We are analyzing https://link.springer.com/article/10.1007/s00432-011-0998-9.

Title:
Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer | Journal of Cancer Research and Clinical Oncology
Description:
Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, has been associated with metastasis, therapy resistance, and cell-cycle progression. The purpose of this study was to investigate the expression level of USP22 in breast samples and to evaluate its clinical significance in breast cancer patients. Immunohistochemistry was used to determine the expression of USP22 protein in 31 breast fibroadenoma and 100 breast cancer patients in comparison with 34 normal breast specimens. Furthermore, we analyzed the correlation between the expression of the USP22 protein and various clinicopathologic factors including survival status of patients with breast cancer. The immunohistochemistry results showed that the expression level of USP22 protein in breast cancer samples was significantly higher than that in breast fibroadenoma and normal breast tissues (P = 0.003 and P = 0.021). Moreover, statistical analysis showed that high USP22 expression was positively related to lymph node metastasis, Her-2, Ki67, and recurrence. Furthermore, it was shown that patients with high USP22 expression had significantly poorer outcome compared with patients with low expression of USP22 for patients with positive lymph nodes. Multivariate Cox regression analysis revealed that USP22 expression level was an independent prognostic factor for both overall survival and disease-free survival (P = 0.039 and P = 0.041, respectively). Overexpression of USP22 may contribute to the progression of breast cancer and thus may serve as a new molecular marker to predict the prognosis of breast cancer patients.
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Keywords {🔍}

article, cancer, google, scholar, pubmed, cas, breast, usp, cell, expression, zhang, patients, analysis, histone, prognosis, metastasis, protein, mol, privacy, cookies, content, journal, research, access, gene, cycle, harbin, information, publish, search, yao, pang, lymph, complex, genes, biol, department, function, data, log, clinical, correlation, poor, june, youxue, lei, protease, deubiquitinating, therapy, progression,

Topics {✒️}

month download article/chapter myc/max/mad network myc-dependent trrap recruitment lymph node metastasis lihong wang & da pang triple-negative breast cancer differentially expressed proteins prognostic markers independent prognostic factor histone h2b ubiquitination ubiquitin-specific protease 14 full article pdf invasive breast cancer positive lymph nodes privacy choices/manage cookies stem cell contribution clinical oncology aims cyclin d2 promoter discrete functional module h2b ubiquitylation acts dr yanlong liu metastasis-enabling phenotype apoptosis-related genes breast cancer samples saga-related complex histone deacetylase inhibitors normal breast tissues cancerous breast tissue c-myc global cancer statistics bladder cancer cells da pang article zhang immunohistochemistry results showed breast cancer patients european economic area disease-free survival chorionic villi derived epigenetic events underlie polycomb-catalyzed ubiquitylation coactivates nuclear receptors counteracts heterochromatin silencing excellent technical assistance microarray analysis identifies conditions privacy policy article journal activated polycomb group cell-cycle progression statistical analysis showed harbin medical university

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         description:Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, has been associated with metastasis, therapy resistance, and cell-cycle progression. The purpose of this study was to investigate the expression level of USP22 in breast samples and to evaluate its clinical significance in breast cancer patients. Immunohistochemistry was used to determine the expression of USP22 protein in 31 breast fibroadenoma and 100 breast cancer patients in comparison with 34 normal breast specimens. Furthermore, we analyzed the correlation between the expression of the USP22 protein and various clinicopathologic factors including survival status of patients with breast cancer. The immunohistochemistry results showed that the expression level of USP22 protein in breast cancer samples was significantly higher than that in breast fibroadenoma and normal breast tissues (P = 0.003 and P = 0.021). Moreover, statistical analysis showed that high USP22 expression was positively related to lymph node metastasis, Her-2, Ki67, and recurrence. Furthermore, it was shown that patients with high USP22 expression had significantly poorer outcome compared with patients with low expression of USP22 for patients with positive lymph nodes. Multivariate Cox regression analysis revealed that USP22 expression level was an independent prognostic factor for both overall survival and disease-free survival (P = 0.039 and P = 0.041, respectively). Overexpression of USP22 may contribute to the progression of breast cancer and thus may serve as a new molecular marker to predict the prognosis of breast cancer patients.
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      description:Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, has been associated with metastasis, therapy resistance, and cell-cycle progression. The purpose of this study was to investigate the expression level of USP22 in breast samples and to evaluate its clinical significance in breast cancer patients. Immunohistochemistry was used to determine the expression of USP22 protein in 31 breast fibroadenoma and 100 breast cancer patients in comparison with 34 normal breast specimens. Furthermore, we analyzed the correlation between the expression of the USP22 protein and various clinicopathologic factors including survival status of patients with breast cancer. The immunohistochemistry results showed that the expression level of USP22 protein in breast cancer samples was significantly higher than that in breast fibroadenoma and normal breast tissues (P = 0.003 and P = 0.021). Moreover, statistical analysis showed that high USP22 expression was positively related to lymph node metastasis, Her-2, Ki67, and recurrence. Furthermore, it was shown that patients with high USP22 expression had significantly poorer outcome compared with patients with low expression of USP22 for patients with positive lymph nodes. Multivariate Cox regression analysis revealed that USP22 expression level was an independent prognostic factor for both overall survival and disease-free survival (P = 0.039 and P = 0.041, respectively). Overexpression of USP22 may contribute to the progression of breast cancer and thus may serve as a new molecular marker to predict the prognosis of breast cancer patients.
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