We are analyzing https://link.springer.com/article/10.1007/s00432-014-1871-4.

Title:
Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma | Journal of Cancer Research and Clinical Oncology
Description:
To investigate the expression of SRHC and the role of SRHC in the pathogenesis of hepatocellular carcinoma (HCC). We analyzed HCC samples and matched non-tumor liver tissues (controls) collected from 81 patients who underwent hepatectomy in Shanghai, China. The expression levels of SRHC were determined by quantitative reverse-transcription polymerase chain reaction. Statistical analyses were used to associate the levels of SRHC with tumor features and patient outcomes. We found that a lower SRHC expression level was significantly more frequent in tissues with a high serum a-fetoprotein level (positive, >20 µg/L, P = 0.004) and a low degree of differentiated tumors (poorly differentiated, P = 0.017). Furthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation. Here, we identified a new long noncoding RNA designated as SRHC that is capable of inhibiting cancer proliferation and is down-regulated in tumors at least partly by DNA methylation.
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Keywords {🔍}

pubmed, article, google, scholar, cas, hepatocellular, carcinoma, cancer, long, central, expression, noncoding, srhc, factor, yang, nuclear, yuan, wang, cell, rna, hepatocyte, res, research, promotes, sun, access, rnas, hepatology, zhang, alpha, privacy, cookies, content, journal, zhou, hepatitis, doihep, supplementary, material, information, publish, search, proliferation, zheng, hongli, yan, role, liver, shanghai, china,

Topics {✒️}

month download article/chapter shu-han sun liver-enriched transcription factors wei-ping zhou h19-mediated metastasis suppression darnell je jr liver-specific gene expression clinical oncology aims human hepatocellular carcinoma long noncoding rna hong-li yan long noncoding rnas full article pdf hepatocyte nuclear factors coding rna malat1 inhibiting cancer proliferation insertion/deletion polymorphism hepatocellular carcinoma based cpg-rich island pre-mrna splicing hypoxia-mediated metastasis li-li wang molecular viral oncology privacy choices/manage cookies related subjects nuclear receptor 2a1 article zheng hepatic gene expression autophagy suppresses tumorigenesis orphan receptor hnf-4 article journal dna methylation status hepatocellular carcinoma article log european economic area bile acid biosynthesis swi/snf complex mir-200 family contributes author information authors military medical university cell culture model conditions privacy policy check access instant access expression profiling suggested detailed bioinformatics analysis article cite sheng-xian yuan ltb genes underlies tumor liver tissues

Schema {🗺️}

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         headline:Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma
         description: To investigate the expression of SRHC and the role of SRHC in the pathogenesis of hepatocellular carcinoma (HCC). We analyzed HCC samples and matched non-tumor liver tissues (controls) collected from 81 patients who underwent hepatectomy in Shanghai, China. The expression levels of SRHC were determined by quantitative reverse-transcription polymerase chain reaction. Statistical analyses were used to associate the levels of SRHC with tumor features and patient outcomes. We found that a lower SRHC expression level was significantly more frequent in tissues with a high serum a-fetoprotein level (positive, >20 µg/L, P = 0.004) and a low degree of differentiated tumors (poorly differentiated, P = 0.017). Furthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation. Here, we identified a new long noncoding RNA designated as SRHC that is capable of inhibiting cancer proliferation and is down-regulated in tumors at least partly by DNA methylation.
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            Splicing
            SRHC
            LncRNA
            Methylation
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
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      headline:Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma
      description: To investigate the expression of SRHC and the role of SRHC in the pathogenesis of hepatocellular carcinoma (HCC). We analyzed HCC samples and matched non-tumor liver tissues (controls) collected from 81 patients who underwent hepatectomy in Shanghai, China. The expression levels of SRHC were determined by quantitative reverse-transcription polymerase chain reaction. Statistical analyses were used to associate the levels of SRHC with tumor features and patient outcomes. We found that a lower SRHC expression level was significantly more frequent in tissues with a high serum a-fetoprotein level (positive, >20 µg/L, P = 0.004) and a low degree of differentiated tumors (poorly differentiated, P = 0.017). Furthermore, we found that the promoter region of SRHC contains a CpG-rich island and that SRHC is down-regulated in tumors by DNA methylation. Here, we identified a new long noncoding RNA designated as SRHC that is capable of inhibiting cancer proliferation and is down-regulated in tumors at least partly by DNA methylation.
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      dateModified:2014-12-16T00:00:00Z
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         Hepatocellular carcinoma
         Splicing
         SRHC
         LncRNA
         Methylation
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
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