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We are analyzing https://link.springer.com/article/10.1007/s10014-010-0016-y.

Title:
High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein | Brain Tumor Pathology
Description:
Isocitrate dehydrogenase 1 (IDH1) mutations are common in grade II–III diffuse gliomas and secondary glioblastomas. The aim of this study is to investigate the staining pattern of mIDH1R132H, an antibody specific to mutant IDH1 protein, in primary brain tumors and non-neoplastic systemic organs. Eight of 13 diffuse astrocytomas, 1 of 6 anaplastic astrocytomas, 9 of 11 oligodendrogliomas, 15 of 22 anaplastic oligodendrogliomas, 6 of 7 oligoastrocytomas, and 5 of 8 anaplastic oligoastrocytomas showed both cytoplasmic and nuclear positivity. Two of 25 atypical meningiomas and 2 of 42 pituitary adenomas were positive for mIDH1R132H. The following non-neoplastic systemic organs showed positivity in the cytoplasm alone: the myocardium, peribronchial glands, interlobular ducts of the salivary gland, gastric fundic gland, columnar epithelia of the large bowel, hepatocytes, centroacinar cells, the intercalated ducts of the pancreas, renal proximal and distal tubules, adrenocortex, ovarian granulosa cells, and the choroid plexus epithelia. It was concluded that the immunopositivity detected in non-neoplastic systemic organs was due to cross-reactivity, because immunohistochemistry with an anti-mitochondrial antibody revealed that the mIDH1R132H staining pattern was identical to that of the mitochondria. Therefore, mIDH1R132H positivity should only be considered to be validated when a cell shows both cytoplasmic and nuclear staining.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
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Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

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Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

article, google, scholar, pubmed, idh, cas, brain, mutations, tumors, isocitrate, dehydrogenase, gliomas, nonneoplastic, antibody, diffuse, cancer, privacy, cookies, content, analysis, systemic, organs, mutant, ikota, nobusawa, acta, neuropathol, publish, research, search, tumor, pathology, profiling, primary, specific, glioblastomas, midhrh, immunohistochemistry, access, mutation, tissue, balss, pathol, data, information, log, journal, highthroughput, immunohistochemical, protein,

Topics {✒️}

high-throughput immunohistochemical profiling high-throughput molecular profiling month download article/chapter hideaki yokoo & yoichi nakazato anti-mitochondrial antibody revealed systematic immunohistochemical profiling parsons dw mutant idh1 protein high-grade gliomas tissue microarray technology full article pdf central nervous system isocitrate dehydrogenase-1 mutations isocitrate dehydrogenase mutations idh1 r132h mutation privacy choices/manage cookies mutant idh1 antibody primary brain tumors neoplastic glial tissue neoplastic systemic organs human pathology monoclonal antibody specific isocitrate dehydrogenase 1 article ikota differentiate diffuse glioma european economic area important prognostic biomarker consensus coding sequences conditions privacy policy related subjects gastric fundic gland ovarian granulosa cells choroid plexus epithelia scientific research human glioblastoma multiforme accepting optional cookies recurring mutations found brain tumors 378 brain tumors integrated genomic analysis article log common adult gliomas author information authors tumor specimens journal finder publish immunohistochemistry article cite check access instant access hayato ikota

Questions {❓}

  • Kloosterhof NK, Bralten LB, Dubbink HJ et al (2010) Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?

Schema {🗺️}

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         headline:High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein
         description:Isocitrate dehydrogenase 1 (IDH1) mutations are common in grade II–III diffuse gliomas and secondary glioblastomas. The aim of this study is to investigate the staining pattern of mIDH1R132H, an antibody specific to mutant IDH1 protein, in primary brain tumors and non-neoplastic systemic organs. Eight of 13 diffuse astrocytomas, 1 of 6 anaplastic astrocytomas, 9 of 11 oligodendrogliomas, 15 of 22 anaplastic oligodendrogliomas, 6 of 7 oligoastrocytomas, and 5 of 8 anaplastic oligoastrocytomas showed both cytoplasmic and nuclear positivity. Two of 25 atypical meningiomas and 2 of 42 pituitary adenomas were positive for mIDH1R132H. The following non-neoplastic systemic organs showed positivity in the cytoplasm alone: the myocardium, peribronchial glands, interlobular ducts of the salivary gland, gastric fundic gland, columnar epithelia of the large bowel, hepatocytes, centroacinar cells, the intercalated ducts of the pancreas, renal proximal and distal tubules, adrenocortex, ovarian granulosa cells, and the choroid plexus epithelia. It was concluded that the immunopositivity detected in non-neoplastic systemic organs was due to cross-reactivity, because immunohistochemistry with an anti-mitochondrial antibody revealed that the mIDH1R132H staining pattern was identical to that of the mitochondria. Therefore, mIDH1R132H positivity should only be considered to be validated when a cell shows both cytoplasmic and nuclear staining.
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         dateModified:2011-01-07T00:00:00Z
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            Tissue microarray
            Neurosurgery
            Neurology
            Pathology
            Oncology
            Cancer Research
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      headline:High-throughput immunohistochemical profiling of primary brain tumors and non-neoplastic systemic organs with a specific antibody against the mutant isocitrate dehydrogenase 1 R132H protein
      description:Isocitrate dehydrogenase 1 (IDH1) mutations are common in grade II–III diffuse gliomas and secondary glioblastomas. The aim of this study is to investigate the staining pattern of mIDH1R132H, an antibody specific to mutant IDH1 protein, in primary brain tumors and non-neoplastic systemic organs. Eight of 13 diffuse astrocytomas, 1 of 6 anaplastic astrocytomas, 9 of 11 oligodendrogliomas, 15 of 22 anaplastic oligodendrogliomas, 6 of 7 oligoastrocytomas, and 5 of 8 anaplastic oligoastrocytomas showed both cytoplasmic and nuclear positivity. Two of 25 atypical meningiomas and 2 of 42 pituitary adenomas were positive for mIDH1R132H. The following non-neoplastic systemic organs showed positivity in the cytoplasm alone: the myocardium, peribronchial glands, interlobular ducts of the salivary gland, gastric fundic gland, columnar epithelia of the large bowel, hepatocytes, centroacinar cells, the intercalated ducts of the pancreas, renal proximal and distal tubules, adrenocortex, ovarian granulosa cells, and the choroid plexus epithelia. It was concluded that the immunopositivity detected in non-neoplastic systemic organs was due to cross-reactivity, because immunohistochemistry with an anti-mitochondrial antibody revealed that the mIDH1R132H staining pattern was identical to that of the mitochondria. Therefore, mIDH1R132H positivity should only be considered to be validated when a cell shows both cytoplasmic and nuclear staining.
      datePublished:2011-01-07T00:00:00Z
      dateModified:2011-01-07T00:00:00Z
      pageStart:107
      pageEnd:114
      sameAs:https://doi.org/10.1007/s10014-010-0016-y
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         Isocitrate dehydrogenase 1
         Brain tumors
         Immunohistochemistry
         Tissue microarray
         Neurosurgery
         Neurology
         Pathology
         Oncology
         Cancer Research
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