We are analyzing https://link.springer.com/article/10.1007/s00795-008-0436-5.

Title:
Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression | Medical Molecular Morphology
Description:
Changes in the expression of E-cadherin have been reported to be important in the tumorigenesis and progression of epithelial ovarian carcinoma. To further examine the mechanisms regulating E-cadherin expression in ovarian tumorigenesis, we investigated the immunohistochemical expression of transcriptional repressors for E-cadherin, such as Snail, Slug, SIP1, and Twist, in the ovarian surface epithelium (OSE) and 95 cases of epithelial ovarian tumors. OSE cells were negative for SIP1 and Slug, whereas weak expression of Snail and Twist was observed in 8 (73%) and 3 (27%) cases, respectively. Of 95 ovarian tumors, the expression of Snail, Slug, SIP1, and Twist increased stepwise in benign, borderline, and malignant tumors. Among them, the expression of Snail showed significantly inverse correlation with that of E-cadherin. Regarding the FIGO stage classification, the expressions of Snail and Twist were significantly increased in advanced cases. The prognosis of ovarian carcinoma patients positive for Snail expression was poorer than that of negative patients. Our results indicate that the expression of E-cadherin transcriptional repressors increased with malignancy in ovarian epithelial neoplasms and that the expression of E-cadherin and its negative regulators is altered during ovarian cancer development and peritoneal dissemination.
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Keywords {🔍}

article, ovarian, google, scholar, expression, pubmed, cas, ecadherin, snail, cancer, carcinoma, twist, epithelial, metastasis, slug, horiuchi, epithelium, access, cell, privacy, cookies, content, repressors, sip, progression, akiko, surface, cells, pathol, publish, search, tumorigenesis, kikuchi, ohira, konishi, transcriptional, cases, tumors, patients, protein, human, transition, res, clin, data, information, log, journal, research, molecular,

Topics {✒️}

e-cadherin induces mesenchymal month download article/chapter tanri shiozawa & ikuo konishi epithelial ovarian cancers epithelial-mesenchymal transition zinc-finger transcription factors e-cadherin transcriptional regulators epithelial ovarian carcinoma ovarian carcinoma cells related subjects epithelial ovarian cancer human breast carcinoma full article pdf ovarian epithelial neoplasms e-cadherin repressors ovarian surface epithelium epithelial ovarian tumors privacy choices/manage cookies hepatocellular carcinoma metastasis ovarian cancer invasiveness gamma-catenin protein expression de herreros ag colorectal carcinoma patients epithelial transition melanoma cells involves advanced gastric cancer muller wj ovarian cancer development tumor cell dormancy smad-interacting protein 1 check access instant access article yoshida european economic area figo stage classification extracellular matrix components nieto ma independent prognostic parameter enhanced peritoneal metastasis shinshu university school twist increased stepwise conditions privacy policy ovarian carcinoma e-cadherin expression transcriptional repressor snail twist overexpression correlates transcriptional repressors metastatic lesions compared lymph node status ovarian cancer

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         description:Changes in the expression of E-cadherin have been reported to be important in the tumorigenesis and progression of epithelial ovarian carcinoma. To further examine the mechanisms regulating E-cadherin expression in ovarian tumorigenesis, we investigated the immunohistochemical expression of transcriptional repressors for E-cadherin, such as Snail, Slug, SIP1, and Twist, in the ovarian surface epithelium (OSE) and 95 cases of epithelial ovarian tumors. OSE cells were negative for SIP1 and Slug, whereas weak expression of Snail and Twist was observed in 8 (73%) and 3 (27%) cases, respectively. Of 95 ovarian tumors, the expression of Snail, Slug, SIP1, and Twist increased stepwise in benign, borderline, and malignant tumors. Among them, the expression of Snail showed significantly inverse correlation with that of E-cadherin. Regarding the FIGO stage classification, the expressions of Snail and Twist were significantly increased in advanced cases. The prognosis of ovarian carcinoma patients positive for Snail expression was poorer than that of negative patients. Our results indicate that the expression of E-cadherin transcriptional repressors increased with malignancy in ovarian epithelial neoplasms and that the expression of E-cadherin and its negative regulators is altered during ovarian cancer development and peritoneal dissemination.
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