We are analyzing https://link.springer.com/article/10.1007/s004390050257.

Title:
The apolipoprotein E polymorphism in Greenland Inuit in its global perspective | Human Genetics
Description:
Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The ɛ2 allele was absent in the latter sample, and the ɛ4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with ɛ4 than in ɛ3ɛ3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that ɛ4, and not ɛ3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
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Keywords {🔍}

article, apolipoprotein, access, gerdes, allele, privacy, cookies, content, polymorphism, aarhus, data, information, publish, search, inuit, christian, apoe, open, log, journal, research, genetics, greenland, hansen, population, cholesterol, women, study, discover, springer, optional, personal, parties, policy, find, track, human, global, perspective, september, cite, peter, steen, klausen, ole, faergeman, jørn, dyerberg, explore, genotypes,

Topics {✒️}

population-based 10-year follow plasma lipoprotein-related variables month download article/chapter ib christian klausen ɛ4 allele frequency inuit population samples related subjects privacy choices/manage cookies full article pdf human primates suggests generate additional hypotheses apoe allele frequencies european economic area scope submit manuscript south-west coast south-east coast coronary heart disease coronary artery disease check access instant access conditions privacy policy high-density lipoprotein aboriginal peoples peter steen hansen accepting optional cookies recent study hakka postmenopausal women main content log journal finder publish usage analysis september 1996 volume 98 global perspective article log article gerdes ɛ2 allele hdl cholesterol ancestral allele article cite sample privacy policy christian gerdes books a personal data optional cookies manage preferences dk-1304 københavn information cholesterol essential cookies cookies skip

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         description: Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The ɛ2 allele was absent in the latter sample, and the ɛ4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with ɛ4 than in ɛ3ɛ3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that ɛ4, and not ɛ3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
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            Triglyceride
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            Aboriginal People
            Human Genetics
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      headline:The apolipoprotein E polymorphism in Greenland Inuit in its global perspective
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         Triglyceride
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         Human Genetics
         Molecular Medicine
         Gene Function
         Metabolic Diseases
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