We are analyzing https://link.springer.com/article/10.1007/s00441-014-2011-9.

Title:
The roles and regulation of Polycomb complexes in neural development | Cell and Tissue Research
Description:
In the developing mammalian nervous system, common progenitors integrate both cell extrinsic and intrinsic regulatory programs to produce distinct neuronal and glial cell types as development proceeds. This spatiotemporal restriction of neural progenitor differentiation is enforced, in part, by the dynamic reorganization of chromatin into repressive domains by Polycomb repressive complexes, effectively limiting the expression of fate-determining genes. Here, we review the distinct roles that Polycomb repressive complexes play during neurogenesis and gliogenesis, while also highlighting recent work describing the molecular mechanisms that govern their dynamic activity in neural development. Further investigation of the way in which Polycomb complexes are regulated in neural development will enable more precise manipulation of neural progenitor differentiation facilitating the efficient generation of specific neuronal and glial cell types for many biological applications.
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Keywords {🔍}

pubmed, google, scholar, cas, cell, central, stem, polycomb, cells, neural, chromatin, genes, development, differentiation, mol, complex, prc, noncoding, histone, rnas, embryonic, biol, dev, long, nat, zhang, gene, mouse, repressive, methylation, rna, wang, neuronal, human, nature, neurosci, regulation, neurogenesis, epigenetic, article, koseki, res, reinberg, protein, ezh, complexes, required, rev, bernstein, science,

Topics {✒️}

fbxl10/jhdm1b histone demethylase beta-catenin exerts effects stage-dependent fate determination mediate prc1-dependent repression neuronal-glial fate specification dna methylation cross-talk month download article/chapter jak-stat signaling pathway germ line-specific genes jumonji-cyclin d1 pathway jak-stat signaling controls histone h2a mono-ubiquitination polycomb associates genome-wide il-6-related cytokine signaling f-box protein fbl10 lineage-specific polycomb targets central nervous system stat3-smad1 complex bridged ring1b/rnf2 interactors identifies jarid2/jumonji coordinates control rna polymerase ii h3k27 demethylase jmjd3 regulates h2a ubiquitylation common progenitors integrate glia-restricted progenitors direct gene repression polycomb repressive complex produce distinct neuronal h3k27 facilitates recruitment bcl6 interacting corepressor human multiprotein complex polycomb repressive complexes privacy choices/manage cookies repressive histone marks histone-modified dna prc2 occupancy identifies polycomb protein eed embryonic stem cells neuronal progenitors polycomb-group silencing full article pdf histone h3 lys4 single factors direct qureshi ia chromatin immunoprecipitated dna recruiting prc1 complex target gene occupancy individual progenitor cells p21-rb pathway neural stem cells

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