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ebola, virus, article, disease, pubmed, children, google, scholar, guinea, study, health, evd, central, cohort, patients, chérif, clinical, sierra, leone, research, epidemic, manuscript, diallo, years, age, outbreak, pediatric, world, organization, med, privacy, cookies, content, data, journal, west, outcome, access, paediatric, accessed, authors, information, publish, search, pediatrics, nationwide, april, mahamoud, sama, koonrungsesomboon,

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int/csr/resources/publications/ebola/ebola-case-definition-contact-en int/ebola/current-situation/ebola-situation-report-30-march-2016 int/mediacentre/news/releases/2016/ebola-guinea/en/ int/mediacentre/news/releases/2016/ebola-liberia/en/ month download article/chapter int/iris/bitstream/10665/208883/1/ebolasitrep_10jun2016_eng ebola situation report case definition recommendations ebola virus disease edouard le gall ebola holding center national research committee mahamoud sama chérif article european journal threatened child health privacy choices/manage cookies inform treatment studies full article pdf case fatality rate ebola response team pediatrics aims marburg virus diseases nationwide cohort study ebola management centres european economic area related subjects kenji hirayama article chérif retrospective cohort study situation report sékou ditinn ciss� ongoing outbreak investigations fatoumata chérif ebola virus eleonor fundan avenido jui government hospital ethics declarations conflict significantly higher rate conditions privacy policy child health saliou bella diallo mamadou pathé diallo check access instant access pediatr infect dis 2014–2015 ebola outbreak accepting optional cookies laboratory-confirmed evd author information authors highest cfr

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         headline:Ebola virus disease in children during the 2014–2015 epidemic in Guinea: a nationwide cohort study
         description:The most recent epidemic of Ebola virus disease (EVD) has resulted in more than 11,000 deaths in West Africa. It has threatened child health in the affected countries, including Guinea. This nationwide retrospective cohort study included all children under 20 years of age with laboratory-confirmed EVD in Guinea during the 2014–2015 Ebola outbreak for analysis. Of 8,448 children with probable or suspected EVD, 695 cases were laboratory-confirmed EVD. The overall case fatality rate (CFR) was 62.9%. Pediatric patients with younger age had a significantly higher rate of death (adjusted OR = 0.995; 95%CI = 0.990–1.000; p = 0.046), with the highest CFR of 82.9% in children aged less than 5 years. Fever (91%), fatigue (87%), and gastrointestinal signs and symptoms (70%) were common clinical features on admission of the pediatric patients, while bleeding signs were not occurring often (24%). None of clinical features and epidemiologic risk factors for Ebola were associated with mortality outcome in our cohort study. Conclusion: EVD is a major threat to child health, especially among children under 5 years of age. To date, none of demographic and clinical features, except younger age, have been consistently shown to affect mortality outcome in children infected with Ebola virus.
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      headline:Ebola virus disease in children during the 2014–2015 epidemic in Guinea: a nationwide cohort study
      description:The most recent epidemic of Ebola virus disease (EVD) has resulted in more than 11,000 deaths in West Africa. It has threatened child health in the affected countries, including Guinea. This nationwide retrospective cohort study included all children under 20 years of age with laboratory-confirmed EVD in Guinea during the 2014–2015 Ebola outbreak for analysis. Of 8,448 children with probable or suspected EVD, 695 cases were laboratory-confirmed EVD. The overall case fatality rate (CFR) was 62.9%. Pediatric patients with younger age had a significantly higher rate of death (adjusted OR = 0.995; 95%CI = 0.990–1.000; p = 0.046), with the highest CFR of 82.9% in children aged less than 5 years. Fever (91%), fatigue (87%), and gastrointestinal signs and symptoms (70%) were common clinical features on admission of the pediatric patients, while bleeding signs were not occurring often (24%). None of clinical features and epidemiologic risk factors for Ebola were associated with mortality outcome in our cohort study. Conclusion: EVD is a major threat to child health, especially among children under 5 years of age. To date, none of demographic and clinical features, except younger age, have been consistently shown to affect mortality outcome in children infected with Ebola virus.
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            type:Organization
      name:Mandiou Diakité
      affiliation:
            name:Gamal Abdel Nasser University of Conakry
            address:
               name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
               type:PostalAddress
            type:Organization
      name:Mamadou Pathé Diallo
      affiliation:
            name:Gamal Abdel Nasser University of Conakry
            address:
               name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
               type:PostalAddress
            type:Organization
      name:Edouard Le Gall
      affiliation:
            name:Gamal Abdel Nasser University of Conakry
            address:
               name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
               type:PostalAddress
            type:Organization
            name:Pôle Régional de Cancérologie Bretagne
            address:
               name:Pôle Régional de Cancérologie Bretagne, Rennes, France
               type:PostalAddress
            type:Organization
      name:Mohamed Cissé
      affiliation:
            name:Gamal Abdel Nasser University of Conakry
            address:
               name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
               type:PostalAddress
            type:Organization
      name:Juntra Karbwang
      affiliation:
            name:Nagasaki University
            address:
               name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
               type:PostalAddress
            type:Organization
      name:Kenji Hirayama
      affiliation:
            name:Nagasaki University
            address:
               name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
      name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
      name:Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Ministry of Health and Public Hygiene, Conakry, Guinea
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Pôle Régional de Cancérologie Bretagne, Rennes, France
      name:Faculty of Medicine, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
      name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
      name:Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan
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