We are analyzing https://link.springer.com/article/10.1007/s004270000106.

Title:
Origin of the paired domain | Discover Developmental Biology
Description:
Pax proteins play a diverse role in early animal development and contain the characteristic paired domain, consisting of two conserved helix-turn-helix motifs. In many Pax proteins the paired domain is fused to a second DNA binding domain of the paired-like homeobox family. By amino acid sequence alignments, secondary structure prediction, 3D-structure comparison, and phylogenetic reconstruction, we analyzed the relationship between Pax proteins and members of the Tc1 family of transposases, which possibly share a common ancestor with Pax proteins. We suggest that the DNA binding domain of an ancestral transposase (proto-Pax transposase) was fused to a homeodomain shortly after the emergence of metazoans about one billion years ago. Using the transposase sequences as an outgroup we reexamined the early evolution of the Pax proteins. Our novel evolutionary scenario features a single homeobox capturing event and an early duplication of Pax genes before the divergence of porifera, indicating a more diverse role of Pax proteins in primitive animals than previously expected.
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Keywords {🔍}

pax, article, proteins, domain, evolution, privacy, cookies, paired, content, information, publish, research, search, transposase, data, journal, development, genes, download, breitling, gerber, role, early, dna, homeobox, family, gene, human, discover, optional, analysis, personal, parties, policy, find, track, origin, sequence, cite, pdf, manuscript, rainer, explore, diverse, characteristic, fused, binding, common, september, related,

Topics {✒️}

conserved helix-turn-helix motifs dna binding domain characteristic paired domain privacy choices/manage cookies early evolution related subjects evolution aims proto-pax transposase early animal development pax gene family pax proteins main content log european economic area secondary structure prediction 3d-structure comparison billion years ago evolutionary scenario features germany e-mail conditions privacy policy article breitling accepting optional cookies pax genes paired domain homeobox family journal finder publish search search pax6 mutations article cite information common ancestor ancestral transposase transposase sequences privacy policy personal data books a optional cookies manage preferences data protection essential cookies cookies skip de tel journal publish tc1 family early duplication social media varying standards november 2000 volume 210 diverse role phylogenetic reconstruction possibly share

Schema {🗺️}

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         headline:Origin of the paired domain
         description:Pax proteins play a diverse role in early animal development and contain the characteristic paired domain, consisting of two conserved helix-turn-helix motifs. In many Pax proteins the paired domain is fused to a second DNA binding domain of the paired-like homeobox family. By amino acid sequence alignments, secondary structure prediction, 3D-structure comparison, and phylogenetic reconstruction, we analyzed the relationship between Pax proteins and members of the Tc1 family of transposases, which possibly share a common ancestor with Pax proteins. We suggest that the DNA binding domain of an ancestral transposase (proto-Pax transposase) was fused to a homeodomain shortly after the emergence of metazoans about one billion years ago. Using the transposase sequences as an outgroup we reexamined the early evolution of the Pax proteins. Our novel evolutionary scenario features a single homeobox capturing event and an early duplication of Pax genes before the divergence of porifera, indicating a more diverse role of Pax proteins in primitive animals than previously expected.
         datePublished:
         dateModified:
         pageStart:644
         pageEnd:650
         sameAs:https://doi.org/10.1007/s004270000106
         keywords:
            Keywords Pax protein
            Paired domain
            Homeobox
            Transposase
            Evolution
            Developmental Biology
            Evolutionary Biology
            Zoology
            Animal Genetics and Genomics
            Cell Biology
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         author:
               name:Rainer Breitling
               affiliation:
                     name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225
                     address:
                        name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
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                     address:
                        name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
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ScholarlyArticle:
      headline:Origin of the paired domain
      description:Pax proteins play a diverse role in early animal development and contain the characteristic paired domain, consisting of two conserved helix-turn-helix motifs. In many Pax proteins the paired domain is fused to a second DNA binding domain of the paired-like homeobox family. By amino acid sequence alignments, secondary structure prediction, 3D-structure comparison, and phylogenetic reconstruction, we analyzed the relationship between Pax proteins and members of the Tc1 family of transposases, which possibly share a common ancestor with Pax proteins. We suggest that the DNA binding domain of an ancestral transposase (proto-Pax transposase) was fused to a homeodomain shortly after the emergence of metazoans about one billion years ago. Using the transposase sequences as an outgroup we reexamined the early evolution of the Pax proteins. Our novel evolutionary scenario features a single homeobox capturing event and an early duplication of Pax genes before the divergence of porifera, indicating a more diverse role of Pax proteins in primitive animals than previously expected.
      datePublished:
      dateModified:
      pageStart:644
      pageEnd:650
      sameAs:https://doi.org/10.1007/s004270000106
      keywords:
         Keywords Pax protein
         Paired domain
         Homeobox
         Transposase
         Evolution
         Developmental Biology
         Evolutionary Biology
         Zoology
         Animal Genetics and Genomics
         Cell Biology
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                  address:
                     name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
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                  name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225
                  address:
                     name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
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      name:Development Genes and Evolution
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         name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
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Person:
      name:Rainer Breitling
      affiliation:
            name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225
            address:
               name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
               type:PostalAddress
            type:Organization
      name:J.-K. Gerber
      affiliation:
            name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225
            address:
               name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
               type:PostalAddress
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      name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE
      name:GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, 85764 Neuherberg, Germany e-mail: [email protected] Tel.: +49-89-31873229, Fax: +49-89-31873225, , DE

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