We are analyzing https://link.springer.com/article/10.1007/s00441-002-0564-5.

Title:
Immunoreactive substance P is not part of the retinohypothalamic tract in the rat | Cell and Tissue Research
Description:
Cell and Tissue Research - The retinohypothalamic tract (RHT) is a monosynaptic retinofugal pathway mediating information concerning the light/dark cycle from the retina to the brain
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article, scn, rht, information, cell, privacy, cookies, content, research, retina, spimmunoreactive, data, publish, search, substance, nerve, fibres, cells, access, log, journal, tissue, immunoreactive, part, retinohypothalamic, tract, rat, hannibal, fahrenkrug, pacap, layer, circadian, chapter, discover, springer, optional, personal, parties, policy, find, track, cite, jens, jan, explore, clock, located, suprachiasmatic, nucleus, pituitary,

Topics {✒️}

pacap/chb-labelled nerve fibres month download article/chapter sp-immunoreactive nerve terminals glutamate-induced phase shifts sp-immunoreactive nerve fibres circadian timing system pacap-immunoreactive ganglion cells tissue research aims privacy choices/manage cookies article hannibal full article pdf related subjects ganglion cell layer sp-immunoreactive cells nuclear cell layer european economic area biological clock located sp immunoreactivity occurs bilateral eye enucleation dk-2400 copenhagen nv conditions privacy policy light/dark cycle displaced amacrine cells accepting optional cookies suprachiasmatic nucleus 1007/s00441-002-0564-5 immunohistochemistry main content log journal finder publish light information article cell fahrenkrug immunoreactive substance privacy policy immunoreactive neurons article log amacrine cells books a personal data optional cookies article cite manage preferences modulates photic sp immunoreaction check access instant access information plexiform layer essential cookies cookies skip subscription content

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         headline:Immunoreactive substance P is not part of the retinohypothalamic tract in the rat
         description: The retinohypothalamic tract (RHT) is a monosynaptic retinofugal pathway mediating information concerning the light/dark cycle from the retina to the brain's biological clock located in the suprachiasmatic nucleus (SCN). Light information, which daily adjusts (entrains) the rhythms of behaviour and physiology generated by the SCN, is mediated by two neurotransmitters, viz. glutamate and pituitary adenylate cyclase activating polypeptide (PACAP), co-stored in the RHT. Substance P (SP) modulates photic- and glutamate-induced phase shifts but data on its possible presence in the RHT are conflicting. By labelling the RHT projection in the SCN with the anterograde tracer cholera toxin subunit B (ChB) and antibodies against PACAP, we have shown that SP immunoreaction is absent from the PACAP/ChB-labelled nerve fibres in the SCN, indicating that the SP-immunoreactive nerve fibres are not part of the RHT but may originate from SP-immunoreactive cell bodies located within the SCN. In the retina, SP immunoreactivity occurs in amacrine cells in the inner nuclear cell layer, in a few displaced amacrine cells in the ganglion cell layer and in a dense plexus of SP-immunoreactive nerve terminals of the inner plexiform layer. Double immunostaining has revealed that SP-immunoreactive cells and fibres in the retina are not identical with the PACAP-immunoreactive ganglion cells that constitute the RHT. These findings together with the demonstration that bilateral eye enucleation does not decrease the number of SP-immunoreactive nerve fibres in the SCN indicate that SP is not a neurotransmitter in the RHT but could be an intrinsic neurotransmitter of the SCN modulating photic input to the clock.
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            Immunohistochemistry Co-localization Pituitary adenylate cyclase-activating polypeptide Cholera toxin subunit B Suprachiasmatic nucleus Entrainment Circadian rhythm Rat (Wistar, male)
            Human Genetics
            Proteomics
            Molecular Medicine
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      headline:Immunoreactive substance P is not part of the retinohypothalamic tract in the rat
      description: The retinohypothalamic tract (RHT) is a monosynaptic retinofugal pathway mediating information concerning the light/dark cycle from the retina to the brain's biological clock located in the suprachiasmatic nucleus (SCN). Light information, which daily adjusts (entrains) the rhythms of behaviour and physiology generated by the SCN, is mediated by two neurotransmitters, viz. glutamate and pituitary adenylate cyclase activating polypeptide (PACAP), co-stored in the RHT. Substance P (SP) modulates photic- and glutamate-induced phase shifts but data on its possible presence in the RHT are conflicting. By labelling the RHT projection in the SCN with the anterograde tracer cholera toxin subunit B (ChB) and antibodies against PACAP, we have shown that SP immunoreaction is absent from the PACAP/ChB-labelled nerve fibres in the SCN, indicating that the SP-immunoreactive nerve fibres are not part of the RHT but may originate from SP-immunoreactive cell bodies located within the SCN. In the retina, SP immunoreactivity occurs in amacrine cells in the inner nuclear cell layer, in a few displaced amacrine cells in the ganglion cell layer and in a dense plexus of SP-immunoreactive nerve terminals of the inner plexiform layer. Double immunostaining has revealed that SP-immunoreactive cells and fibres in the retina are not identical with the PACAP-immunoreactive ganglion cells that constitute the RHT. These findings together with the demonstration that bilateral eye enucleation does not decrease the number of SP-immunoreactive nerve fibres in the SCN indicate that SP is not a neurotransmitter in the RHT but could be an intrinsic neurotransmitter of the SCN modulating photic input to the clock.
      datePublished:
      dateModified:
      pageStart:293
      pageEnd:299
      sameAs:https://doi.org/10.1007/s00441-002-0564-5
      keywords:
         Immunohistochemistry Co-localization Pituitary adenylate cyclase-activating polypeptide Cholera toxin subunit B Suprachiasmatic nucleus Entrainment Circadian rhythm Rat (Wistar, male)
         Human Genetics
         Proteomics
         Molecular Medicine
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