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Title:
Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis | Journal of Bone and Mineral Metabolism
Description:
Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK4 group received calcium with menaquinone 4 (MK4) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and undercarboxylated osteocalcin (uc-OC) levels were measured by immunoradiometric assay and enzyme immunoassay, respectively, at baseline and on the 7th and 14th days following the start of the treatment. There were no differences in the baseline data including age, weight, phylloquinone, menaquinone 4, menaquinone 7, OC, and uc-OC levels between the MK4 group and the control group. Administration of MK4 significantly raised the MK4 level from 0.20 ± 0.10 (mean ± SE) pg/ml to 15.09 ± 5.62 pg/ml (P < 0.04), and reduced serum uc-OC levels from 2.80 ± 0.93 ng/ml to 1.76 ± 0.56 ng/ml (P < 0.05) at the end of the study, respectively. No significant changes in these levels were observed in the control group. Serum OC levels were stable during the period in both groups. In this randomized prospective study, the MK4 group shows a reduction in the serum uc-OC level within 2 weeks without any significant change in OC, suggesting that the uc-OC is changed to carboxylated OC. This early effect of MK4 on bone metabolism may be estimated by the measurement of serum uc-OC in elderly osteoporotic women with vertebral fractures.
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Keywords {🔍}
article, women, serum, bone, menaquinone, osteocalcin, osteoporosis, group, ucoc, privacy, cookies, content, journal, vitamin, elderly, levels, osaka, data, information, publish, search, metabolism, undercarboxylated, level, weeks, miki, access, log, research, mineral, early, nakatsuka, naka, received, calcium, control, treatment, discover, medicine, japan, springer, optional, personal, including, parties, policy, change, find, track, reduces,
Topics {✒️}
month download article/chapter serum uc-oc level related subjects elderly osteoporotic women serum intact osteocalcin privacy choices/manage cookies established osteoporosis published undercarboxylated osteocalcin full article pdf osaka city university vitamin k2 mineral metabolism aims serum uc-oc european economic area yasuo tomiyoshi bone mineral density serum oc levels conditions privacy policy serum osteocalcin elderly women mk4 significantly raised postmenopausal women uc-oc levels mk4 group shows accepting optional cookies established osteoporosis journal finder publish check access instant access main content log randomized prospective study article journal article miki vitamin mk-7 mk4 level article log kiyoshi nakatsuka hiroshi naka personal data article cite privacy policy uc-oc control group affiliations department graduate school books a osteoporosis mk4 group optional cookies bone metabolism
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headline:Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis
description: Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK4 group received calcium with menaquinone 4 (MK4) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and undercarboxylated osteocalcin (uc-OC) levels were measured by immunoradiometric assay and enzyme immunoassay, respectively, at baseline and on the 7th and 14th days following the start of the treatment. There were no differences in the baseline data including age, weight, phylloquinone, menaquinone 4, menaquinone 7, OC, and uc-OC levels between the MK4 group and the control group. Administration of MK4 significantly raised the MK4 level from 0.20 ± 0.10 (mean ± SE) pg/ml to 15.09 ± 5.62 pg/ml (P < 0.04), and reduced serum uc-OC levels from 2.80 ± 0.93 ng/ml to 1.76 ± 0.56 ng/ml (P < 0.05) at the end of the study, respectively. No significant changes in these levels were observed in the control group. Serum OC levels were stable during the period in both groups. In this randomized prospective study, the MK4 group shows a reduction in the serum uc-OC level within 2 weeks without any significant change in OC, suggesting that the uc-OC is changed to carboxylated OC. This early effect of MK4 on bone metabolism may be estimated by the measurement of serum uc-OC in elderly osteoporotic women with vertebral fractures.
datePublished:
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Key words elderly women
vitamin K2
menaquinone 4
osteoporosis
undercarboxylated osteocalcin
Metabolic Diseases
Orthopedics
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headline:Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis
description: Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK4 group received calcium with menaquinone 4 (MK4) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and undercarboxylated osteocalcin (uc-OC) levels were measured by immunoradiometric assay and enzyme immunoassay, respectively, at baseline and on the 7th and 14th days following the start of the treatment. There were no differences in the baseline data including age, weight, phylloquinone, menaquinone 4, menaquinone 7, OC, and uc-OC levels between the MK4 group and the control group. Administration of MK4 significantly raised the MK4 level from 0.20 ± 0.10 (mean ± SE) pg/ml to 15.09 ± 5.62 pg/ml (P < 0.04), and reduced serum uc-OC levels from 2.80 ± 0.93 ng/ml to 1.76 ± 0.56 ng/ml (P < 0.05) at the end of the study, respectively. No significant changes in these levels were observed in the control group. Serum OC levels were stable during the period in both groups. In this randomized prospective study, the MK4 group shows a reduction in the serum uc-OC level within 2 weeks without any significant change in OC, suggesting that the uc-OC is changed to carboxylated OC. This early effect of MK4 on bone metabolism may be estimated by the measurement of serum uc-OC in elderly osteoporotic women with vertebral fractures.
datePublished:
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pageStart:161
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sameAs:https://doi.org/10.1007/s007740300025
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Key words elderly women
vitamin K2
menaquinone 4
osteoporosis
undercarboxylated osteocalcin
Metabolic Diseases
Orthopedics
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