We are analyzing https://link.springer.com/article/10.1007/s00705-006-0821-0.

Title:
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins | Archives of Virology
Description:
The regulation of host-mediated apoptosis by the E6 and E7 oncoproteins has garnered attention because it is believed to be an important strategy employed by high-risk (HR)-human papillomaviruses (HPVs) to evade immune surveillance. Additionally, the revelation that E5 can protect cells from tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis suggests that it may also play a role in undermining host defense mechanisms. Cellular transformation is an unintended consequence of persistent infection by HR-HPVs, and it is therefore likely that the primary function of E5, E6 and E7 is to regulate cell survival throughout the normal viral life cycle in order to ensure viral replication and promote the spread of progeny. The purpose of this article is to review the literature on the regulation of host-mediated apoptosis by E5, E6 and E7 that describes the mechanisms employed by HR-HPVs to persist in the host and create the conditions necessary for cellular transformation.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Politics
Law & Government

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 8,170,236 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

cas, google, scholar, pubmed, article, human, papillomavirus, type, protein, apoptosis, hpv, oncogene, virol, oncoprotein, cell, cells, cancer, proteins, sjonc, banks, oncoproteins, biol, jvi, cervical, virus, gene, activity, factor, duerksenhughes, tumor, chem, science, van, regulation, highrisk, papilloma, chen, howley, binds, death, degradation, lee, usa, transformation, access, interaction, mol, res, keratinocytes, expression,

Topics {✒️}

kenter cj melief cervical intraepithelial neoplasia month download article/chapter dimaio es hwang parkhurst pj duerksen-hughes nakagawa jm huibregtse tumor necrosis factor johnson cm simbulan-rosenthal ifn-alpha-induced apoptosis nader dj mccance 16-kilodalton pore-forming protein hong jj chen duerksen-hughes pj inactivates growth-inhibitory insulin human virus oncoproteins scheffner pm howley hubert sl giannini schlegel dj mccance stromal macrophage/dendrocyte populations life cycle dc%2bd3sxitl2ksg%3d%3d 10 dc%2bd3mxhsfckuw%3d%3d 10 dc%2bd2cxhsfomsq%3d%3d 10 van deurs duerksen-hughes rights epithelial cell line stoppler mc stoppler hpv-tumor diagnosis high-risk papillomaviruses bind mannhardt sa weinzimer specific protein recognition pdz ligand domain ubiquitin-mediated degradation human papillomavirus immortalization interferon regulatory factor-3 krishna ej androphy papillomavirus e6 oncoproteins dyson pm howley vidal pm howley tong pm howley full article pdf intraepithelial langerhans’ cells type 16 virus brien ms campo transcriptional coactivator cbp/p300 ensure viral replication squamous intraepithelial lesions pitot pf lambert e7 oncoprotein associates tata-binding protein

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Modulation of apoptosis by human papillomavirus (HPV) oncoproteins
         description:The regulation of host-mediated apoptosis by the E6 and E7 oncoproteins has garnered attention because it is believed to be an important strategy employed by high-risk (HR)-human papillomaviruses (HPVs) to evade immune surveillance. Additionally, the revelation that E5 can protect cells from tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis suggests that it may also play a role in undermining host defense mechanisms. Cellular transformation is an unintended consequence of persistent infection by HR-HPVs, and it is therefore likely that the primary function of E5, E6 and E7 is to regulate cell survival throughout the normal viral life cycle in order to ensure viral replication and promote the spread of progeny. The purpose of this article is to review the literature on the regulation of host-mediated apoptosis by E5, E6 and E7 that describes the mechanisms employed by HR-HPVs to persist in the host and create the conditions necessary for cellular transformation.
         datePublished:2006-07-27T00:00:00Z
         dateModified:2006-07-27T00:00:00Z
         pageStart:2321
         pageEnd:2335
         sameAs:https://doi.org/10.1007/s00705-006-0821-0
         keywords:
            Human Papilloma Virus
            Cervical Intraepithelial Neoplasia
            Disc Large Tumor Suppressor Protein
            Normal Viral Life Cycle
            Virology
            Medical Microbiology
            Infectious Diseases
         image:
         isPartOf:
            name:Archives of Virology
            issn:
               1432-8798
               0304-8608
            volumeNumber:151
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:T. O. Garnett
               affiliation:
                     name:Loma Linda University School of Medicine
                     address:
                        name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
                        type:PostalAddress
                     type:Organization
               type:Person
               name:P. J. Duerksen-Hughes
               affiliation:
                     name:Loma Linda University School of Medicine
                     address:
                        name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Modulation of apoptosis by human papillomavirus (HPV) oncoproteins
      description:The regulation of host-mediated apoptosis by the E6 and E7 oncoproteins has garnered attention because it is believed to be an important strategy employed by high-risk (HR)-human papillomaviruses (HPVs) to evade immune surveillance. Additionally, the revelation that E5 can protect cells from tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis suggests that it may also play a role in undermining host defense mechanisms. Cellular transformation is an unintended consequence of persistent infection by HR-HPVs, and it is therefore likely that the primary function of E5, E6 and E7 is to regulate cell survival throughout the normal viral life cycle in order to ensure viral replication and promote the spread of progeny. The purpose of this article is to review the literature on the regulation of host-mediated apoptosis by E5, E6 and E7 that describes the mechanisms employed by HR-HPVs to persist in the host and create the conditions necessary for cellular transformation.
      datePublished:2006-07-27T00:00:00Z
      dateModified:2006-07-27T00:00:00Z
      pageStart:2321
      pageEnd:2335
      sameAs:https://doi.org/10.1007/s00705-006-0821-0
      keywords:
         Human Papilloma Virus
         Cervical Intraepithelial Neoplasia
         Disc Large Tumor Suppressor Protein
         Normal Viral Life Cycle
         Virology
         Medical Microbiology
         Infectious Diseases
      image:
      isPartOf:
         name:Archives of Virology
         issn:
            1432-8798
            0304-8608
         volumeNumber:151
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:T. O. Garnett
            affiliation:
                  name:Loma Linda University School of Medicine
                  address:
                     name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. J. Duerksen-Hughes
            affiliation:
                  name:Loma Linda University School of Medicine
                  address:
                     name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Archives of Virology
      issn:
         1432-8798
         0304-8608
      volumeNumber:151
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Loma Linda University School of Medicine
      address:
         name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
         type:PostalAddress
      name:Loma Linda University School of Medicine
      address:
         name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:T. O. Garnett
      affiliation:
            name:Loma Linda University School of Medicine
            address:
               name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
               type:PostalAddress
            type:Organization
      name:P. J. Duerksen-Hughes
      affiliation:
            name:Loma Linda University School of Medicine
            address:
               name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
      name:Department of Biochemistry and Microbiology, Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Loma Linda, U.S.A.
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(290)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.95s.

LINK . SPRINGER . COM {}