We are analyzing https://link.springer.com/article/10.1007/s00432-019-02844-z.

Title:
Pre-orchiectomy tumor marker levels should not be used for International Germ Cell Consensus Classification (IGCCCG) risk group assignment | Journal of Cancer Research and Clinical Oncology
Description:
Purpose To investigate whether the use of pre-orchiectomy instead of pre-chemotherapy tumor marker (TM) levels has an impact on the International Germ Cell Consensus Classification (IGCCCG) risk group assignment in patients with metastatic germ cell tumors (GCT). Methods Demographic and clinical information of all patients treated for primary metastatic testicular non-seminomatous GCT in our tertiary care academic center were extracted from medical charts. IGCCCG risk group assignment was correctly performed with pre-chemotherapy marker levels and additionally with pre-orchiectomy marker levels. Agreement between pre-chemotherapy and pre-orchiectomy risk group assignments was assessed using Cohen’s kappa. Results Our cohort consisted of 83 patients. The use of pre-orchiectomy TMs resulted in an IGCCCG risk group upstaging in 12 patients (16%, 8 patients from good to intermediate risk and 4 patients from intermediate to poor risk) and a downstaging in 1 patient (1.2%, from intermediate- to good-risk). The agreement between pre-orchiectomy and pre-chemotherapy IGCCCG risk groups resulted in a Cohen’s kappa of 0.888 (p < 0.001). Conclusions Using pre-orchiectomy TMs can result in incorrect IGCCCG risk group assignment, which in turn can impact on the clinical management and follow-up of patients with metastatic GCT. Thus, adherence to the IGCCCG standard using pre-chemotherapy TMs levels is recommended.
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article, cancer, risk, preorchiectomy, germ, cell, igcccg, group, google, scholar, patients, pubmed, research, tumor, levels, oncol, privacy, cookies, journal, clinical, marker, international, consensus, assignment, beyer, prechemotherapy, testicular, clin, content, data, information, publish, search, oncology, classification, christian, daniel, joerg, metastatic, access, cas, author, university, consent, standards, log, january, fankhauser, gerke, roth,

Topics {✒️}

month download article/chapter germ-cell tumor survivors pre-chemotherapy tumor marker pre-orchiectomy marker levels pre-chemotherapy marker levels pre-orchiectomy tms resulted pre-chemotherapy tms levels germ-cell cancer risk group assignment standard cisplatin-based chemotherapy testicular cancer survivors nonseminoma testicular cancer clinical oncology aims joerg beyer pre-orchiectomy tms full article pdf primary metastatic testicular privacy choices/manage cookies moffitt cancer center european consensus conference nico christian grossmann national research committee population-based cohort article fankhauser european economic area long-term toxicity local ethic committee stv kek-zh 25-2008 conditions privacy policy multi-institutional study cancer research pre-orchiectomy accepting optional cookies pre-chemotherapy article journal long-term follow author correspondence ethics declarations conflict clinical information journal finder publish main content log comparable ethical standards reducing treatment burden article log medical oncology tullio sulser check access instant access article cite clinical management

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         description:To investigate whether the use of pre-orchiectomy instead of pre-chemotherapy tumor marker (TM) levels has an impact on the International Germ Cell Consensus Classification (IGCCCG) risk group assignment in patients with metastatic germ cell tumors (GCT). Demographic and clinical information of all patients treated for primary metastatic testicular non-seminomatous GCT in our tertiary care academic center were extracted from medical charts. IGCCCG risk group assignment was correctly performed with pre-chemotherapy marker levels and additionally with pre-orchiectomy marker levels. Agreement between pre-chemotherapy and pre-orchiectomy risk group assignments was assessed using Cohen’s kappa. Our cohort consisted of 83 patients. The use of pre-orchiectomy TMs resulted in an IGCCCG risk group upstaging in 12 patients (16%, 8 patients from good to intermediate risk and 4 patients from intermediate to poor risk) and a downstaging in 1 patient (1.2%, from intermediate- to good-risk). The agreement between pre-orchiectomy and pre-chemotherapy IGCCCG risk groups resulted in a Cohen’s kappa of 0.888 (p < 0.001). Using pre-orchiectomy TMs can result in incorrect IGCCCG risk group assignment, which in turn can impact on the clinical management and follow-up of patients with metastatic GCT. Thus, adherence to the IGCCCG standard using pre-chemotherapy TMs levels is recommended.
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            Biomarkers, tumor
            Prognosis
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
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      description:To investigate whether the use of pre-orchiectomy instead of pre-chemotherapy tumor marker (TM) levels has an impact on the International Germ Cell Consensus Classification (IGCCCG) risk group assignment in patients with metastatic germ cell tumors (GCT). Demographic and clinical information of all patients treated for primary metastatic testicular non-seminomatous GCT in our tertiary care academic center were extracted from medical charts. IGCCCG risk group assignment was correctly performed with pre-chemotherapy marker levels and additionally with pre-orchiectomy marker levels. Agreement between pre-chemotherapy and pre-orchiectomy risk group assignments was assessed using Cohen’s kappa. Our cohort consisted of 83 patients. The use of pre-orchiectomy TMs resulted in an IGCCCG risk group upstaging in 12 patients (16%, 8 patients from good to intermediate risk and 4 patients from intermediate to poor risk) and a downstaging in 1 patient (1.2%, from intermediate- to good-risk). The agreement between pre-orchiectomy and pre-chemotherapy IGCCCG risk groups resulted in a Cohen’s kappa of 0.888 (p < 0.001). Using pre-orchiectomy TMs can result in incorrect IGCCCG risk group assignment, which in turn can impact on the clinical management and follow-up of patients with metastatic GCT. Thus, adherence to the IGCCCG standard using pre-chemotherapy TMs levels is recommended.
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         Biomarkers, tumor
         Prognosis
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
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