LINK . SPRINGER . COM {
}
Title:
Pax-6 origins – implications from the structure of two coral Pax genes | Discover Developmental Biology
Description:
Vertebrate Pax-6 and its Drosophila homolog eyeless play central roles in eye specification, although it is not clear if this represents the ancestral role of this gene class. As the most ”primitive” animals with true nervous systems, the Cnidaria may be informative in terms of the evolution of the Pax gene family. For this reason we surveyed the Pax gene complement of a representative of the basal cnidarian class (the Anthozoa), the coral Acropora millepora. cDNAs encoding two coral Pax proteins were isolated. Pax-Aam encoded a protein containing only a paired domain, whereas Pax-Cam also contained a homeodomain clearly related to those in the Pax-6 family. The paired domains in both proteins most resembled the vertebrate Pax-2/5/8 class, but shared several distinctive substitutions. As in most Pax-6 homologs and orthologs, an intron was present in the Pax-Cam locus at a position corresponding to residues 46/47 in the homeodomain. We propose a model for evolution of the Pax family, in which the ancestor of all of the vertebrate Pax genes most resembled Pax-6, and arose via fusion of a Pax-Aam-like gene (encoding only a paired domain) with an anteriorly-expressed homeobox gene resembling the paired -like class.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Science
- Animals & Wildlife
- Social Networks
Content Management System {📝}
What CMS is link.springer.com built with?
Custom-built
No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of link.springer.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Link.springer.com Make Money? {💸}
We can't see how the site brings in money.
While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.
Keywords {🔍}
pax, genes, article, gene, evolution, privacy, cookies, coral, family, paired, content, information, publish, research, search, class, data, journal, download, catmull, hayward, mcintyre, vertebrate, related, discover, university, optional, analysis, personal, parties, policy, find, track, development, origins, implications, structure, cite, pdf, manuscript, naomi, john, reecehoyes, rebecca, mastro, callaerts, eldon, ball, miller, explore,
Topics {✒️}
coral pax genes vertebrate pax genes coral acropora millepora pax family genes privacy choices/manage cookies molecular biology coral pax proteins pax gene complement main content log pax gene family european economic area true nervous systems vertebrate pax-2/5/8 class pax-aam encoded pax-cam locus conditions privacy policy related subjects evolution aims james cook university australian national university basal cnidarian class accepting optional cookies scope submit manuscript journal finder publish pax6 mutations search search evolution article cite article catmull eye specification pax-6 family pax family pax-cam pax-aam gene class privacy policy personal data books a pax-6 homologs information paired domain paired domains optional cookies manage preferences resembled pax-6 data protection essential cookies cookies skip journal publish social media
Schema {🗺️}
WebPage:
mainEntity:
headline:Pax-6 origins – implications from the structure of two coral Pax genes
description: Vertebrate Pax-6 and its Drosophila homolog eyeless play central roles in eye specification, although it is not clear if this represents the ancestral role of this gene class. As the most ”primitive” animals with true nervous systems, the Cnidaria may be informative in terms of the evolution of the Pax gene family. For this reason we surveyed the Pax gene complement of a representative of the basal cnidarian class (the Anthozoa), the coral Acropora millepora. cDNAs encoding two coral Pax proteins were isolated. Pax-Aam encoded a protein containing only a paired domain, whereas Pax-Cam also contained a homeodomain clearly related to those in the Pax-6 family. The paired domains in both proteins most resembled the vertebrate Pax-2/5/8 class, but shared several distinctive substitutions. As in most Pax-6 homologs and orthologs, an intron was present in the Pax-Cam locus at a position corresponding to residues 46/47 in the homeodomain. We propose a model for evolution of the Pax family, in which the ancestor of all of the vertebrate Pax genes most resembled Pax-6, and arose via fusion of a Pax-Aam-like gene (encoding only a paired domain) with an anteriorly-expressed homeobox gene resembling the paired
-like class.
datePublished:
dateModified:
pageStart:352
pageEnd:356
sameAs:https://doi.org/10.1007/s004270050191
keywords:
Key words Pax-6
Coral
Acropora
Homeobox
Paired box
Developmental Biology
Evolutionary Biology
Zoology
Animal Genetics and Genomics
Cell Biology
image:
isPartOf:
name:Development Genes and Evolution
issn:
1432-041X
0949-944X
volumeNumber:208
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:J. Catmull
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:D. C. Hayward
affiliation:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:Naomi E. McIntyre
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:John S. Reece-Hoyes
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:Rebecca Mastro
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:P. Callaerts
affiliation:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
address:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland, , CH
type:PostalAddress
type:Organization
type:Person
name:Eldon E. Ball
affiliation:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:D. J. Miller
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Pax-6 origins – implications from the structure of two coral Pax genes
description: Vertebrate Pax-6 and its Drosophila homolog eyeless play central roles in eye specification, although it is not clear if this represents the ancestral role of this gene class. As the most ”primitive” animals with true nervous systems, the Cnidaria may be informative in terms of the evolution of the Pax gene family. For this reason we surveyed the Pax gene complement of a representative of the basal cnidarian class (the Anthozoa), the coral Acropora millepora. cDNAs encoding two coral Pax proteins were isolated. Pax-Aam encoded a protein containing only a paired domain, whereas Pax-Cam also contained a homeodomain clearly related to those in the Pax-6 family. The paired domains in both proteins most resembled the vertebrate Pax-2/5/8 class, but shared several distinctive substitutions. As in most Pax-6 homologs and orthologs, an intron was present in the Pax-Cam locus at a position corresponding to residues 46/47 in the homeodomain. We propose a model for evolution of the Pax family, in which the ancestor of all of the vertebrate Pax genes most resembled Pax-6, and arose via fusion of a Pax-Aam-like gene (encoding only a paired domain) with an anteriorly-expressed homeobox gene resembling the paired
-like class.
datePublished:
dateModified:
pageStart:352
pageEnd:356
sameAs:https://doi.org/10.1007/s004270050191
keywords:
Key words Pax-6
Coral
Acropora
Homeobox
Paired box
Developmental Biology
Evolutionary Biology
Zoology
Animal Genetics and Genomics
Cell Biology
image:
isPartOf:
name:Development Genes and Evolution
issn:
1432-041X
0949-944X
volumeNumber:208
type:
Periodical
PublicationVolume
publisher:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:J. Catmull
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:D. C. Hayward
affiliation:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:Naomi E. McIntyre
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:John S. Reece-Hoyes
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:Rebecca Mastro
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:P. Callaerts
affiliation:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
address:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland, , CH
type:PostalAddress
type:Organization
type:Person
name:Eldon E. Ball
affiliation:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
type:Organization
type:Person
name:D. J. Miller
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Development Genes and Evolution
issn:
1432-041X
0949-944X
volumeNumber:208
Organization:
name:Springer-Verlag
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
address:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland, , CH
type:PostalAddress
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:J. Catmull
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
name:D. C. Hayward
affiliation:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
type:Organization
name:Naomi E. McIntyre
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
name:John S. Reece-Hoyes
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
name:Rebecca Mastro
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
name:P. Callaerts
affiliation:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
address:
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland, , CH
type:PostalAddress
type:Organization
name:Eldon E. Ball
affiliation:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
address:
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
type:PostalAddress
type:Organization
name:D. J. Miller
affiliation:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia
address:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
type:PostalAddress
type:Organization
PostalAddress:
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
name:Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland, , CH
name:Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia, , AU
name:Department of Biochemistry and Molecular Biology, James Cook University, Townsville, Queensland 4811, Australia, , AU
External Links {🔗}(39)
- What's the income generated by https://www.springernature.com/gp/authors each month?
- How much does https://link.springernature.com/home/ pull in monthly?
- What is the monthly revenue of https://order.springer.com/public/cart?
- https://submission.nature.com/new-submission/427/3's total income per month
- How much does https://beta.springernature.com/pre-submission?journalId=427 net monthly?
- What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J.%20Catmull?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J.%20Catmull%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
- What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D.%20C.%20Hayward?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D.%20C.%20Hayward%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Naomi%20E.%20McIntyre make?
- How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Naomi%20E.%20McIntyre%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=John%20S.%20Reece-Hoyes?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22John%20S.%20Reece-Hoyes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rebecca%20Mastro is on a monthly basis
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rebecca%20Mastro%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=P.%20Callaerts make?
- Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22P.%20Callaerts%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Eldon%20E.%20Ball?
- Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Eldon%20E.%20Ball%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D.%20J.%20Miller generate?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D.%20J.%20Miller%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- Earnings of https://s100.copyright.com/AppDispatchServlet?title=Pax-6%20origins%20%E2%80%93%20implications%20from%20the%20structure%20of%20two%20coral%20Pax%20genes&author=J.%20Catmull%20et%20al&contentID=10.1007%2Fs004270050191©right=Springer-Verlag%20Berlin%20Heidelberg&publication=0949-944X&publicationDate=1998-08&publisherName=SpringerNature&orderBeanReset=true
- What's https://citation-needed.springer.com/v2/references/10.1007/s004270050191?format=refman&flavour=citation's gross income?
- How much does https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral pull in monthly?
- How much cash flow does https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research have monthly?
- Explore the financials of https://www.springernature.com/gp/products
- https://www.springernature.com/gp/librarians's total income per month
- What's the total monthly financial gain of https://www.springernature.com/gp/societies?
- How much revenue does https://www.springernature.com/gp/partners bring in?
- What's the total monthly financial gain of https://www.springer.com/?
- What is the earnings of https://www.nature.com/?
- How much money does https://www.biomedcentral.com/ make?
- What's the monthly money flow for https://www.palgrave.com/?
- Revenue of https://www.apress.com/
- Financial intake of https://www.springernature.com/gp/legal/ccpa
- Financial intake of https://www.springernature.com/gp/info/accessibility
- How much does https://support.springernature.com/en/support/home rake in every month?
- Get to know https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations's earnings
- How much does https://www.springernature.com/ rake in every month?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref