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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s007740300025.

Title:
Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis | Journal of Bone and Mineral Metabolism
Description:
 Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK4 group received calcium with menaquinone 4 (MK4) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and undercarboxylated osteocalcin (uc-OC) levels were measured by immunoradiometric assay and enzyme immunoassay, respectively, at baseline and on the 7th and 14th days following the start of the treatment. There were no differences in the baseline data including age, weight, phylloquinone, menaquinone 4, menaquinone 7, OC, and uc-OC levels between the MK4 group and the control group. Administration of MK4 significantly raised the MK4 level from 0.20 ± 0.10 (mean ± SE) pg/ml to 15.09 ± 5.62 pg/ml (P < 0.04), and reduced serum uc-OC levels from 2.80 ± 0.93 ng/ml to 1.76 ± 0.56 ng/ml (P < 0.05) at the end of the study, respectively. No significant changes in these levels were observed in the control group. Serum OC levels were stable during the period in both groups. In this randomized prospective study, the MK4 group shows a reduction in the serum uc-OC level within 2 weeks without any significant change in OC, suggesting that the uc-OC is changed to carboxylated OC. This early effect of MK4 on bone metabolism may be estimated by the measurement of serum uc-OC in elderly osteoporotic women with vertebral fractures.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Social Networks
  • Fitness & Wellness
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

article, women, serum, bone, menaquinone, osteocalcin, osteoporosis, group, ucoc, privacy, cookies, content, journal, vitamin, elderly, levels, osaka, data, information, publish, search, metabolism, undercarboxylated, level, weeks, miki, access, log, research, mineral, early, nakatsuka, naka, received, calcium, control, treatment, discover, medicine, japan, springer, optional, personal, including, parties, policy, change, find, track, reduces,

Topics {✒️}

month download article/chapter serum uc-oc level related subjects elderly osteoporotic women serum intact osteocalcin privacy choices/manage cookies established osteoporosis published undercarboxylated osteocalcin full article pdf osaka city university vitamin k2 mineral metabolism aims serum uc-oc european economic area yasuo tomiyoshi bone mineral density serum oc levels conditions privacy policy serum osteocalcin elderly women mk4 significantly raised postmenopausal women uc-oc levels mk4 group shows accepting optional cookies established osteoporosis journal finder publish check access instant access main content log randomized prospective study article journal article miki vitamin mk-7 mk4 level article log kiyoshi nakatsuka hiroshi naka personal data article cite privacy policy uc-oc control group affiliations  department graduate school books a osteoporosis mk4 group optional cookies bone metabolism

Schema {🗺️}

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         headline:Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis
         description: Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK4 group received calcium with menaquinone 4 (MK4) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and undercarboxylated osteocalcin (uc-OC) levels were measured by immunoradiometric assay and enzyme immunoassay, respectively, at baseline and on the 7th and 14th days following the start of the treatment. There were no differences in the baseline data including age, weight, phylloquinone, menaquinone 4, menaquinone 7, OC, and uc-OC levels between the MK4 group and the control group. Administration of MK4 significantly raised the MK4 level from 0.20 ± 0.10 (mean ± SE) pg/ml to 15.09 ± 5.62 pg/ml (P < 0.04), and reduced serum uc-OC levels from 2.80 ± 0.93 ng/ml to 1.76 ± 0.56 ng/ml (P < 0.05) at the end of the study, respectively. No significant changes in these levels were observed in the control group. Serum OC levels were stable during the period in both groups. In this randomized prospective study, the MK4 group shows a reduction in the serum uc-OC level within 2 weeks without any significant change in OC, suggesting that the uc-OC is changed to carboxylated OC. This early effect of MK4 on bone metabolism may be estimated by the measurement of serum uc-OC in elderly osteoporotic women with vertebral fractures.
         datePublished:
         dateModified:
         pageStart:161
         pageEnd:165
         sameAs:https://doi.org/10.1007/s007740300025
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            Key words elderly women
            vitamin K2
            menaquinone 4
            osteoporosis
            undercarboxylated osteocalcin
            Metabolic Diseases
            Orthopedics
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               name:Takami Miki
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                     name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
                     address:
                        name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
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                     name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
                     address:
                        name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
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                     name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
                     address:
                        name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
                        type:PostalAddress
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                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
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                        name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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                        name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
                        type:PostalAddress
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               name:Hideki Masaki
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                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                     address:
                        name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
                        type:PostalAddress
                     type:Organization
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               name:Yasuo Tomiyoshi
               affiliation:
                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                     address:
                        name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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                     name: Aino Gakuen College, Ibaragi, Osaka, Japan
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                        name: Aino Gakuen College, Ibaragi, Osaka, Japan, , JP
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               name:Yoshiki Nishizawa
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                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
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                        name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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      headline:Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis
      description: Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK4 group received calcium with menaquinone 4 (MK4) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and undercarboxylated osteocalcin (uc-OC) levels were measured by immunoradiometric assay and enzyme immunoassay, respectively, at baseline and on the 7th and 14th days following the start of the treatment. There were no differences in the baseline data including age, weight, phylloquinone, menaquinone 4, menaquinone 7, OC, and uc-OC levels between the MK4 group and the control group. Administration of MK4 significantly raised the MK4 level from 0.20 ± 0.10 (mean ± SE) pg/ml to 15.09 ± 5.62 pg/ml (P < 0.04), and reduced serum uc-OC levels from 2.80 ± 0.93 ng/ml to 1.76 ± 0.56 ng/ml (P < 0.05) at the end of the study, respectively. No significant changes in these levels were observed in the control group. Serum OC levels were stable during the period in both groups. In this randomized prospective study, the MK4 group shows a reduction in the serum uc-OC level within 2 weeks without any significant change in OC, suggesting that the uc-OC is changed to carboxylated OC. This early effect of MK4 on bone metabolism may be estimated by the measurement of serum uc-OC in elderly osteoporotic women with vertebral fractures.
      datePublished:
      dateModified:
      pageStart:161
      pageEnd:165
      sameAs:https://doi.org/10.1007/s007740300025
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         Key words elderly women
         vitamin K2
         menaquinone 4
         osteoporosis
         undercarboxylated osteocalcin
         Metabolic Diseases
         Orthopedics
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      isPartOf:
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         name:Springer-Verlag
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      author:
            name:Takami Miki
            affiliation:
                  name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
                  address:
                     name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
                     type:PostalAddress
                  type:Organization
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            name:Kiyoshi Nakatsuka
            affiliation:
                  name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
                  address:
                     name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
                     type:PostalAddress
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            name:Hiroshi Naka
            affiliation:
                  name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
                  address:
                     name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kayoko Kitatani
            affiliation:
                  name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                  address:
                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shinichi Saito
            affiliation:
                  name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                  address:
                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hideki Masaki
            affiliation:
                  name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                  address:
                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yasuo Tomiyoshi
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                  name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                  address:
                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hirotoshi Morii
            affiliation:
                  name: Aino Gakuen College, Ibaragi, Osaka, Japan
                  address:
                     name: Aino Gakuen College, Ibaragi, Osaka, Japan, , JP
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoshiki Nishizawa
            affiliation:
                  name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
                  address:
                     name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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      name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
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      name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
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         name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
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      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
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         name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
      address:
         name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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         name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
      address:
         name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
         type:PostalAddress
      name: Aino Gakuen College, Ibaragi, Osaka, Japan
      address:
         name: Aino Gakuen College, Ibaragi, Osaka, Japan, , JP
         type:PostalAddress
      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
      address:
         name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
         type:PostalAddress
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Person:
      name:Takami Miki
      affiliation:
            name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
            address:
               name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Kiyoshi Nakatsuka
      affiliation:
            name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
            address:
               name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Hiroshi Naka
      affiliation:
            name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
            address:
               name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Kayoko Kitatani
      affiliation:
            name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
            address:
               name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Shinichi Saito
      affiliation:
            name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
            address:
               name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Hideki Masaki
      affiliation:
            name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
            address:
               name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Yasuo Tomiyoshi
      affiliation:
            name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
            address:
               name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Hirotoshi Morii
      affiliation:
            name: Aino Gakuen College, Ibaragi, Osaka, Japan
            address:
               name: Aino Gakuen College, Ibaragi, Osaka, Japan, , JP
               type:PostalAddress
            type:Organization
      name:Yoshiki Nishizawa
      affiliation:
            name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
            address:
               name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
               type:PostalAddress
            type:Organization
PostalAddress:
      name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
      name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
      name: Department of Geriatric Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan, , JP
      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
      name: Aino Gakuen College, Ibaragi, Osaka, Japan, , JP
      name: Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan, , JP
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External Links {🔗}(40)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

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