We are analyzing https://link.springer.com/article/10.1007/s004280050053.

Title:
The multiple roles of tumour stroma | Virchows Archiv
Description:
Since the work of Judah Folkman in the 1970s demonstrating the importance of vascularization on tumour growth the many roles played by tumour stroma have been demonstrated. Vascular endothelial growth factor/vascular permeability factor appears to be the main in vivo inducer of both stromal blood vessels and other components of the tumour stroma. Its action is probably mediated through its strong and long-lasting effect on microvascular permeability leading to fibrin extravasation and organisation (”tumours are wounds that do not heal”). During tumour invasion, stromal fibroblasts participate in the degradation of the extracellular matrix (ECM) by secreting matrix degrading proteases as well as their downstream-activators. Stroma derived factors such as scatter factor/hepatocyte growth factor as well as interactions between neoplastic cells and the ECM can play a role in both tumour cell migration and proliferation. The ECM may also act as a reservoir for growth factors. A novel transcription factor encoded by the c-ets 1 proto-oncogene is likely to be involved in the transcriptional regulation of both tumour vascularization and invasion. This contribution summarizes recent developments in the tumour stroma field.
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Keywords {🔍}

tumour, article, stroma, privacy, cookies, content, matrix, access, information, publish, search, roles, growth, factor, extracellular, data, log, journal, research, virchows, archiv, wernert, ecm, role, support, chapter, discover, springer, optional, personal, parties, policy, main, find, track, multiple, cite, explore, vascularization, permeability, stromal, invasion, factors, institution, cancer, open, tumor, barrier, related, subjects,

Topics {✒️}

c-ets 1 proto-oncogene month download article/chapter transcription factor encoded microvascular permeability leading privacy choices/manage cookies tumour stroma field tumour cell migration extracellular matrix full article pdf tumour growth european economic area scope submit manuscript stromal blood vessels long-lasting effect stromal fibroblasts participate conditions privacy policy virchows archiv 430 stroma derived factors tumour stroma accepting optional cookies journal finder publish article wernert check access related subjects instant access growth factors tumour invasion tumour vascularization article log privacy policy personal data information books a article cite multiple roles roles played tumor stroma optional cookies manage preferences subscription content similar content data protection essential cookies cookies skip institution subscribe journal publish usage analysis social media varying standards june 1997 volume 430

Questions {❓}

Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?

Schema {🗺️}

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