We are analyzing https://link.springer.com/article/10.1007/s00441-013-1750-3.

Title:
Osteoblast ontogeny and implications for bone pathology: an overview | Cell and Tissue Research
Description:
Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this review is to provide an update on the nature of bone-forming osteoblastic cells, highlighting recent data on MSC—osteoblast—osteocyte transformation from a molecular perspective and to discuss osteoblast malfunctions in various bone diseases. We present here the consecutive stages occurring in the differentiation of osteoblasts from MSC, the transcription factors involved and the role of miRNAs in the process. Recent data concerning the pathogenic mechanisms underlying the loss of bone mass and architecture caused by malfunctions in the synthetic activity and metabolism of osteoblasts in osteoporosis, osteogenesis imperfecta, osteoarthritis and rheumatoid arthritis are discussed. The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
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Keywords {🔍}

pubmed, google, scholar, cas, bone, cells, cell, differentiation, stem, mesenchymal, osteoblast, central, osteoblasts, res, human, biol, stein, tissue, article, role, osteogenesis, biology, transcription, factors, van, expression, runx, rev, regulation, microrna, imperfecta, arthritis, skeletal, factor, zhang, function, osteoporosis, estrogen, mol, receptor, lee, miner, signaling, stromal, med, endocrinol, acad, sci, growth, karsenty,

Topics {✒️}

month download article/chapter mir-196a regulates proliferation mir-125b regulates calcification anti-tnf alpha antibody mesenchymal stromal cells bone-forming osteoblastic cells msc—osteoblast—osteocyte transformation authors gratefully acknowledge human adipose tissue runx/cbfa/aml factors mesenchymal stem cells trance/rankl knockout mice related subjects mesenchymal stem cell pathology “nicolae simionescu” regulating bmp signaling positive feedback loop human primary osteoblasts tissue research aims el baddini ma network connecting runx2 privacy choices/manage cookies modulating wnt signaling adult stem cells postnatal bone development article titorencu mir-26a targeting osteoblast derived component author correspondence smad1 transcription factor full article pdf osteogenesis imperfecta murine mir-29b contribute bone lining cells bone marrow sinusoids bone marrow stroma check access riggs bl transcription factor osterix dose-dependent effects instant access osteoblast ontogeny bone formation owing rowe dw de saint-georges defining mrna targets microrna regulatory mechanism kinase-mediated transcription directly targeting osterix bone tissue engineering

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      headline:Osteoblast ontogeny and implications for bone pathology: an overview
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