We are analyzing https://link.springer.com/article/10.1007/s00424-010-0847-8.

Title:
Canonical TRP channels and mechanotransduction: from physiology to disease states | Pflügers Archiv - European Journal of Physiology
Description:
Mechano-gated ion channels play a key physiological role in cardiac, arterial, and skeletal myocytes. For instance, opening of the non-selective stretch-activated cation channels in smooth muscle cells is involved in the pressure-dependent myogenic constriction of resistance arteries. These channels are also implicated in major pathologies, including cardiac hypertrophy or Duchenne muscular dystrophy. Seminal work in prokaryotes and invertebrates highlighted the role of transient receptor potential (TRP) channels in mechanosensory transduction. In mammals, recent findings have shown that the canonical TRPC1 and TRPC6 channels are key players in muscle mechanotransduction. In the present review, we will focus on the functional properties of TRPC1 and TRPC6 channels, on their mechano-gating, regulation by interacting cytoskeletal and scaffolding proteins, physiological role and implication in associated diseases.
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Keywords {🔍}

google, scholar, article, pubmed, cas, channels, trpc, cell, channel, receptor, muscle, nature, biol, mechanosensitive, physiol, cardiac, mol, trp, transient, potential, rev, ion, cation, sachs, mechanotransduction, cells, myogenic, sci, nat, patel, calcium, signaling, honoré, role, stretchactivated, angiotensin, protein, vascular, activation, usa, circ, heart, mori, canonical, disease, folgering, bichet, smooth, hypertrophy, regulation,

Topics {✒️}

phospholipase a2/{omega}-hydroxylase/20-hete pathways 1-oleoyl-2-acetyl-sn-glycerol mhc store-operated cation influx large-conductance mechanosensitive channel stretch-activated cation channel transient receptor potential month download article/chapter stretch-inactivated ion channels anr 2005 cardiovasculaire-obésité-diabète stretch-activated channel blockers cardiac mechano-gated fabrice duprat & eric honor� stretch-induced muscle damage pressure-dependent myogenic constriction cardiac mechano-electric feedback mechanosensitive cation channels receptor-operated channel mechanosensitive ion channels store-operated channel trpc6 cation channel stretch-sensitive channels regulate calcium signaling mechano-electric feedback related subjects full article pdf signaling mechanisms underlying ion channel polycystin-2 stretch-activated channels canonical trp channels nice sophia antipolis reza sharif-naeini angiotensin ii smooth muscle cells vascular myogenic response european economic area privacy choices/manage cookies vascular trpc6 channel capacitative calcium entries nitric oxide production polycystic kidney disease isolated rat kidney protein kinase cascades nauli sm fondation de france muscle cell surface walker rg including cardiac hypertrophy rat interlobular artery calcineurin signaling circuit ion channels

Questions {❓}

Christensen AP, Corey DP (2007) TRP channels in mechanosensation: direct or indirect activation?

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