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month download article/chapter hab18g/cd147-mediated metastasis process 92-kda type-iv collagenase shorter progression-free survival salivary gland cancer salivary duct carcinoma cancerous salivary tissue full article pdf mammary duct carcinoma tumor cell surface involvement emmprin mt1-mmp human hepatoma cells preventing hepatoma recurrence privacy choices/manage cookies cell surface regulator matrix metalloproteinase production hepatocellular carcinoma patients differing metastatic potentials adenovirus-mediated transfer related subjects serous ovarian carcinoma tumor-infiltrating lymphocytes laryngeal cancer cells medical pathology disease-free survival article piao disease-specific survival bin zhang clinical oncology aims superficial oesophageal cancer european economic area immunoglobulin super family stetler-stevenson wg negative regulatory elements post-trial era randomized controlled trial check access instant access tumor cd147 expression conditions privacy policy bmc cancer 10 article journal cyclooxygenase-2 expression correlates colorectal cancer patients matrix metalloproteinase synthesis previously untreated patients hepatocellular carcinoma accepting optional cookies article log matrix-metalloproteinase-2 expression

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         headline:Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma
         description:The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC. We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC. Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (P CD147 = 0.031; P MMP-9 = 0.020) and overall survival (OS) (P CD147 = 0.044; P MMP-9 = 0.013). CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.
         datePublished:2012-01-04T00:00:00Z
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            MMP-9
            Salivary duct carcinoma
            Cancer prognosis
            Metastasis
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
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      headline:Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma
      description:The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC. We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC. Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (P CD147 = 0.031; P MMP-9 = 0.020) and overall survival (OS) (P CD147 = 0.044; P MMP-9 = 0.013). CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.
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      dateModified:2012-01-04T00:00:00Z
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         CD147
         MMP-9
         Salivary duct carcinoma
         Cancer prognosis
         Metastasis
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
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