We are analyzing https://link.springer.com/article/10.1007/s00427-004-0402-8.

Title:
Organization of Iroquois genes in fish | Discover Developmental Biology
Description:
In mammals, a total of six iroquois (Irx) genes exist, which are organized into two clusters. Here we report on the organization of all iroquois genes present in fish, using zebrafish (Danio rerio) and pufferfish (Fugu rubripes and Tetraodon nigroviridis) as examples. A total of 10 Irx genes were found in pufferfish, and 11 in zebrafish; all but one of these genes are organized into clusters (four clusters plus one isolated gene locus). The “extra” fish clusters result from chromosome duplication in the fish lineage, after its divergence from tetrapod vertebrates. Two of the four fish clusters are highly conserved to the ones in mammals, with regard to similarity of genes and cluster architecture. Irx genes within the other two clusters have diverged in sequence and cluster organization, suggesting functional divergence. These results will allow us to use the zebrafish system for functional and comparative studies of iroquois genes in vertebrate development.
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Keywords {🔍}

genes, gene, irx, clusters, zebrafish, cluster, irxb, fugu, irxa, fish, mammalian, flanking, organization, sequences, iroquois, google, scholar, contigs, genome, diversification, fig, sequence, data, article, pubmed, duplication, species, present, vertebrate, cas, panel, development, duplicated, mapping, coding, loci, evolution, lineage, duplicate, mammals, presence, linkage, chromosomal, nigroviridis, conserved, shown, additional, est, set, genomic,

Topics {✒️}

duplicate pair trf4-1a/trf4-1b related clusters irx3a-irx5a-irx6a de la calle-mustienes related clusters irx1a-irx2a-irx4a phylip—phylogeny inference package dorsal/ventral pattern define bac/pac clone ends pac/bac clone ends c-terminal iro-box mammalian irx3-irx5-irx6 cluster n-terminal region including c-terminal region homology ora gene repertoire gene-cluster architecture discussed gómez-skarmeta jl related subjects clusters irx3a-irx5a-irx6a privacy choices/manage cookies full size image bac/pac clones electronic supplementary material trf4-1a duplicate present larger chromosomal region irx1a-irx2a-irx4a cluster large insert clones fugu genes rbl2-irx5b-ftm n-terminal region duplicates adcy2a/adcy2b relative insert dna clones human/murine irx genes clusters irx1a-irx2a-irx4a larger scaffolds found van de peer article dildrop unique insertions/deletions ancestral cluster duplication iroquois protein family inferred ancestral codon bac clone ends amino acid differences ancestral duplication event amino acid sequences irx genes separated iroquois3 homeobox gene subtype-specific properties large intergenic regions additional species belonging mammalian protein sequences long separation time fugu loci carrying

Questions {❓}

Heasman J (2002) Morpholino oligos: making sense of antisense?

Schema {🗺️}

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         description:In mammals, a total of six iroquois (Irx) genes exist, which are organized into two clusters. Here we report on the organization of all iroquois genes present in fish, using zebrafish (Danio rerio) and pufferfish (Fugu rubripes and Tetraodon nigroviridis) as examples. A total of 10 Irx genes were found in pufferfish, and 11 in zebrafish; all but one of these genes are organized into clusters (four clusters plus one isolated gene locus). The “extra” fish clusters result from chromosome duplication in the fish lineage, after its divergence from tetrapod vertebrates. Two of the four fish clusters are highly conserved to the ones in mammals, with regard to similarity of genes and cluster architecture. Irx genes within the other two clusters have diverged in sequence and cluster organization, suggesting functional divergence. These results will allow us to use the zebrafish system for functional and comparative studies of iroquois genes in vertebrate development.
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      headline:Organization of Iroquois genes in fish
      description:In mammals, a total of six iroquois (Irx) genes exist, which are organized into two clusters. Here we report on the organization of all iroquois genes present in fish, using zebrafish (Danio rerio) and pufferfish (Fugu rubripes and Tetraodon nigroviridis) as examples. A total of 10 Irx genes were found in pufferfish, and 11 in zebrafish; all but one of these genes are organized into clusters (four clusters plus one isolated gene locus). The “extra” fish clusters result from chromosome duplication in the fish lineage, after its divergence from tetrapod vertebrates. Two of the four fish clusters are highly conserved to the ones in mammals, with regard to similarity of genes and cluster architecture. Irx genes within the other two clusters have diverged in sequence and cluster organization, suggesting functional divergence. These results will allow us to use the zebrafish system for functional and comparative studies of iroquois genes in vertebrate development.
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         Evolutionary Biology
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         Cell Biology
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