We are analyzing https://link.springer.com/article/10.1007/s00709-016-1063-y.

Title:
Genomic effects of glucocorticoids | Protoplasma
Description:
Glucocorticoids and their receptor (GR) have been an important area of research because of their pleiotropic physiological functions and extensive use in the clinic. In addition, the association between GR and glucocorticoids, which is highly specific, leads to rapid nuclear translocation where GR associates with chromatin to regulate gene transcription. This simplified model system has been instrumental for studying the complexity of transcription regulation processes occurring at chromatin. In this review we discuss our current understanding of GR action that has been enhanced by recent developments in genome wide measurements of chromatin accessibility, histone marks, chromatin remodeling and 3D chromatin structure in various cell types responding to glucocorticoids.
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Keywords {🔍}

pubmed, article, google, scholar, cas, glucocorticoid, receptor, central, chromatin, cell, transcription, binding, glucocorticoids, gene, regulation, genome, mol, nat, response, nature, factors, john, interactions, res, analysis, genomic, accessibility, genet, rev, biol, effects, sites, doi, steroid, dna, doijcell, remodeling, structure, receptors, elements, factor, transcriptional, hager, genes, doigr, human, privacy, cookies, site, function,

Topics {✒️}

long-range chromatin interactions month download article/chapter long-range interaction landscape α-globin super-enhancer glucocorticoid-dependent enhancer element direct/indirect dna recruitment long range interactions long-range interactions transcription factor interactions steroid hormone receptors agonist-liganded glucocorticoid receptor camp-induced crh gene nuclear factor kappa stat3/gr interaction code ligand-induced repression steroid-inducible mmtv promoter pioneer transcription factors article protoplasma aims regulate gene transcription full article pdf cooperating transcription factors multiple transcription factors zaret ks israel science foundation related subjects latent enhancers activated article grbesa chromatin remodeling complexes chip-sequencing dbd plasma adrenocorticotropic hormone rapid nuclear translocation uhlenhaut nh glucocorticoid receptor binding chip-exo signal molecular genetic analysis glucocorticoid receptor gene glucocorticoid response element glucocorticoid-mediated apoptosis privacy choices/manage cookies steroid response elements single dna element glucocorticoid receptor control glucocorticoid receptor action alternate promoter states human glucocorticoid receptor ofir hakim rheum dis clin sequence-specific positioning glucocorticoid receptor activation 3d chromatin structure

Questions {❓}

Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses?

Schema {🗺️}

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