We are analyzing https://link.springer.com/article/10.1007/s00441-005-0127-7.

Title:
Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastroinstestinal tracts | Cell and Tissue Research
Description:
Previous studies have implicated antimicrobial peptides in the host defense of the mammalian intestinal and respiratory tract. The aim of the present study has been to characterize further the expression of these molecules in non-epithelial cells of the human pulmonary and digestive systems by detailed immunohistochemical analysis of the small and large bowel and of the large airways and lung parenchyma. Additionally, cells obtained from bronchoalveolar lavage were analyzed by fluorescent activated cell sorting and immunostaining of cytospin preparations. hBD-1, hBD-2, and LL-37 were detected in lymphocytes and macrophages in the large airways, lung parenchyma, duodenum, and colon. Lymphocytes positive for the peptides revealed a staining pattern and distribution that largely matched that of CD3-positive and CD8-positive T-cells. Macrophages with positive staining for the antimicrobial peptides also stained positively for CD68 and CD74. In view of the morphology of the LL-37-positive and hBD-2-positive mucosal lymphocytes, they are probably also B-cells. Thus, antimicrobial peptides of the defensin and cathelicidin families are present in a variety of non-epithelial cells of mucosal organs. These findings confirm that antimicrobial peptides have multiple functions in the biology of the mucosa of these organs.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter peptide antibiotic ll-37/hcap-18 antimicrobial lipopolysaccharide-binding protein epithelial cell-derived cathelicidin nf-kb binding motifs innate host defense cathelicidin antimicrobial peptide specific salt-sensitive spectrum pulmonary innate immunity host defense cells related subjects cd8-positive t-cells full article pdf salt-sensitive antibiotic human beta-defensins hbd-1 innate immunity privacy choices/manage cookies antibacterial peptide ll-37 human gene fall39 tissue research aims invasive bacterial infection natural products capable respiratory tract human beta-defensin 2 human beta-defensin 3 human beta-defensin 4 human beta-defensin-1 pia unterberger hbd-2-positive mucosal lymphocytes specific antimicrobial activity host defense computational search strategy multifunctional beta-defensin beta-defensin 1 contributes broad antimicrobial activity endogenous antibiotic peptides check access instant access peptide antibiotic implicated antimicrobial peptides multifunctional antimicrobial peptides endogenous antimicrobial peptides epithelial chloride secretion article cell article wah european economic area channel-forming cryptdins 2 peptide antibiotics conditions privacy policy human skin wounds

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         description:Previous studies have implicated antimicrobial peptides in the host defense of the mammalian intestinal and respiratory tract. The aim of the present study has been to characterize further the expression of these molecules in non-epithelial cells of the human pulmonary and digestive systems by detailed immunohistochemical analysis of the small and large bowel and of the large airways and lung parenchyma. Additionally, cells obtained from bronchoalveolar lavage were analyzed by fluorescent activated cell sorting and immunostaining of cytospin preparations. hBD-1, hBD-2, and LL-37 were detected in lymphocytes and macrophages in the large airways, lung parenchyma, duodenum, and colon. Lymphocytes positive for the peptides revealed a staining pattern and distribution that largely matched that of CD3-positive and CD8-positive T-cells. Macrophages with positive staining for the antimicrobial peptides also stained positively for CD68 and CD74. In view of the morphology of the LL-37-positive and hBD-2-positive mucosal lymphocytes, they are probably also B-cells. Thus, antimicrobial peptides of the defensin and cathelicidin families are present in a variety of non-epithelial cells of mucosal organs. These findings confirm that antimicrobial peptides have multiple functions in the biology of the mucosa of these organs.
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         Innate immunity
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         Host defense
         Human
         Human Genetics
         Proteomics
         Molecular Medicine
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