We are analyzing https://link.springer.com/article/10.1007/s004410100417.

Title:
Function and interactions of integrins | Cell and Tissue Research
Description:
Integrins are heterodimeric cell adhesion molecules that link the extracellular matrix to the cytoskeleton. The integrin family in man comprises 24 members, which are the result of different combinations of 1 of 18 α- and 1 of 8 β-subunits. Alternative splicing of mRNA of some α- and β-subunits and postranslational modifications of integrin subunits further increase the diversity of the integrin family. In their capacity as adhesion receptors that organize the cytoskeleton, integrins play an important role in controlling various steps in the signaling pathways that regulate processes as diverse as proliferation, differentiation, apoptosis, and cell migration. The intracellular signals that lead to these effects may be transduced via cytoplasmic components, which have been identified as integrin-binding proteins in yeast two-hybrid screens and which could mediate the coupling of integrins to intracellular signaling pathways. In this review an overview is given of the function and ligand-binding properties of integrins as well as of proteins that associate with integrins and may play a role in their signaling function.
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Keywords {🔍}

article, integrins, research, cell, integrin, privacy, cookies, function, content, access, information, publish, search, adhesion, signaling, intracellular, proteins, data, log, journal, tissue, van, flier, sonnenberg, extracellular, discover, signalling, springer, optional, personal, parties, policy, find, track, interactions, review, september, cite, arjan, arnoud, explore, molecules, matrix, cytoskeleton, family, βsubunits, play, role, pathways, institution,

Topics {✒️}

month download article/chapter extracellular matrix integrin-binding proteins intracellular signaling pathways privacy choices/manage cookies full article pdf tissue research aims european economic area ligand-binding properties related subjects integrins review published conditions privacy policy article cell adhesion receptors sonnenberg accepting optional cookies september 2001 volume 305 integrin family integrin subunits intracellular signals main content log journal finder publish check access instant access signaling pathways cell migration research advances article log signaling function privacy policy article cite personal data books a integrins play optional cookies manage preferences proteins data protection essential cookies cookies skip subscription content similar content institution subscribe journal publish information usage analysis social media varying standards 8 β-subunits alternative splicing

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