We are analyzing https://link.springer.com/article/10.1007/s004280050142.

Title:
Molecular characterization of intraductal breast carcinomas | Virchows Archiv
Description:
In situ duct carcinoma (DCIS) is a heterogeneous group of lesions which has recently been subdivided into three types: well-differentiated (type I), intermediately differentiated (type II) and poorly differentiated (type III) DCIS. Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of β-actin, EGFR, c-cerbB2, MTS1, k-ras, RB, BRCA1, cyclin E, and c-myc genes. A microdissection technique was used on paraffin-embedded tissue. A statistically significantly higher expression of cyclin E oncogene and MTS1 tumor suppressor gene was seen in type III DCIS than in the other types, while no significant differences in the mRNA expression patterns of the other genes were observed. These data are consistent with the fact that poorly differentiated DCIS is a readily recognizable class of tumours that have a particularly aggressive behaviour and probably unique histogenesis.
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Keywords {🔍}

article, carcinoma, breast, dcis, access, privacy, cookies, content, data, information, publish, search, molecular, type, ductal, log, journal, research, virchows, archiv, intraductal, stanta, bonin, losi, situ, differentiated, cyclin, open, cancer, discover, springer, optional, personal, parties, policy, find, track, characterization, carcinomas, cite, giorgio, serena, luisa, eusebi, explore, duct, types, poorly, iii, mrna,

Topics {✒️}

invasive breast cancer situ duct carcinoma intraductal breast carcinomas month download article/chapter c-myc access related subjects privacy choices/manage cookies full article pdf ductal carcinoma virchows archiv 432 c-myc genes european economic area paraffin-embedded tissue mrna expression patterns readily recognizable class micro-environmental diversity molecular characterization article stanta conditions privacy policy accepting optional cookies journal finder publish check access instant access article log c-cerbb2 article cite type iii dcis poorly differentiated dcis serena bonin privacy policy molecular features books a information personal data optional cookies manage preferences subscription content similar content essential cookies cookies skip poorly differentiated type iii mrna levels institution subscribe journal publish cyclin data protection usage analysis social media varying standards

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         headline:Molecular characterization of intraductal breast carcinomas
         description: In situ duct carcinoma (DCIS) is a heterogeneous group of lesions which has recently been subdivided into three types: well-differentiated (type I), intermediately differentiated (type II) and poorly differentiated (type III) DCIS. Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of β-actin, EGFR, c-cerbB2, MTS1, k-ras, RB, BRCA1, cyclin E, and c-myc genes. A microdissection technique was used on paraffin-embedded tissue. A statistically significantly higher expression of cyclin E oncogene and MTS1 tumor suppressor gene was seen in type III DCIS than in the other types, while no significant differences in the mRNA expression patterns of the other genes were observed. These data are consistent with the fact that poorly differentiated DCIS is a readily recognizable class of tumours that have a particularly aggressive behaviour and probably unique histogenesis.
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      headline:Molecular characterization of intraductal breast carcinomas
      description: In situ duct carcinoma (DCIS) is a heterogeneous group of lesions which has recently been subdivided into three types: well-differentiated (type I), intermediately differentiated (type II) and poorly differentiated (type III) DCIS. Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of β-actin, EGFR, c-cerbB2, MTS1, k-ras, RB, BRCA1, cyclin E, and c-myc genes. A microdissection technique was used on paraffin-embedded tissue. A statistically significantly higher expression of cyclin E oncogene and MTS1 tumor suppressor gene was seen in type III DCIS than in the other types, while no significant differences in the mRNA expression patterns of the other genes were observed. These data are consistent with the fact that poorly differentiated DCIS is a readily recognizable class of tumours that have a particularly aggressive behaviour and probably unique histogenesis.
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