We are analyzing https://link.springer.com/article/10.1007/s004280050178.

Title:
Thymic myoid cell turnover in myasthenia gravis patients and in normal controls | Virchows Archiv
Description:
Thymic myoid cells (TMC) are sparse muscle-like cells in the thymic medulla, which are believed to trigger the autoimmune response in myasthenia gravis (MG). Ultrastructural investigations have revealed mature, degenerating, and immature TMC, but the number of TMC in MG patients does not differ from that in controls. We examined the turnover of TMC at the subcellular level, performing an immunocytochemical study with muscle-specific anti-desmin labelling of 10 thymuses derived from MG patients with lymphofollicular hyperplasia and from 8 normal controls. All thymuses examined revealed mature, immature, and degenerating TMC. Mature TMC contained desmin filaments in between Z-discs provided the sarcomeres were arranged in register. Morphological features of degenerating TMC included hypercontracted sarcomeres, cytoplasmic granular debris, chromatin clumping and, occasionally, membrane-bound bodies. Macrophages were not involved in the process. Immature TMC were of small diameter and contained myofilaments not arranged in myofibrils. In an MG thymus, small immature TMC were found clustered with dying TMC. It may be that degeneration of TMC is a stimulus for the generation of new TMC with faster turnover. This mechanism may mean that more antigen is available in MG patients than in normal controls, despite constant TMC numbers
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Keywords {🔍}

tmc, article, cells, access, privacy, cookies, content, myasthenia, gravis, patients, controls, thymus, information, publish, search, thymic, myoid, turnover, normal, immature, open, data, log, journal, research, virchows, archiv, cell, bornemann, kirchner, mature, degenerating, discover, springer, optional, personal, parties, policy, find, track, april, cite, antje, thomas, explore, revealed, examined, thymuses, contained, desmin,

Topics {✒️}

muscle-specific anti-desmin labelling month download article/chapter single-cell profiling myasthenia gravis identifies article bornemann full article pdf myasthenia gravis patients virchows archiv 432 privacy choices/manage cookies related subjects mg thymus check access instant access myasthenia gravis european economic area z-discs provided cytoplasmic granular debris membrane-bound bodies conditions privacy policy constant tmc numbers accepting optional cookies sparse muscle article log thymic medulla cells journal finder publish april 1998 volume 432 small immature tmc article cite revealed mature faster turnover kirchner privacy policy personal data contained myofilaments books a 8 normal controls normal controls optional cookies manage preferences 10 thymuses derived degenerating tmc subscription content similar content data protection essential cookies cookies skip turnover small diameter institution subscribe

Schema {🗺️}

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         headline:Thymic myoid cell turnover in myasthenia gravis patients and in normal controls
         description: Thymic myoid cells (TMC) are sparse muscle-like cells in the thymic medulla, which are believed to trigger the autoimmune response in myasthenia gravis (MG). Ultrastructural investigations have revealed mature, degenerating, and immature TMC, but the number of TMC in MG patients does not differ from that in controls. We examined the turnover of TMC at the subcellular level, performing an immunocytochemical study with muscle-specific anti-desmin labelling of 10 thymuses derived from MG patients with lymphofollicular hyperplasia and from 8 normal controls. All thymuses examined revealed mature, immature, and degenerating TMC. Mature TMC contained desmin filaments in between Z-discs provided the sarcomeres were arranged in register. Morphological features of degenerating TMC included hypercontracted sarcomeres, cytoplasmic granular debris, chromatin clumping and, occasionally, membrane-bound bodies. Macrophages were not involved in the process. Immature TMC were of small diameter and contained myofilaments not arranged in myofibrils. In an MG thymus, small immature TMC were found clustered with dying TMC. It may be that degeneration of TMC is a stimulus for the generation of new TMC with faster turnover. This mechanism may mean that more antigen is available in MG patients than in normal controls, despite constant TMC numbers
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         dateModified:
         pageStart:357
         pageEnd:361
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            Myoid cells
            Desmin
            Myasthenia gravis
            Immunoelectron microscopy
            Pathology
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      headline:Thymic myoid cell turnover in myasthenia gravis patients and in normal controls
      description: Thymic myoid cells (TMC) are sparse muscle-like cells in the thymic medulla, which are believed to trigger the autoimmune response in myasthenia gravis (MG). Ultrastructural investigations have revealed mature, degenerating, and immature TMC, but the number of TMC in MG patients does not differ from that in controls. We examined the turnover of TMC at the subcellular level, performing an immunocytochemical study with muscle-specific anti-desmin labelling of 10 thymuses derived from MG patients with lymphofollicular hyperplasia and from 8 normal controls. All thymuses examined revealed mature, immature, and degenerating TMC. Mature TMC contained desmin filaments in between Z-discs provided the sarcomeres were arranged in register. Morphological features of degenerating TMC included hypercontracted sarcomeres, cytoplasmic granular debris, chromatin clumping and, occasionally, membrane-bound bodies. Macrophages were not involved in the process. Immature TMC were of small diameter and contained myofilaments not arranged in myofibrils. In an MG thymus, small immature TMC were found clustered with dying TMC. It may be that degeneration of TMC is a stimulus for the generation of new TMC with faster turnover. This mechanism may mean that more antigen is available in MG patients than in normal controls, despite constant TMC numbers
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      pageEnd:361
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         Immunoelectron microscopy
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