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month download article/chapter single-channel slope conductance rat intracardiac neurons patch-clamp recording technique cell-attached recording configuration single ca2+-activated related subjects full article pdf open channel action potential duration privacy choices/manage cookies channel activity increased action potential check access instant access channels european economic area scope submit manuscript voltage range –60/+60 mv hill plot giving external tetraethylammonium conditions privacy policy half-saturating [ca2+] accepting optional cookies article log apamin universita' di perugia main content log article cite article franciolini journal finder publish bk channel na+ ions afterhyperpolarization privacy policy books a personal data resting activity optional cookies manage preferences ions charybdotoxin essential cookies cookies skip subscription content similar content information institution subscribe journal publish data protection

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         headline:Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons
         description: The properties of single Ca2+-activated K+ (BK) channels in neonatal rat intracardiac neurons were investigated using the patch-clamp recording technique. In symmetrical 140 mM K+, the single-channel slope conductance was linear in the voltage range –60/+60 mV, and was 207±19 pS. Na+ ions were not measurably permeant through the open channel. Channel activity increased with the cytoplasmic free Ca2+ concentration ([Ca2+]i) with a Hill plot giving a half-saturating [Ca2+] (K 0.5) of 1.35 µM and slope of ≅3. The BK channel was inhibited reversibly by external tetraethylammonium (TEA) ions, charybdotoxin, and quinine and was resistant to block by 4-aminopyridine and apamin. Ionomycin (1–10 µM) increased BK channel activity in the cell-attached recording configuration. The resting activity was consistent with a [Ca2+]i <100 nM and the increased channel activity evoked by ionomycin was consistent with a rise in [Ca2+]i to ≥0.3 µM. TEA (0.2–1 mM) increased the action potential duration ≅1.5-fold and reduced the amplitude and duration of the afterhyperpolarization (AHP) by 26%. Charybdotoxin (100 nM) did not significantly alter the action potential duration or AHP amplitude but reduced the AHP duration by ≅40%. Taken together, these data indicate that BK channel activation contributes to the action potential and AHP duration in rat intracardiac neurons.
         datePublished:2000-11-28T00:00:00Z
         dateModified:2000-11-28T00:00:00Z
         pageStart:629
         pageEnd:638
         sameAs:https://doi.org/10.1007/s004240000471
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            Action potential Afterhyperpolarization Charybdotoxin Intracellular calcium Parasympathetic neurons Tetraethylammonium ions
            Human Physiology
            Molecular Medicine
            Neurosciences
            Cell Biology
            Receptors
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      headline:Large-conductance calcium-activated potassium channels in neonatal rat intracardiac ganglion neurons
      description: The properties of single Ca2+-activated K+ (BK) channels in neonatal rat intracardiac neurons were investigated using the patch-clamp recording technique. In symmetrical 140 mM K+, the single-channel slope conductance was linear in the voltage range –60/+60 mV, and was 207±19 pS. Na+ ions were not measurably permeant through the open channel. Channel activity increased with the cytoplasmic free Ca2+ concentration ([Ca2+]i) with a Hill plot giving a half-saturating [Ca2+] (K 0.5) of 1.35 µM and slope of ≅3. The BK channel was inhibited reversibly by external tetraethylammonium (TEA) ions, charybdotoxin, and quinine and was resistant to block by 4-aminopyridine and apamin. Ionomycin (1–10 µM) increased BK channel activity in the cell-attached recording configuration. The resting activity was consistent with a [Ca2+]i <100 nM and the increased channel activity evoked by ionomycin was consistent with a rise in [Ca2+]i to ≥0.3 µM. TEA (0.2–1 mM) increased the action potential duration ≅1.5-fold and reduced the amplitude and duration of the afterhyperpolarization (AHP) by 26%. Charybdotoxin (100 nM) did not significantly alter the action potential duration or AHP amplitude but reduced the AHP duration by ≅40%. Taken together, these data indicate that BK channel activation contributes to the action potential and AHP duration in rat intracardiac neurons.
      datePublished:2000-11-28T00:00:00Z
      dateModified:2000-11-28T00:00:00Z
      pageStart:629
      pageEnd:638
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         Action potential Afterhyperpolarization Charybdotoxin Intracellular calcium Parasympathetic neurons Tetraethylammonium ions
         Human Physiology
         Molecular Medicine
         Neurosciences
         Cell Biology
         Receptors
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