We are analyzing https://link.springer.com/article/10.1007/s00439-016-1683-5.

Title:
The hnRNP family: insights into their role in health and disease | Human Genetics
Description:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
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Keywords {🔍}

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Topics {✒️}

ca-rich element-binding micrornas delphine bouhy & vincent timmerman p62-positive/tdp43-negative inclusions c-jun n-terminal kinase amyotrophic lateral sclerosis lópez de silanes double-stranded rna-binding domain arg-gly-gly amino acids c9orf72 repeat expansion cyclin-dependent kinase inhibitor tgf-β-mediated emt resulted fronto-temporal lobe dementia article download pdf spinal muscular atrophy polypyrimidine tract-binding protein cytosine/thymidine-rich element single-stranded telomere dna van roon-mom wmc stranded antiparallel β-sheets tgf-beta-mediated phosphorylation c9orf72 als/ftd diseases arg-gly-gly repeats glycine-rich auxiliary domain �-opoid receptor gene c9orf72 repeat expansions human cerebrospinal fluid pre-rrna-binding proteins glycine-rich domain constituting coding rnas context-dependent regulatory mechanism reported post-translational modifications regulates cap-independent translation mrna-destabilizing sequences located c-myc transcription factor g-tract rna sequence telomeric dna-binding activities cell type-restricted activity uv-cross-linking experiments hnrnp a2/b1-mirna complexes develop rna-based therapies multiple rna-binding proteins glycine-rich c-terminus post-transcriptional regulatory roles αcp rna-binding proteins messenger-rna-binding proteins epithelial–mesenchymal transition pathway shared rna-binding properties common rna-binding properties transcript-selective translational induction full size image

Schema {🗺️}

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         headline:The hnRNP family: insights into their role in health and disease
         description:Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
         datePublished:2016-05-23T00:00:00Z
         dateModified:2016-05-23T00:00:00Z
         pageStart:851
         pageEnd:867
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            Spinal Muscular Atrophy
            Amyotrophic Lateral Sclerosis Patient
            C9orf72 Repeat Expansion
            Auxiliary Domain
            hnRNP Family
            Human Genetics
            Molecular Medicine
            Gene Function
            Metabolic Diseases
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      headline:The hnRNP family: insights into their role in health and disease
      description:Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
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      dateModified:2016-05-23T00:00:00Z
      pageStart:851
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      keywords:
         Spinal Muscular Atrophy
         Amyotrophic Lateral Sclerosis Patient
         C9orf72 Repeat Expansion
         Auxiliary Domain
         hnRNP Family
         Human Genetics
         Molecular Medicine
         Gene Function
         Metabolic Diseases
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                     type:PostalAddress
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            name:Delphine Bouhy
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                  name:University of Antwerp-CDE
                  address:
                     name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
                     type:PostalAddress
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                  address:
                     name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
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                     type:PostalAddress
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      address:
         name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
         type:PostalAddress
      name:University of Antwerp-CDE
      address:
         name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
         type:PostalAddress
      name:Institute Born Bunge, University of Antwerp
      address:
         name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
         type:PostalAddress
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         type:PostalAddress
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Person:
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            address:
               name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
               type:PostalAddress
            type:Organization
            name:Institute Born Bunge, University of Antwerp
            address:
               name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
               type:PostalAddress
            type:Organization
      name:Delphine Bouhy
      affiliation:
            name:University of Antwerp-CDE
            address:
               name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
               type:PostalAddress
            type:Organization
            name:Institute Born Bunge, University of Antwerp
            address:
               name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
               type:PostalAddress
            type:Organization
      name:Vincent Timmerman
      affiliation:
            name:University of Antwerp-CDE
            address:
               name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
               type:PostalAddress
            type:Organization
            name:Institute Born Bunge, University of Antwerp
            address:
               name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
               type:PostalAddress
            type:Organization
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PostalAddress:
      name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
      name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
      name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
      name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
      name:Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Antwerp, Belgium
      name:Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium

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