We are analyzing https://link.springer.com/article/10.1007/s00467-007-0641-9.

Title:
Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring | Pediatric Nephrology
Description:
There is increasing evidence of vitamin D insufficiency in women of child-bearing age and their infants. This study examined the effect of maternal vitamin D deficiency on nephron endowment in rat offspring (n = 7 per group). Sprague–Dawley dams were fed either a vitamin D deplete diet or a vitamin replete (control) diet prior to pregnancy, during pregnancy and throughout lactation. At 4 weeks of age the offspring were weaned and maintained on their respective diets until they were killed at 7 weeks. In the fixed right kidney, kidney volume, renal corpuscle volume and nephron number were stereologically determined. There was no difference between groups in body weight, kidney weight or kidney volume. There was a significant 20% increase in nephron number in kidneys of vitamin D deplete offspring (vitamin D deficient, 29,000 ± 1,858, control, 23,330 ± 1,828; P = 0.04). This was accompanied by a significant decrease in renal corpuscle size in the vitamin D deplete group compared with the controls (6.125 ± 0.576 × 10−4 mm3 and 8.178 ± 0.247 × 10−4 mm3, respectively; P = 0.03). We concluded that maternal vitamin D deficiency in rats appears to stimulate nephrogenesis. Whether this confers a renal functional advantage or not is unknown.
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Keywords {🔍}

google, scholar, pubmed, cas, vitamin, renal, kidney, nephron, article, physiol, number, disease, int, deficiency, offspring, black, weight, rats, maternal, central, hypertension, bertram, adult, privacy, cookies, content, research, pregnancy, nephrogenesis, rat, morley, birth, blood, publish, search, volume, parkington, women, age, effect, access, clin, med, risk, development, pressure, data, area, information, log,

Topics {✒️}

month download article/chapter chronic renal disease advanced glycation end-products angiotensin-converting enzyme inhibition newborn renin-angiotensin system dark-skinned pregnant women human kidney development ang ii type renal vascular development ischaemic heart disease compensatory renal growth privacy choices/manage cookies multi-hit nature adult blood pressure full article pdf renal functional advantage programs adult hypertension renin-angiotensin system related subjects renal disease li yc renal corpuscle size renal corpuscle volume european economic area lactation stimulates nephrogenesis analyzing renal glomeruli birth weight related maternal nutrient restriction sprague–dawley dams long-term consequences efficient stereological methods parathyroid hormone concentrations negative endocrine regulator vera ramaciotti foundation nephron endowment reduced nephron number decreased nephron number conditions privacy policy author information authors maternal dexamethasone treatment prenatal glucocorticoid treatment receptor-null mice accepting optional cookies brown aj breast-fed newborns nutrition examination survey hanson ma salt-sensitive hypertension fetal spiny mouse physiology

Questions {❓}

Black MJ, Briscoe TA, Constantinou M, Kett MM, Bertram JF (2004) Is there an association between level of adult blood pressure and nephron number or renal filtration surface area and level of adult blood pressure?
Newsome CA, Shiell AW, Fall CH, Phillips DI, Shier R, Law CM (2003) Is birth weight related to later glucose and insulin metabolism?
Zimanyi MA, Bertram JF, Black MJ (2004) Does a nephron deficit in rats predispose to salt-sensitive hypertension?

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