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         headline:Pamidronate treatment in patients with malignant osteolytic bone disease and pain
         description: The aim of this double-blind, randomized study was to compare the effects of two pamidronate dosages, given as repeated infusions in patients with advanced malignant osteolytic bone disease and bone pain. Seventy patients were randomly assigned to receive pamidronate 60 mg or 90 mg i.v. every 3 weeks for a maximum of six cycles. Pain parameters, analgesic consumption and performance status were assessed at baseline and throughout the study. Furthermore, total-body bone mineral density was measured using dual- energy X-ray absorptiometry at baseline, after three and after six infusions. Sixty percent (95% CI 41–77%) of the patients in the 60 mg group and 63% (95% CI 44–79%) of the patients in the 90-mg group had a sustained reduction of pain intensity and were classified as pain responders. Median duration of pain response was 15 versus 12 weeks in the 60-mg and 90-mg groups, respectively (P=0.32). After two infusions, significant changes in pain intensity, pain frequency, general well-being and WHO pain score were observed (P<0.01). A trend toward improved performance status and reduced consumption of analgesics was also observed. Patients in the 90-mg group had more pronounced bone remineralization as measured by total-body bone mineral density. No significant difference was detectable between the two pamidronate treatments in any of the parameters evaluated. In conclusion, bone pain can be effectively reduced by repeated pami-dronate infusions in patients with advanced osteolytic bone disease. Pamidronate 90 mg every 3 weeks results in higher bone remineralization, but this difference did not translate into a further increase of palliative effects.
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            Key words Pamidronate
            Osteolytic bone disease
            Oncology
            Nursing
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            Rehabilitation Medicine
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                        name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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                        name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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      headline:Pamidronate treatment in patients with malignant osteolytic bone disease and pain
      description: The aim of this double-blind, randomized study was to compare the effects of two pamidronate dosages, given as repeated infusions in patients with advanced malignant osteolytic bone disease and bone pain. Seventy patients were randomly assigned to receive pamidronate 60 mg or 90 mg i.v. every 3 weeks for a maximum of six cycles. Pain parameters, analgesic consumption and performance status were assessed at baseline and throughout the study. Furthermore, total-body bone mineral density was measured using dual- energy X-ray absorptiometry at baseline, after three and after six infusions. Sixty percent (95% CI 41–77%) of the patients in the 60 mg group and 63% (95% CI 44–79%) of the patients in the 90-mg group had a sustained reduction of pain intensity and were classified as pain responders. Median duration of pain response was 15 versus 12 weeks in the 60-mg and 90-mg groups, respectively (P=0.32). After two infusions, significant changes in pain intensity, pain frequency, general well-being and WHO pain score were observed (P<0.01). A trend toward improved performance status and reduced consumption of analgesics was also observed. Patients in the 90-mg group had more pronounced bone remineralization as measured by total-body bone mineral density. No significant difference was detectable between the two pamidronate treatments in any of the parameters evaluated. In conclusion, bone pain can be effectively reduced by repeated pami-dronate infusions in patients with advanced osteolytic bone disease. Pamidronate 90 mg every 3 weeks results in higher bone remineralization, but this difference did not translate into a further increase of palliative effects.
      datePublished:
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         Key words Pamidronate
         Osteolytic bone disease
         Oncology
         Nursing
         Nursing Research
         Pain Medicine
         Rehabilitation Medicine
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                  address:
                     name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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                     name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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                     name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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                     name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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            address:
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            address:
               name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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            address:
               name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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            address:
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      name:Department of Internal Medicine C, Division of Oncology – Hematology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland Tel.: +41–71–4941111 Fax: +41–71–4942878 email: [email protected] , , CH
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