We are analyzing https://link.springer.com/article/10.1007/s00702-002-0808-2.

Title:
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen | Journal of Neural Transmission
Description:
Journal of Neural Transmission - The progressive, neurodegenerative process underlying idiopathic Parkinson
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Keywords {🔍}

article, disease, parkinsons, idiopathic, nervous, system, access, privacy, cookies, content, journal, vulnerable, information, publish, search, pathogen, braak, vagus, data, log, research, neural, neuronal, types, rüb, gai, brain, motor, nerve, subcortical, discover, university, springer, optional, personal, parties, policy, find, track, transmission, routes, subject, neuroinvasion, unknown, published, cite, del, tredici, explore, process,

Topics {✒️}

month download article/chapter proteinaceous inclusion bodies retrograde axonal related subjects enteric nervous system central nervous system lower brain stem privacy choices/manage cookies vulnerable brain regions human nervous system full article pdf neural transmission aims vulnerable neuronal types vulnerable subcortical grays european economic area scope submit manuscript postganglionic enteric neurons visceromotor projection cells hypothesized mechanism offers apparently uninterrupted manner bundesministerium für bildung forschung und technologie skillful technical assistance conditions privacy policy dorsal motor nucleus susceptible neuronal types transneuronal transport accepting optional cookies d-60590 frankfurt/main journal finder publish unknown pathogen published article journal basal forebrain idiopathic parkinson' article log disease intestine gain access check access 1007/s00702-002-0808-2 keywords instant access subcortical grays privacy policy personal data article cite process begins de rights books a article braak neural transm 110 optional cookies

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         headline:Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
         description: The progressive, neurodegenerative process underlying idiopathic Parkinson's disease is associated with the formation of proteinaceous inclusion bodies that involve a few susceptible neuronal types of the human nervous system. In the lower brain stem, the process begins in the dorsal motor nucleus of the vagus nerve and advances from there essentially upwards through susceptible regions of the medulla oblongata, pontine tegmentum, midbrain, and basal forebrain until it reaches the cerebral cortex. With time, multiple components of the autonomic, limbic, and motor systems become severely impaired. All of the vulnerable subcortical grays and cortical areas are closely interconnected. Incidental cases of idiopathic Parkinson's disease may show involvement of both the enteric nervous system and the dorsal motor nucleus of the vagus nerve. This observation, combined with the working hypothesis that the stereotypic topographic expansion pattern of the lesions may resemble that of a falling row of dominos, prompts the question whether the disorder might originate outside of the central nervous system, caused by a yet unidentified pathogen that is capable of passing the mucosal barrier of the gastrointestinal tract and, via postganglionic enteric neurons, entering the central nervous system along unmyelinated praeganglionic fibers generated from the visceromotor projection cells of the vagus nerve. By way of retrograde axonal and transneuronal transport, such a causative pathogen could reach selectively vulnerable subcortical nuclei and, unimpeded, gain access to the cerebral cortex. The here hypothesized mechanism offers one possible explanation for the sequential and apparently uninterrupted manner in which vulnerable brain regions, subcortical grays and cortical areas become involved in idiopathic Parkinson's disease.
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            neurotropic pathogens
            retrograde axonal transport
            neuropathological staging.
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            Psychiatry
            Neurosciences
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      headline:Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
      description: The progressive, neurodegenerative process underlying idiopathic Parkinson's disease is associated with the formation of proteinaceous inclusion bodies that involve a few susceptible neuronal types of the human nervous system. In the lower brain stem, the process begins in the dorsal motor nucleus of the vagus nerve and advances from there essentially upwards through susceptible regions of the medulla oblongata, pontine tegmentum, midbrain, and basal forebrain until it reaches the cerebral cortex. With time, multiple components of the autonomic, limbic, and motor systems become severely impaired. All of the vulnerable subcortical grays and cortical areas are closely interconnected. Incidental cases of idiopathic Parkinson's disease may show involvement of both the enteric nervous system and the dorsal motor nucleus of the vagus nerve. This observation, combined with the working hypothesis that the stereotypic topographic expansion pattern of the lesions may resemble that of a falling row of dominos, prompts the question whether the disorder might originate outside of the central nervous system, caused by a yet unidentified pathogen that is capable of passing the mucosal barrier of the gastrointestinal tract and, via postganglionic enteric neurons, entering the central nervous system along unmyelinated praeganglionic fibers generated from the visceromotor projection cells of the vagus nerve. By way of retrograde axonal and transneuronal transport, such a causative pathogen could reach selectively vulnerable subcortical nuclei and, unimpeded, gain access to the cerebral cortex. The here hypothesized mechanism offers one possible explanation for the sequential and apparently uninterrupted manner in which vulnerable brain regions, subcortical grays and cortical areas become involved in idiopathic Parkinson's disease.
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      dateModified:
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      pageEnd:536
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         Lewy neurites/bodies
         neurotropic pathogens
         retrograde axonal transport
         neuropathological staging.
         Neurology
         Psychiatry
         Neurosciences
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