We are analyzing https://link.springer.com/article/10.1007/s00705-009-0527-1.

Title:
The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection | Archives of Virology
Description:
The porcine reproductive and respiratory syndrome virus (PRRSV) enters its target cell via clathrin-mediated endocytosis. Using dominant-negative Rab5 and Rab7 mutants, we show that upon internalization, PRRSV enters early endosomes but does not continue through the endocytic pathway to late endosomes. This was confirmed via colocalization experiments visualizing PRRSV and markers for different compartments of the endocytic pathway. Furthermore, it was shown that PRRSV colocalizes with its internalization receptor, sialoadhesin, on the cell surface and beneath the plasma membrane, while CD163 and PRRSV only meet in early endosomes.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter macrophage-specific receptor sialoadhesin n-terminal immunoglobulin domain cd163-positive early endosomes sialic acid-binding activity small envelope protein full article pdf endocytic pathway privacy choices/manage cookies productive infection receptor-mediated endocytosis respiratory syndrome virus clathrin-mediated endocytosis porcine arterivirus infection primary macrophages respiratory syndrome viruses cd163 join forces dominant-negative rab5 mouth disease virus van woensel pa porcine alveolar macrophages european economic area trans-golgi network protective transcriptional response excellent technical assistance conditions privacy policy wander van breedam article archives early endosomes prrsv allowing evasion check access instant access accepting optional cookies main content log matrix protein late endosomes journal finder publish porcine arterivirus attachment author information authors cell biol 131 article log plasma membrane early events membrane organizers ghent university alveolar macrophages delputte pl virology article article cite constitutive endocytosis

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         datePublished:2009-11-03T00:00:00Z
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      description:The porcine reproductive and respiratory syndrome virus (PRRSV) enters its target cell via clathrin-mediated endocytosis. Using dominant-negative Rab5 and Rab7 mutants, we show that upon internalization, PRRSV enters early endosomes but does not continue through the endocytic pathway to late endosomes. This was confirmed via colocalization experiments visualizing PRRSV and markers for different compartments of the endocytic pathway. Furthermore, it was shown that PRRSV colocalizes with its internalization receptor, sialoadhesin, on the cell surface and beneath the plasma membrane, while CD163 and PRRSV only meet in early endosomes.
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