We are analyzing https://link.springer.com/article/10.1007/s00432-022-03923-4.

Title:
Radiotherapy resistance: identifying universal biomarkers for various human cancers | Journal of Cancer Research and Clinical Oncology
Description:
Radiotherapy (RT) is considered as a standard in the treatment of most solid cancers, including glioblastoma, lung, breast, rectal, prostate, colorectal, cervical, esophageal, and head and neck cancers. The main challenge in RT is tumor cell radioresistance associated with a high risk of locoregional relapse and distant metastasis. Despite significant progress in understanding mechanisms of radioresistance, its prediction and overcoming remain unresolved. This review presents the state-of-the-art for the potential universal biomarkers correlated to the radioresistance and poor outcome in different cancers. We describe radioresistance biomarkers functionally attributed to DNA repair, signal transduction, hypoxia, and angiogenesis. We also focus on high throughput genetic and proteomic studies, which revealed a set of molecular biomarkers related to radioresistance. In conclusion, we discuss biomarkers which are overlapped in most several cancers.
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Keywords {🔍}

pubmed, article, google, scholar, cancer, cas, central, cell, radiotherapy, oncol, carcinoma, expression, radioresistance, patients, httpsdoiorgs, lung, radiation, squamous, cells, int, cervical, response, head, neck, res, clin, httpsdoiorg, cancers, rectal, resistance, biol, prognosis, biomarkers, tumor, poor, therapy, sci, treated, radiat, med, chemoradiotherapy, wang, nasopharyngeal, prognostic, biomarker, mol, esophageal, dna, radiosensitivity, zhang,

Topics {✒️}

month download article/chapter article google scholar cell-cycle-controlled radiation therapy adaptive foxp3+cd4+ regulatory radiation-induced signaling pathways foxo1/tgfβ1 signaling loop swebcg91-rt randomised trial small-cell lung carcinoma y-box-binding protein-1 pd-l1 mediates peripheral pkc-delta signaling pathway squamous cell carcinoma-antigen small-cell lung cancer activating nrf2/nqo1 axis radiation-induced vascular damage downregulating mir-450b-5p double-strand breaks sp1-mediated transcriptional activation de jong mc cd103+ tumor-infiltrating lymphocytes tumor-reactive intraepithelial cd8+ full article pdf cdk inhibitor–chemotherapy combinations hypoxia-inducible factors 1alpha locally advanced n2 recurrent/radioresistant cervical cancer clinical oncology aims hpv-negative head article larionova biomarkers predicts radioresistance squamous cell carcinoma cd11b+ myeloid cells pd-l1 blockade privacy choices/manage cookies mir-18a-5p reactive oxygen species identifying universal biomarkers molecular biomarkers related cells independently predict circulating exosomal mir-96 rectal cancer treated fibroblast-induced resistance nf-κb signaling affecting dna repair radiation-induced microrna-622 cancer research institute amaral westin mc mediates radiation resistance advanced cervical cancer related subjects

Questions {❓}

Baskar R, Itahana K (2017) Radiation therapy and cancer control in developing countries: can we save more lives?
Das M, Abdelmaksoud MHK, Loo BWJ, Kothary N (2010) Alternatives to surgery for early stage non-small cell lung cancer-ready for prime time?
Swanton C, Marcus S, Jayamohan J et al (2021) Can adjuvant pelvic radiation therapy after local excision or polypectomy for T1 and T2 rectal cancer offer an alternative option to radical surgery?
Wang H, Jiang H, Van De Gucht M, De Ridder M (2019b) Hypoxic radioresistance: can ROS be the key to overcome It?

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