Miu Mak
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
            name:Queen Mary Hospital
            address:
               name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Ching-Wan Lam
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Sidney Tam
      affiliation:
            name:Queen Mary Hospital
            address:
               name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Ching-Lung Lai
      affiliation:
            name:The University of Hong Kong, Queen Mary Hospital
            address:
               name:Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Lik-Yuen Chan
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Sheung-Tat Fan
      affiliation:
            name:The University of Hong Kong, Queen Mary Hospital
            address:
               name:Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Yu-Lung Lau
      affiliation:
            name:The University of Hong Kong, Queen Mary Hospital
            address:
               name:Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Jak-Yiu Lai
      affiliation:
            name:Princess Margaret Hospital
            address:
               name:Department of Medicine, Princess Margaret Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Patrick Yuen
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Joannie Hui
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Chun-Cheung Fu
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Ka-Sing Wong
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Wing-Lai Mak
      affiliation:
            name:Tuen Mun Hospital
            address:
               name:Department of Pathology, Tuen Mun Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Kong Tze
      affiliation:
            name:Tuen Mun Hospital
            address:
               name:Department of Pediatrics, Tuen Mun Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Sui-Fan Tong
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Abby Lau
      affiliation:
            name:The Chinese University of Hong Kong, Prince of Wales Hospital
            address:
               name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Nancy Leung
      affiliation:
            name:Alice Ho Miu Ling Nethersole Hospital
            address:
               name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Aric Hui
      affiliation:
            name:Alice Ho Miu Ling Nethersole Hospital
            address:
               name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Ka-Ming Cheung
      affiliation:
            name:Caritas Medical Center
            address:
               name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Chun-Hung Ko
      affiliation:
            name:Caritas Medical Center
            address:
               name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Yiu-Ki Chan
      affiliation:
            name:Caritas Medical Centre
            address:
               name:Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Oliver Ma
      affiliation:
            name:Queen Mary Hospital
            address:
               name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Tai-Nin Chau
      affiliation:
            name:United Christian Hospital
            address:
               name:Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Alexander Chiu
      affiliation:
            name:Queen Mary Hospital
            address:
               name:Department of Adult Intensive Care Unit, Queen Mary Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      name:Yan-Wo Chan
      affiliation:
            name:Princess Margaret Hospital
            address:
               name:Department of Pathology, Princess Margaret Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
      name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
      name:Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
      name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
      name:Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
      name:Department of Medicine, Princess Margaret Hospital, Hong Kong, China
      name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:DepartmentÂ ofÂ Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Department of Pathology, Tuen Mun Hospital, Hong Kong, China
      name:Department of Pediatrics, Tuen Mun Hospital, Hong Kong, China
      name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
      name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
      name:Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China
      name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
      name:Department of Pediatrics and Adolescent Medicine, Caritas Medical Center, Hong Kong, China
      name:Department of Medicine and Geriatrics, Caritas Medical Centre, Hong Kong, China
      name:Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, China
      name:Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China
      name:Department of Adult Intensive Care Unit, Queen Mary Hospital, Hong Kong, China
      name:Department of Pathology, Princess Margaret Hospital, Hong Kong, China

External Links {🔗}(370)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
Zoom.js

CDN Services {📦}

Crossref

5.57s.

LINK . SPRINGER . COM {}