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Title:
Clinical and haemodynamic correlates of heart rate variability in children with congenital heart disease | European Journal of Pediatrics
Description:
Heart rate variability (HRV) represents a noninvasive parameter for studying the autonomic control of the heart. Cardiac patients have a complex autonomic disturbance. The relation of HRV to this abnormality in children with congenital heart disease (CHD) has not yet been examined. The present study examined HRV indices from 24βh Holter recordings in 258 children with an operated or non-operated CHD, to determine their differences as an indicator of the severity of heart disease. The latter was defined clinically as New York Heart Association (NYHA) functional class I to IV and haemodynamically by invasive parameters. Five time-domain measures (SDNN, SDNNi, SDANNi, rMSSD and pNN50) and three frequency-domain measures (LF, HF and balance LF/HF) were compared with normal ranges. HRV was reduced in children with CHD, except in patients of NYHA class I. The level of reduction depended on the NYHA functional class. None of the measures was significantly related to haemodynamic data. Conclusion Heart rate variability is reduced in children with Congenital heart disease depending on the functional limitation but not on haemodynamic disturbances. Heart rate variability indices are sensitive markers of the clinical state.
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heart, article, rate, variability, congenital, disease, children, privacy, cookies, content, journal, access, data, information, publish, search, haemodynamic, hrv, european, log, research, pediatrics, clinical, massin, bernuth, complex, chd, nyha, functional, class, measures, related, discover, springer, optional, personal, parties, policy, find, track, correlates, cardiology, cite, explore, autonomic, patients, examined, indices, reduced, state,
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congenital heart disease heart rate variability month download article/chapter complex autonomic disturbance york heart association heart disease article european journal privacy choices/manage cookies full article pdf european economic area related subjects scope submit manuscript early transitional period check access instant access conditions privacy policy pediatrics aims time-domain measures frequency-domain measures journal finder publish accepting optional cookies von bernuth main content log balance lf/hf nyha functional class article log significantly related heart clinical state article cite article massin privacy policy information personal data paediatric cardiology books a journal publish optional cookies manage preferences functional class essential cookies cookies skip subscription content similar content data protection autonomic control haemodynamic data institution subscribe nyha class functional limitation
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headline:Clinical and haemodynamic correlates of heart rate variability in children with congenital heart disease
description: Heart rate variability (HRV) represents a noninvasive parameter for studying the autonomic control of the heart. Cardiac patients have a complex autonomic disturbance. The relation of HRV to this abnormality in children with congenital heart disease (CHD) has not yet been examined. The present study examined HRV indices from 24βh Holter recordings in 258 children with an operated or non-operated CHD, to determine their differences as an indicator of the severity of heart disease. The latter was defined clinically as New York Heart Association (NYHA) functional class I to IV and haemodynamically by invasive parameters. Five time-domain measures (SDNN, SDNNi, SDANNi, rMSSD and pNN50) and three frequency-domain measures (LF, HF and balance LF/HF) were compared with normal ranges. HRV was reduced in children with CHD, except in patients of NYHA class I. The level of reduction depended on the NYHA functional class. None of the measures was significantly related to haemodynamic data.
Conclusion Heart rate variability is reduced in children with Congenital heart disease depending on the functional limitation but not on haemodynamic disturbances. Heart rate variability indices are sensitive markers of the clinical state.
datePublished:
dateModified:
pageStart:967
pageEnd:971
sameAs:https://doi.org/10.1007/s004310050979
keywords:
Key words Heart rate variability
Childhood
Haemodynamics
Congenital heart disease
Pediatrics
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1432-1076
0340-6199
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headline:Clinical and haemodynamic correlates of heart rate variability in children with congenital heart disease
description: Heart rate variability (HRV) represents a noninvasive parameter for studying the autonomic control of the heart. Cardiac patients have a complex autonomic disturbance. The relation of HRV to this abnormality in children with congenital heart disease (CHD) has not yet been examined. The present study examined HRV indices from 24βh Holter recordings in 258 children with an operated or non-operated CHD, to determine their differences as an indicator of the severity of heart disease. The latter was defined clinically as New York Heart Association (NYHA) functional class I to IV and haemodynamically by invasive parameters. Five time-domain measures (SDNN, SDNNi, SDANNi, rMSSD and pNN50) and three frequency-domain measures (LF, HF and balance LF/HF) were compared with normal ranges. HRV was reduced in children with CHD, except in patients of NYHA class I. The level of reduction depended on the NYHA functional class. None of the measures was significantly related to haemodynamic data.
Conclusion Heart rate variability is reduced in children with Congenital heart disease depending on the functional limitation but not on haemodynamic disturbances. Heart rate variability indices are sensitive markers of the clinical state.
datePublished:
dateModified:
pageStart:967
pageEnd:971
sameAs:https://doi.org/10.1007/s004310050979
keywords:
Key words Heart rate variability
Childhood
Haemodynamics
Congenital heart disease
Pediatrics
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